BIKE_Hsap MKKFSRMPKSE---GGSGGGAAGGG---AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLE
AAK1_Hsap MKKFFDSRREQ---GGSGLGS--GS---SGGGG--STSGLGSGYIG-RVFGIGRQQVTVD
BIKE_Mmus MKKFSRMPKSE---GSGGG-AAAGG---AAGGG--LGGGFASSSMGVRVFAVGRYQVTLE
AAK1_Mmus MKKFFDSRREQ---GSSGLGS--GS---SGGGG--SSSGLGSGYIG-RVFGIGRQQVTVD
sel-5_Cele MPLGLFSSGKA--QVLCD-EKIP-----GGKKK-EPKQLSENKCKG-VTLKLDHTRVTIE
DDB0229347_Ddis MNRFLEFSNNFLEVAGNTINNISSKSITDNVGN--VWGNITGGRVG-QVYDINGRRVTEV
DDB0229350_Ddis MG----------------------------------------NNQG-KTLKIGSYHLNFV
Nak_Dmel MKKILSKFERN---ENSRLEN--PP---NSSSS--SSSNEKNSFVG-KVFTVGRVTVTVE
AKL1_Scer MSITNGTSRSV---SAM------------------GHPAVERYTPG-HIVCVGTHKVEVV
ARK1_Scer MNQP----------------------------------QIGTYNVG-TQLTVGSHQVEII
PRK1_Scer MNTP----------------------------------QISLYEPG-TILTVGSHHAKII
AAK1_Spur MV----------------------------------------------------------
AqueK170_Aque MAELVRKRS-S---G---------------------RQRLRQGYVG-KTFTLDGRQYIVE
*
BIKE_Hsap ESLAEGGFSTVFLVRTH---------------GGIRCALKRMYVN-NMPDLNVCKREITI
AAK1_Hsap EVLAEGGFAIVFLVRTS---------------NGMKCALKRMFVN-NEHDLQVCKREIQI
BIKE_Mmus ESLAEGGFSTVFLVRTH---------------SGIRCALKRMYVN-NTPDLNICKREITI
AAK1_Mmus EVLAEGGFALVFLVRTS---------------NGVKCALKRMFVN-NEHDLQVCKREIQI
sel-5_Cele KQIAEGGFAIVYVASDRK---------------NNKFALKRQFTKDNEKQLEACCREHSF
DDB0229347_Ddis KLVAEGGFGFVYLVRDDY--------------N-NMYALKRMFIQ-ERERLEAMKNEIDV
DDB0229350_Ddis KQIAEGGFSYVFLVKDSN--------------TSKHYALKRILIR-DEDELKGVKHEISI
Nak_Dmel DVLAEGGFAMVFLARGNGGG----------SSSATKYALKRMYVN-NEHDLNVAKREIQI
AKL1_Scer NYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQ-DENGLNEMRNEVEV
ARK1_Scer KYLTSGGFAQVYSALINPPD---------PHSNSSVACLKRVIVP-DKPSLNTLRAEVDA
PRK1_Scer KYLTSGGFAQVYTAEISPPD---------PYSNANIACLKRVIVP-HKQGLNTLRAEVDA
AAK1_Spur ------------------------------------------------------------
AqueK170_Aque DVIAEGGYAIVLEVKCTA-------------GTNERLALKRVAVN-SEQDLYLCRQEIAI
BIKE_Hsap MKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TGFTEP
AAK1_Hsap MRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TGFTEN
BIKE_Mmus MKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TGFTES
AAK1_Mmus MRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TGFTEN
sel-5_Cele LKQCIGHKNIVEFVDSYTNCL-GN--GIWECMLLTEYHQ-KNVLQLMNERISQNQYLTND
DDB0229347_Ddis MQKLRNNPNIVKLEGFKINEN-RNT-RETEVLMLMEYCSGGSVLDIMNARGEF-TRLEER
DDB0229350_Ddis MKRLTKHKNIVKILDYHKVS---DK-NNTEMFILMEYCSGGHLVEIMQKRLSSGSKFTDQ
Nak_Dmel ASNLSGHKNIIGYVDSSITPT-GN--GVCEVLLLMPYCKH-HMLAMMNARLH--VGFTEP
AKL1_Scer MKKLKGAPNIVQYFDSNASRR-RDGVQGFEVLLLMELCPNKSLLDYMNQRLS--TKLTEA
ARK1_Scer MRLLKNNRYVVSYIDSHAAKAMLHN-GSYEVFVLMEYCERGGLIDFMNTRLQ--NRLHEF
PRK1_Scer MKLLRNNKHVVSYIDSHAARS-VNG-IAYEVFVLMEFCERGGLIDFMNTRLQ--NRLQES
AAK1_Spur --------------------------------------TDGHVVQQMNERLS--VGFTEQ
AqueK170_Aque LKALSDSPNSVTYLASQINKL-SR--EVYEVLILMQLYGGQTGLQLIRQYHGQGKRLPEA
: :. : :
BIKE_Hsap EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--GGNYVLCDFGSATNKFLNPQ-
AAK1_Hsap EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQNPQ-
BIKE_Mmus EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--AGNYVLCDFGSATNKFLNPQ-
AAK1_Mmus EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQNPQ-
sel-5_Cele EILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQILSVE-
DDB0229347_Ddis EILAIFSDVCNGVLAMHQQQPPIAHRDLKIENVLYCE-HSNRYKLCDFGSSTIKTFNT-A
DDB0229350_Ddis EILKIFQDICESVAYMHSQQPLIIHRDLKVENVLLDE-ESGIYKLCDFGSATEEITRMKN
Nak_Dmel EVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTD--AGNFVLCDFGSATAKTLNPQ-
AKL1_Scer EIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDA--KNNFKLADFGSTSTCFPIVTT
ARK1_Scer EILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISA--NNEYKLCDFGSVCGIIRPPRN
PRK1_Scer EILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISH--DGLYKVCDFGSVSGVIRPPRN
AAK1_Spur EVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHR--SGNYMLCDFGSATGRVLDPK-
AqueK170_Aque LILKIFTDVCLAVSRLHHRTKPIIHRDLKVTLLQM---------------------DPK-
:: *: : .: :* : ***:*: :
BIKE_Hsap KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES-
AAK1_Hsap TEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-
BIKE_Mmus KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES-
AAK1_Mmus AEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-
sel-5_Cele KYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPFEES-
DDB0229347_Ddis T-ERGKAEDDINMFTTLFYRAPEMVDLYRGQIIDEKVDVWALGCLLFKMAFYVDPFDGG-
DDB0229350_Ddis KTEMQNAEDDISRHTTLQYRAPEIVDFYRSPVINEKIDIWALGCLLYKLLFYVTPFEDSG
