CDK11a_Hsap MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
CDK11b_Hsap MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
CDK11_Mmus MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe MHLVRG------MD----LD-RDRPDNERNGVRAYIATDSRDIE----------------
CDK11_a-2_Smoe MSWVMD--------E------------------RSTSSRHRKSHRYSH------------
CDK11_b-1_Smoe MHLVRG------MD----LD-RDRPDNERNGVRAYIATDSRDVE----------------
CDK11_a-1_Smoe MSWVMD--------E------------------RSTSSRHRKSHRYSH------------
CDK11_c_Smoe MQRR--------------------------------------------------------
CDK11a_Hsap TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
CDK11b_Hsap TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