Nak_Dmel QHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGES-
AKL1_Scer HQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPFEMTG
ARK1_Scer SQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGG
PRK1_Scer TQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSG
AAK1_Spur VHSINDIKDEIEKYTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFGES-
AqueK170_Aque EVGVGECQDQLQKFTTLAYRAPEMVDLYSGYTISTKSDIWALGCLLYKFCFFDTPFGEQ-
:: ** **:**::: : * * *:**** :*::: :: **
BIKE_Hsap QVAICDGNFTIPD-NSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNI
AAK1_Hsap QVAICDGNFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNV
BIKE_Mmus QVAICDGSFTIPD-NSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSNI
AAK1_Mmus QVAICDGSFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNV
sel-5_Cele PLAIQSVNYQFPS-VPNIPDEIKVLIYMLLDIDVNRRPSIYQTSVLAFEANHRKPLSEEI
DDB0229347_Ddis SLQIINNNYKIPD-NSKYSNNFHKLIQFILVADPTQRPSINDLLNYLNEIRGSSRRGL--
DDB0229350_Ddis SLGILNSNYTIPP-NHTHSNDLISLIKIMLNPDPINRPNIFEITNQLNLLRNQ-QPLFPS
Nak_Dmel TLAIQNGQFSIPD-SSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNL
AKL1_Scer QFAILHSKYEFPV-N-KYSSKLINLIIIMLAENPNLRPNIYQVLYHLCEILNVEVPIEDK
ARK1_Scer DLAILSGKFEFPL-YPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDI
PRK1_Scer EAGILHARYQYPS-FPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEVSRLQNKPCPIRNF
AAK1_Spur SLAIQSGNFTIPD-NTKYSREMHALIRYMLEVDAEKRPDIFQVSHVAFKAASSETPIQNL
AqueK170_Aque TLAIMRGTFSFPADASNYSNGLLGLIKYTLNTDPNKRPDIFQVSWVAYKLAGKDCPIVNV
* : * . . ** * **.: :
BIKE_Hsap NNS------------------------------------------------------SIP
AAK1_Hsap QNS------------------------------------------------------PIP
BIKE_Mmus NNS------------------------------------------------------FLP
AAK1_Mmus QNS------------------------------------------------------PIP
sel-5_Cele QNKKCTDAV---------PSLKSCIQLMRDGSNP---RNKRDSSPRN-------------
DDB0229347_Ddis ---QT--------------------FSSNNNNSN----NNSNNNSNNNSNNNSVNNSSNS
DDB0229350_Ddis HKSNI--------------------LLSYNENNN---INNNNNNINNNNNNNIVNGKNIP
Nak_Dmel HKT------------------------------------------------------PIP
AKL1_Scer YAEGAYNFSKYTQFQNKLQNVQ--LQMYQLQQKKIMQNNKLSDSEENLLNDMFLSSFEIS
ARK1_Scer QVV------------------------------------------------------QAP
PRK1_Scer YLL------------------------------------------------------RAM
AAK1_Spur HKS------------------------------------------------------PVP
AqueK170_Aque FNS------------------------------------------------------PIP
BIKE_Hsap SAL--PEPMTASEAA-ARKSQI-KARITD---TI--GPTE-TSI------------APRQ
AAK1_Hsap AKL--PEPVKASEAA-AKKTQP-KARLTD---PI--PTTE-TSI------------APRQ
BIKE_Mmus STL--PEPMTATEAA-ARKSQM-KARITD---TI--GPTE-TSI------------APRQ
AAK1_Mmus AKL--PEPVKASEAA-VKKTQP-KARLTD---PI--PTTE-TSI------------APRQ
sel-5_Cele -PE--APPIQSSSKM-ASLSQQ-VPSISNISMPSGSGTVE-TSV------------APRL
DDB0229347_Ddis IN--RPIRTSS---------------------------------------------SSNS
DDB0229350_Ddis KP--LPKVVSQTTPT--------------------P--TP-PPP------------APSQ
Nak_Dmel NFDLLVVPPFESEAKRISAAAS-KAAKAQ-NVSV--VEAG-TSV------------APRS
AKL1_Scer S--KLPMNA--SDGH-AAVSRIPSQNVGQE-L----EEEK-ESQSDQRKSTLSEDKSSRT
ARK1_Scer SSH--LNLTELHQLS-A-------TQ------NI--L---SLNS------------P---
PRK1_Scer NQN--ANTQLAGEPS-STTYV-PTQK----FIPV--QSLQSINQ------------PPNM
AAK1_Spur DGNKLPLPLTESEQR-QQHSRS-KTNNQN-RTPAGPMEVS-TSV------------TPRQ
AqueK170_Aque SVL--DMPMQLVKPK-ATKTLS-VSETTD-SNST--------------------------
BIKE_Hsap RPKA-NS-AT-------------TATP-SVLTIQSSATPVKVLA-P----GEFGN---HR
AAK1_Hsap RPKA-GQ-T--------------QPNP-GILPIQPALTPRKRAT-VQPPPQAAGS---SN
BIKE_Mmus RPKA-NS-T--------------AATS-SVLTIQSSATPVKVPA-P----GEFSN---HK
AAK1_Mmus RPKA-GQ-T--------------QPNP-GILPIQPALTPRKRAT-VQPLPQAAGP---SN
sel-5_Cele RPKA-TT-V--------------VPNVPSISPVPPVGLPHLRLPSKGSTDETDGS---QV
DDB0229347_Ddis TPNF-N-SPNTNNNNYNNNNNNS--KN-YGN--TPNST----------------------
DDB0229350_Ddis SPSP-SPSPTVVNNIENNSNGLEHSNS-NGNISQPSPTPPKRRATPGTTPS-LQP---VS
Nak_Dmel RPKG-SS-SVH------------GGNP-LGLGLPPSPSPRQNITSPQPQPQPVVEQFQAN
AKL1_Scer TSNA-NS-SGT------------ANNPQEINTIQSPGIEDK----------SIFE---NK
ARK1_Scer --TTMEN-T--------------MPN--ATFQISMADNTTTA-Q-M--------------
PRK1_Scer MPVTHVS-T--------------TPNL-GTFPISINDNNKTEVT-AHAGLQVGSH---SN
AAK1_Spur RPKA-SQ-QGV------------APAAGGISLPTPSSITRQRSS-KQGQPPTTGP---TV
AqueK170_Aque ---------P-------------TPSP-SVM---------KRTTS-Q-QPT---------
BIKE_Hsap PK----------------------------------------------------------
AAK1_Hsap QP----------------------------------------------------------
BIKE_Mmus PK----------------------------------------------------------
AAK1_Mmus QP----------------------------------------------------------
sel-5_Cele R-----------------------------------------------------------
DDB0229347_Ddis -PPNAKKNIFDILGDDT-TSSTSNSNNSPSVSRNNINNNSNNFNNNNNNNNNNNNNNNNN
DDB0229350_Ddis FPPNNSNNSFDDPFRDSPRT---------NLSNNPFNVNSNDNSNSSN-----NNNNNNN
Nak_Dmel FP----------------------------------------------------------
AKL1_Scer TP----------------------------------------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer L-----------------------------------------------------------
AAK1_Spur AA----------------------------------------------------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ------------------------------------G------AL-----------RPGN
AAK1_Hsap ------------------------------------G------LL-----------ASVP
BIKE_Mmus ------------------------------------G------AL-----------RPGN
AAK1_Mmus ------------------------------------G------LL-----------PSVS
sel-5_Cele ------------------------------------K------VPIDFHHRQSFSGEEQL
DDB0229347_Ddis NNNNNNNNTNNNNSNNNN--------YNNNN-----------------------------
DDB0229350_Ddis NNNNNNNNNGNNITNEEILNIITQLTNNDQTNTFDSGLLLKLKSM-----------KPGK
Nak_Dmel ------------------------------------A------MP-----------PAVP
AKL1_Scer ------------------------------------G------EL---------YYPSVS
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur ------------------------------------A------AQ------------RLS
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap GPEILLGQGPPQQP-------------PQQHRVLQ----QL---QQGDWRLQQ---LHL-
AAK1_Hsap QPK---PQAPPSQPLPQ-TQAKQPQAPPTPQQTPS----TQ---AQGLPAQAQ---ATP-
BIKE_Mmus GSEVLMVQGPPQQP-------------PQQHRVLQ----QL---QQGDWRLQQ---LHL-
AAK1_Mmus QPK---AQATPSQPLQS-SQPKQPQAPPTPQQTPA----TQ---TQGLPTQAQ---ATP-
sel-5_Cele KPA---AEADSAGPLSC-PLIKPTDLGFTDLDKPA-------LPRDRAQTD---GKRRL-
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis GTMHIIVKRPLKEP-------------LVCFKSLLLVHALL---SEGNNIQFK---SD--
Nak_Dmel PPP---QAVTPAAPAAS-KLFES-SGYPDPFNEPA----AAVIPTEFLPAAEEPNKEEV-
AKL1_Scer E---------LDTYLDK-ELVKQSSDPTISEQSPR----LN---TQSLPQRQK---STSS
ARK1_Scer --------------------------------HPN----RK---PSQIAYDAS---FSN-
PRK1_Scer -----------T--------------------SPL----MK---TKSVPLSDE---FAS-
AAK1_Spur PPQV-QAQQAIQQQ-------------QQQQQQQQ----QQ---QQQLLQEQQ---LAQ-
AqueK170_Aque ---ITL---------TSISSRERPRSRPISSISPA----SS---SSY-------------
BIKE_Hsap ------------------------------------Q---HRH-----------------
AAK1_Hsap ------------------------------------Q---HQQ-----------------
BIKE_Mmus ----------------------------------------HRH-----------------
AAK1_Mmus ------------------------------------Q---HQQ-----------------
sel-5_Cele ------------------------------------P---HES-----------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------V---HDSKDL--------------
Nak_Dmel ------------------------------------P---QDL-----------------
AKL1_Scer YSSGGRSMKSTSYGAATIGSDEALANEKTAGINKMKQ---HKSNNPFPKMNVAYHSTNEL
ARK1_Scer -------------------------------------SAKGSQ-----------------
PRK1_Scer ------------------------------------LYYKELH-----------------
AAK1_Spur -----------------------------------QQ---NKQ-----------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ------PHQQQQQ---------------QQQQQQQQQ-----------------------
AAK1_Hsap ------QLFLKQQ---------------QQQQQPP---PAQ---------------QQPA
BIKE_Mmus ------PHHHHQQ---------------QQQQQQQQQ-----------------------
AAK1_Mmus ------QHLLKQQ---------------QQQQQQPQQPTAP---------------PQPA
sel-5_Cele ------DIIFQQQ---------------HRRNVSD--TSQI---------------SRSA
DDB0229347_Ddis ------NKFDEFE-----------------------------------------------
DDB0229350_Ddis ---FN-NLYLGWS---------------KQKDRYLQ------------------------
Nak_Dmel ------NVIAGTPTKSMLTPPKPSGGGGHRRNVS--DTSAF---------------NK--
AKL1_Scer SNDAS-NFFLEEQ---------------QQGQRYQQAQ-NQT------GT---QGNTFPD
ARK1_Scer ------PL-FDKS-----------------------------------------------
PRK1_Scer ------P--FQKS---------------QTFK----------------------------
AAK1_Spur ----RLLALAQQQ---------------QQQQQQQQQQ--QQLAYNNAQAQAAYGPQQPQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ----QQQ--QQQQQQQQQQ-----------------------------------------
AAK1_Hsap GTFYQQQQA------QTQQ-----------------------------------------
BIKE_Mmus ----QQQ--LQQQQQQQQQ-----------------------------------------
AAK1_Mmus GTFYQQQQQQQQQQAQTQQ-----------------------------------------
sel-5_Cele FKPYSSQQT--TSKTSSQV-----------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel -TFA--------------------------------------------------------
AKL1_Scer ESQYQSRVEQQQQQQDQPKGPANYSQRNFYTGRDRSNKPMQLGGTIAGDSGNRRVNFQNI
ARK1_Scer ---------------Q-NM-----------------------------------------
PRK1_Scer ----SVES------FQSPQ-----------------------------------------
AAK1_Spur QVAYAGQQG------FQQP-----------------------------------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap --------HHHHH-----------------------------------------------
AAK1_Hsap --------FQAVHPATQKPAIA----------------------QFPVVSQG--------
BIKE_Mmus ------------------------------------------------------------
AAK1_Mmus --------FQAVHPAAQQPVTA----------------------QFPVGSQG--------
sel-5_Cele --------VRSVEDMSQ-------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel ------------------------------------------------------------
AKL1_Scer SQNYATNSQSGYLPSQNSPAIP---------------------MVRPVISMN--------
ARK1_Scer --------YHALDPPLVEPLAS----------------------SV--SN----------
PRK1_Scer --------RKSMPPLSLTPVNN----------------------DI--------------
AAK1_Spur --------YQQPQPTPQQPAFGQHGAFTRPQQLTYEQQQASIQAQYAQQQAALQQQQQQA
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---------HHHLLQDAYMQQY----QHA----------TQ-----------QQQML---
AAK1_Hsap -------GSQQQLMQNFYQQQQ----QQQ----------QQQQQQQLATALHQQQLMTQQ
BIKE_Mmus ------------LLQNAYLQQY----QHA----------MH-----------QQHIL---
AAK1_Mmus -------GAQQQLMQNFYHQQQ----QQQ----------QQ-----------QQQLMAQQ
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ---------LGELLSHYSLLL---------------------------------------
Nak_Dmel ------------------------------------------------------------
AKL1_Scer -------QQQAQQIQAQQLQAQ----QMQ----------AKQQMQAKQQMQVQQQLQVQQ
ARK1_Scer ----------------------------NDNELKANSATKL-----------KQAIVSEA
PRK1_Scer -------------------------------FDRVSAINRP-----------NNYVDSET
AAK1_Spur ALQQQQQAALQQQQQAAYQQQQQALLQQQ----------QQQQQQQQAAYLSQQAALEQQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---QQQFLM-------------HSVYQPQP--------SASQ--YPTMMPQYQQAFFQQQ
AAK1_Hsap AALQQKPTM-------------AAGQQPQP--------QPAA--APQPAPAQE--P-AIQ
BIKE_Mmus ---QQQFLM-------------HSVYQPQP--------PASQ--YPAMMQQYQQAFLQQQ
AAK1_Mmus AALQQKTAV--------------VVPQSQA--------QPAT--APQAAAAQE--PGQIQ
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ---YKFILFHQKNYMIDGSFAFEEMKWGIPESLDSNNHPISINTIKALFDIMDHLFLVQN
Nak_Dmel ------------------------------------------------------------
AKL1_Scer ------------------------------------------------------------
ARK1_Scer HTFRQNNSI--------------D------------------------------------
PRK1_Scer QTIDN---M--------------A------------------------------------
AAK1_Spur AVLQQQQLAYQQQQQLAAQQQQYQASSP-P--------PFSQ--QPQFIPSEQQALYQQQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap MLA-Q-------------------------------------------------------
AAK1_Hsap APV-R-------------------------------------------------------
BIKE_Mmus MLA-R-------------------------------------------------------
AAK1_Mmus APV-R-------------------------------------------------------
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ----------------SWGNTPLQHP----SPSNSNS-N--VIIN---------------
DDB0229350_Ddis NLSDYCINNICSSNSSGSGNVPISLLQHCVNILNSSSYSIFCFISGSIDVLSKQFSDVDM
Nak_Dmel ------------------------------------------------------------
AKL1_Scer ------------------------------------------------------------
ARK1_Scer --------------------FPL-------------------------------------
PRK1_Scer --------------------VPN-------------------------------------
AAK1_Spur QAALQ-------------------------------------------------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap --------HQPSQ---------------QQASPEYLTSPQEF------------------
AAK1_Hsap --------QQPKV---------------QTTPPP-AVQGQKVG-SLTPPSSPKTQRAGHR
BIKE_Mmus --------HQQPA---------------QQVSPEYLTSPQEF------------------
AAK1_Mmus --------QQPKV---------------QTTPPP-TIQGQKVG-SLTPPSSPKTQRAGHR
sel-5_Cele --------RQNGG---------------S-------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis KLISCVNQFQSMY---------------TRLRE---------Q-YTKLAQ------VP--
Nak_Dmel ---------------------------------------NET------------------
AKL1_Scer ---------QMQI---------------QNAN----------------------------
ARK1_Scer ------------QNIIPQYEDSSSSSDESYS-----------------------------
PRK1_Scer ------------LKLSPTITSKSLSSTKEIAAPD-NINGSKIVRSL--SSKLKKVITGES
AAK1_Spur --------QQQQQ---------------AQQQQQFLQAQ-----------A---------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---SPALVSYTSSLPAQVGT---------------------IMD-SSYS-ANRSVADKEA
AAK1_Hsap RILSDVTHSAVFGVPASKSTQLLQ--------A-------AAAE-ASLN-KSKSATTTPS
BIKE_Mmus ---SPALVSYASSLPAQVGT---------------------IVD-SSYG-ANRSVAEKEA
AAK1_Mmus RILSDVTHSAVFGVPASKSTQLLQ--------A-------AAAE-ASLN-KSKSATTTPS
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis -CFSDI---FFPTLPN----TAPT--------F-------TIVRSNSFNRLNSSLSDLNL
Nak_Dmel ---SQFLAPFNNNL------AA-MGDGQQTLASAASNPGIYASS-TANS-AAVSIS----
AKL1_Scer ----------------NNGT---------------------------YV-SDRTNHTTED
ARK1_Scer -----------GDVDELKKTRSLG--------S---------------------------
PRK1_Scer RGNSPIKSRQNTGDSIRSAFGKLR--------H-------GFTG-NSVN-NSRSAS----
AAK1_Spur ----QALA--QAQAAGAVGT---------------------LVE-VDAA-DH--VSPVQD
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap IANFTNQKNISNPPDMSGWNPFGE--D-------------NFSKLTEEELLDREFDLLRS
AAK1_Hsap GSPRTSQQNVYNPSEGSTWNPFDD--D-------------NFSKLTAEELLNKDFAKLGE
BIKE_Mmus VANFTNQKTISHPPDMSGWNPFGE--D-------------NFSKLTEEELLDREFDLLRS
AAK1_Mmus GSPRTSQQNVSNASEGSTWNPFDD--D-------------NFSKLTAEELLNKDFAKLGE
sel-5_Cele ----------------GEWNPFLV--APFSNNSISRKDGQESAFMMDDSHFGMVFDEIRR
DDB0229347_Ddis -------NTNS-----SGKNNQNKSNS-------------GNGNF---------------
DDB0229350_Ddis -NNNNNNNNNS-----NNSNNSNN--S-------------NSGNLSGNASLNSSFDNINS
Nak_Dmel --ELMKPGQTAVEKRVEAWNPFEE--E------------QPFSQMTEDHIFEAEFDKIRQ
AKL1_Scer MRNAQ----GGEPPILAG-NSANE--PMHS-------------S-SKNEALLIELSPLKE
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur LA--------------SPTNPFSP--Q-----SAMLA--SQLPAPPDDEDLDSEFDQLRK
AqueK170_Aque ----VSEQ----------------------------------------------------
BIKE_Hsap NRLEERASSD---KNVDS-LSAPHNHPPEDPFGSVPFISHSGSPEKKA--EHSSIN----
AAK1_Hsap GKHPEKLGGS-----AES-LIPGFQSTQGDAFATTSFS--AGTAEKRK--GGQTV-----
BIKE_Mmus NRLGASTPSD---KTVDL-PPAPHSRPPEEPFASVPFISHSGSPEKKT--TEHSPN----
AAK1_Mmus GKLPEKLGGS-----AES-LIPGFQPTQGDAFTTPSFS--AGTAEKRK--GGQAV-----
sel-5_Cele KEIPAELD--SETS----------SIDSRDPFGAAPFDQLTVSTSSSA--QPVSLPPATD
DDB0229347_Ddis ------FDND---FEFEG-FVSPTTNGSTNFEVNTTNTNVSLNSSTHS--SSSFNN----
DDB0229350_Ddis SNP---FSTE---PTFNP-FSATTTNTSESGFGNFGLSEPTSNPSPRY--QQSNNN----
Nak_Dmel RGSQGTAPGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKAS--SLRKTG----
AKL1_Scer DAGKQS-FQDT---------NEPQTGGIEDAGGS--------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur VSPETATN--VAQPQIQGISNPP---HTTDVFGAVPFNLREGRPQSGGAAEMEQIA----
AqueK170_Aque ---------------------------------------------KKP--P---------
BIKE_Hsap -----------------------QENGTANPIKNG--K----------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus -----------------------QKSITANLTKNG--G----------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele EDDERQLLSETDEEEKYEIDEKEEIQTKKDETINE--E----------------------
DDB0229347_Ddis -----------------------SSNNNNTNNSSV--S----------------------
DDB0229350_Ddis -----------------------NNNNNNNNGTPI--S----------------------
Nak_Dmel -----------------------AKFIGVSSGGTGGGV----------------------
AKL1_Scer -----------------------------------------------------------G
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur -----------------------SGTGSQQTLVQG--HVMESSPPLVGGEGEARKGGHMD
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---TSPASKDQR------------------------TGKK-TS-----------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ---SSPLCKDQR------------------------AGKK-TS-----------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele ---DSEI-DEQR------------------------MNDRRRY-----------------
DDB0229347_Ddis ---VG--SSI--------------------------------------------------
DDB0229350_Ddis ---LTPGSLS--------------------------------------------------
Nak_Dmel ---ATPIG--LVAGGANTATSSNSSKWMLSPTLEVSSEEK-TSLISKLKTDSECGIPGAV
AKL1_Scer TI----------------------------------KGSN-NN-----------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------FDN---------------------------------------------------
AAK1_Spur VFGATPFG-------------LSGGGQAAQPSQ---------------------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap -----------------------VQGQVQKGNDESE---SDF------------------
AAK1_Hsap -----------------------------------D---SGLPLL---------------
BIKE_Mmus -------------------ENPVIRGQVQKGHDDSE---SDF------------------
AAK1_Mmus -----------------------------------D---SGIPLL---------------
sel-5_Cele -------------------SYENIDG----VGDDAS---SD-------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel GGAGEGVSGYVKLPVEDRNKYEKLRSKDQPTSDDSD---SEASEFFQQDSDEGGGGIFRQ
AKL1_Scer -------------------------RNGVLNLSLN-------------------------
ARK1_Scer ---------------------YSTRGNIKKNQSVKESLTS--------------------
PRK1_Scer ---------------------NNVNGNGNNT---NRRLVS--------------------
AAK1_Spur ----------------------TTQQQQQRHMSPQE------------------------
AqueK170_Aque -------------------------------NNMVQ---SS-------------------
BIKE_Hsap ------------------------------------------------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ------------------------------------------------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel MQMVTSNLPETIHKIQQVAYHKVDKTAHLPIVKKLRDKTKKPTTAAHQAAQQLNLMAAAV
AKL1_Scer ---------------------------------------------------EMDLS----
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur ----------------------------------------------------ADLLGAMA
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap -----------------------------------------------------------E
AAK1_Hsap ----------------------------------------------------------SV
BIKE_Mmus -----------------------------------------------------------E
AAK1_Mmus ----------------------------------------------------------SV
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel AAQAEEAAK------------------------------------------------AAE
AKL1_Scer ---------------------------RDDTGAAVSSFSSSSSSAS-------------I
ARK1_Scer ---------------------------------------SSLPG---------------T
PRK1_Scer ---------------------------------------SS--T---------------S
AAK1_Spur TEPQPESASTPRIRVGFEDDFVREGKQEGRSER---LTSTGSSSGGFNLERSIRELDEFG
AqueK170_Aque -----------------------------------------------------------F
BIKE_Hsap SDPP----------SPKSS-EEEEQDDEEVLQGEQGD--FNDDD--------T-----EP
AAK1_Hsap SDPF----------IPLQV-PDAPEK---LIEGL--------------------------
BIKE_Mmus SDPP----------SPKSS-EEEQEDED--AQGEHGD--FNDDD--------T-----EP
AAK1_Mmus SDPF----------IPLQV-PDAPEK---LIEGL--------------------------
sel-5_Cele SRGK----------TDRDD-SEEEEDDDS-RR--GGDTSHDEDS--------QNTVGSED
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel SDGD----------SIGSA-SD--------LRAEDDD-LFDENP--------R-----QT
AKL1_Scer QQAKLSGRKGSSKR-NNYS-TDELG-DSM-VSSESID--IDLDD--------A-----RR
ARK1_Scer SFTP----------TSTKVNLK--------------------------------------
PRK1_Scer SFPK----------FNSDTKRKEESDKNQRL-----------------------------
AAK1_Spur AKPF--GSVRQHRGSESSS-D----HEGERLSSSLRD--FSYDTFDSDSIDIR-----KD
AqueK170_Aque KDPL----------P---------------------------------------------
BIKE_Hsap ENLGHRPLLMDSEDE----------------------EEEEKHSSD-SDY----EQAKAK
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ENLGHRPLLMDSEDE----------------------EEDDKHSSD-SEC----EQAKTK
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele GEGGSRPLLEDDGLE----------------------D-DDDHELI-SSF----SSS---
DDB0229347_Ddis NNSGTRLMNNSSGSLP------QSRQ--SSFN-----------STP-QQ-Q----QQQFN
DDB0229350_Ddis PVIGAK-----KPPLPPNIHHLQQQQHPQQQQQQQQQQQQQQQQQQ-QQQQ----QQQQQ
Nak_Dmel QAKQRRPLPTEMDGI----------------------SESVKTCSS-SAYHAECESVTTH
AKL1_Scer GKTAERRPLHNERGH----------------------K-DQARSSDASKS----NQFKSK
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur EEHAHRGLLDQEESS----------------------EDESDD-----------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap YSDMSSVYRDR-SGSGPTQDLNTILLTSA--------QLSSDVAVETPK--QEFDV-FGA
AAK1_Hsap --------------KSP----DTSLLLPDLLPMTDPFGSTSDA--VIEK--ADVAV-ESL
BIKE_Mmus RGDTSSLRRDK-PGVAP----DTALLTPA--------RSPADA--LTPS--QEFDV-FGA
AAK1_Mmus --------------KSP----DTSLLLPDLLPMTDPFGSTSDA--VIDK--ADVAV-ESL
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis SSTNSGSYNNL-TSS---------------------------------------------
DDB0229350_Ddis HPQQQGLRFPH-SASLEDAR----------------------------------------
Nak_Dmel EDDVRSRVVVKVRMRKKD----RALVTAT-----GDPSAPSEE--LSPTSSDLLHK-FGD
AKL1_Scer --DFSSV------------------------------------STRQPR--QSLDLNFQE
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur -----------------------------------------------DSDHHDFDE-VGA
AqueK170_Aque ------------------------------PPPT--------------------------
BIKE_Hsap VPFFAVRAQQP--QQEKN-EKNLPQHRFPAA-----------GLEQEEFDVFTKAPFSKK
AAK1_Hsap IPGLEPPV----------------------------------------------------
BIKE_Mmus VPFFAAPAPQS--LQHRGDGKNLSQHAFP---------------EQEDFDVFTKAPFNKK
AAK1_Mmus IPGLEPPV----------------------------------------------------
sel-5_Cele -----------ST-------------NYPPLFIGTST----PHTQNPITNP---------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel RPLLLDDELDYGSGESKS------STESPVAPI----LPTNPDVQESEEDVFALAPFKLP
AKL1_Scer VNLS--------------------------------------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------EKRRSMPPSILSDFDQHERNNS-----RTG
AAK1_Spur QPLIGDDGHGLSDAELASL-NL--HEDLPSQKVRKSEPPVAQLIDMTDDDPFSQAPFKAK
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap VNVQECHAVGP---EAHTIPGYPK------------------------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus VSVQDWPAVGP---DARPLPARPR------------------------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele -----------F----LRDELTPKMIITAPLPTAKNNLDDDWDLGDRWTDRRDTVFERP-
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel VGVPLKRKTKP---KAKPKPSEPEMWTSTPVKSAAV--------GDPS-----TNF----
AKL1_Scer ------------------------------------------------------------
ARK1_Scer ------H-----------------------------------------------------
PRK1_Scer SRDY-YR-----------------------------------------------------
AAK1_Spur TGS-LKRATEPVGMCALTPPISPPMQEEDPFGEAPF--------N-PR-----SGFERET
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ------------------------------------------------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ------------------------------------------------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele -----ASEHQNVFAPATLPRQATPLVCRFKPDLPTAAPVSIIPSMSNT------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel ----------------------------------ASFPAQ-LTPTNNVGNSA--------
AKL1_Scer ----------SPTLTQEHR-----------------------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur SKSSVGSTGS---------------------DVFSKAPFL-VSSKKRQGTGSEVRRAKTQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap --SVD--VF--GSTPFQPFL-----TSTSKSES----NEDLFGLVPFDEITG--SQQ---
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus --SVD--IF--GSTPFQPFS-----VSASKSES----KEDVFGLVPFEEITG--SQQ--Q
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele ----------------------------SFPEA----VRDS-DTVPCEPII--GTLI--S
DDB0229347_Ddis ---------------FNNLN-----ISTSS------------------------------
DDB0229350_Ddis ---------------LYTLI-----LTPSS------------------------------
Nak_Dmel --QLD--EF--NEPIFNPFQ-----ENAQNTQSGETNQCDLFGLEPFPQVIR--TIE---
AKL1_Scer ---------NK-------------------------------------------------
ARK1_Scer -----------ENSPFKSTF-----VNT-IDNS----KDDLN-KPSYEDLDV--SKQNLK
PRK1_Scer -----------SHSPVKKTQ-----ASA-KTTS----KPTLI--PDNGNVNI--N-QEKK
AAK1_Spur HVSGEQTALGNPTPPISPTELGAQGVSSKMSKQ----EPDMFGAVPFHAVASHGSDL--E
AqueK170_Aque ---------------------------------------DL-------------------
BIKE_Hsap QKVKQRS-------LQK----LSSRQRR-TKQDMSKSNGKRHHGTPTS------------
AAK1_Hsap --------------PQR----LPSQTE---------------------------------
BIKE_Mmus QKVKQRS-------LQK----LSSRQRR-TKQDVSKSNGKRHHGTPTS------------
AAK1_Mmus --------------AQR----LPSQTE---------------------------------
sel-5_Cele V--GAPTDPPPPPLPKKPTEASPTQET------------------TAT------------
DDB0229347_Ddis ------------------------------SASIS-SSGGVSNNSDNS------------
DDB0229350_Ddis ------------------------------SPPLSPSTGPTTAAQQQQQQQQSQHTFDNF
Nak_Dmel QNPQHHQ-------IHQ----FPSHNNN---NNVIKVPASVSVALPAS------------
AKL1_Scer -------NDSPAPNSHHSYRVSPHAST---------------------------------
ARK1_Scer NSIQQRM-------IDK----LNSSEESFN-----------------A------------
PRK1_Scer ESIQRRV-------HNL----LKSSDDPVTYKSASGYGKYTDIGTETS------------
AAK1_Spur MSSKEDA----------------------------QQPGPASHKRPHV------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---TK-K--TLKPT---------------YRTPERARR------HKK-VGRRDSQSSNE-
AAK1_Hsap -----------------------------------------------------SVTSNR-
BIKE_Mmus ---AK-K--TLKPP---------------YRTPERARR------HKK-VGRRDSQSSNE-
AAK1_Mmus -----------------------------------------------------SVTSNR-
sel-5_Cele ---IP-VALGKKEK---------------LLKKE-KKK------EKK-DGKKDKLKLEE-
DDB0229347_Ddis ---WN-V--TLTPS---------------QSNKNSTGNLKPLNNNNNNNNNNNNRF--AN
DDB0229350_Ddis NINGH-A--PPVPQ---------------STQPSFQPHVSF-APNVNINNNNNSHVSAPH
Nak_Dmel ---VP-V--SVSVNSSAPQLVTINHSIIINKTPEPPMN------YNN-NNNNQTAKSSG-
AKL1_Scer -----------------------------------------------------AITENK-
ARK1_Scer ---RKMS--KVKL-----------------------------------------------
PRK1_Scer ---NRHS--SVRIT---------------PITEEKFKK----------------------
AAK1_Spur ---VS-TAVGVRRS---------------SRTSSGGRR-------RR-SGSNSSRSSRR-
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap -FL--------TISDSKEN--ISVA-LTD---GK-DRGNVLQP-EESLLDPFGAKPFHSP
AAK1_Hsap -TDSL------TGEDSLLD--CSL--LSN-------------P-TTDLLEEFAPTAIS--
BIKE_Mmus -FL--------TISDSKEN--ISVA-LTD---GK-DRASVLPS-DESLLDPFGAKPFHPP
AAK1_Mmus -TDSL------TGEDSLLD--CSL--LSN-------------P-TAGLLEEFAPIALS--
sel-5_Cele -YR--------EKGSSEPETDGSEA-EIW---TN-DGATTFSN-KKKKKSTF--------
DDB0229347_Ddis NTNSSRDYSFDF----SSP--N--T-SNN----N-DFGSFVQPSSSSSLNT---THFSKP
DDB0229350_Ddis SLNSSS----------SSI--S--S-ISN----P-NLGGIAQKGSGNSLMP---PPLYKP
Nak_Dmel -TSSVYVNVPSFSSMSTSS--C--S-INQ---PQSSPAAVIPV-QAPLPVPV-PAPVSVP
AKL1_Scer -RHST------GHE-------LST--RS--------------------------------
ARK1_Scer ------------HEKGEID--KPTMLKSSGPISK-DKK----------------------
PRK1_Scer -----------TLKDGVLD--IKT--KSN---GK-DKS----------------------
AAK1_Spur -SS-----------SSSAS--NSLK--SS---PGSQP--RLRG-SQDSLDAFGSRPFSLA
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap -------------------------------------DLS------------------WH
AAK1_Hsap -----------------------------------------------------------A
BIKE_Mmus -------------------------------------DL-------------------WH
AAK1_Mmus -----------------------------------------------------------A
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis -------------------------------------NYNVNLN----------------
DDB0229350_Ddis -------------------------------------AARGHRRSQSSNGDEVRRRNLLQ
Nak_Dmel AVPVPIPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDE------------------EE
AKL1_Scer ------------------------------------------------NGKHETHRTG--
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur -------------------------------------DD---------------------
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap PPHQGLSD--IRADH--------------------NTVLPGRPRQNSLHGSFHSADVLKM
AAK1_Hsap PVHKAAED----------------------------------SNLISGFDVPEGSDKVAE
BIKE_Mmus QPHQGLSD--ICVDH--------------------TTILPGRPRQNSVHGSFHSAETLRM
AAK1_Mmus PTHKAAED----------------------------------SNLISGFGVAEGSEKVAE
sel-5_Cele ----------------GLRSS---------------------------------HPSIVA
DDB0229347_Ddis ---QTTSMTNNYNNN--------------------NY--------NNNNNSNNNN-----
DDB0229350_Ddis ---QQLEQNRDFLNH--------------------NRLLNKQSRMNNPNNLFDEGDS---
Nak_Dmel PVVLRDAD--VVADGIGIPTPAKPKKEKSNLA---VRVLPGKLTQKVKGHSYKKVS---A
AKL1_Scer ------------------------------------------------------------
ARK1_Scer --------------------------------------TKPTPPPKPSHL---KPKPP--
PRK1_Scer --------------------------------------RPPRPPPKPLHL---RTEIQKI
AAK1_Spur ---------------------GQPKPVDTKLTFEDTFGRKLTPPQS--HKQLVLPLTKAV
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap DD--FG-AVPFTELVVQSITP---------------------------------H---QS
AAK1_Hsap DE--FD-PIP--VLITKNPQG---------------------------------G---HS
BIKE_Mmus DD--FG-AVPFTELVVQSVTP---------------------------------------
AAK1_Mmus DE--FD-PIP--VLITKNTQG---------------------------------G---HS
sel-5_Cele NDLQFSSPMP--PVVKKSSK--------------------------------------DK
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ---------------------------------GFG------------------------
Nak_Dmel AA--LG-ST--SSLSSGSKQKHQRLQYQSHDDDDDEQDQDE------N-RGAGGGRNFQS
AKL1_Scer -----------------SKQRHDLERYRHSKDK-------------------------DS
ARK1_Scer -----------------PKPL---------------------------------L-----
PRK1_Scer RN--FS-RLQSKKLPIERISS---------------------------------E---AT
AAK1_Spur DD--FG-AQPFTSPDSPA-AP---PAGFDVDVDPFGAAPFKPPAISGPVKRQG-AR--RA
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap Q---QSQPVELD-----PFG----------------------------------------
AAK1_Hsap RNSSGSSESSLPN-LARSLL----------------------------------------
BIKE_Mmus Q---QSQPVELD-----PFG----------------------------------------
AAK1_Mmus RNSSGSSESSLPN-LARSLL----------------------------------------
sel-5_Cele KSSLTGKNASFVN-TSFQPE----------------------------------------
DDB0229347_Ddis -----------------NNS----------------------------------------
DDB0229350_Ddis -----------------DGE----------------------------------------
Nak_Dmel NTIQNSAKTGFSN-MSFEDFPSDQEMDRLSRTIPFEVVRNEKMLLEAEKKFGS------L
AKL1_Scer -NSSITISTSTPSEMRKSF-------ARARQSLDLERVRREAMASSASSSGGSNGKRRSF
ARK1_Scer ------------------L----------------------------------------A
PRK1_Scer E---TIVDVNVD-----DL-------------------------------------EADF
AAK1_Spur RESPGDEKSPEKM-SLASRQ----------------------------------------
AqueK170_Aque ------------------F-----------------------------------------
BIKE_Hsap AAPFPSKQ
AAK1_Hsap LVDQLIDL
BIKE_Mmus AAPFPSKQ
AAK1_Mmus LVDQLIDL
sel-5_Cele DHDDPTDL
DDB0229347_Ddis KVFDFGIL
DDB0229350_Ddis EEDEGLLN
Nak_Dmel KRRNNLFS
AKL1_Scer FSVFRSEK
ARK1_Scer GRKLSLDK
PRK1_Scer RKRFPSKV
AAK1_Spur RRSFQTDL
AqueK170_Aque ---GQAPF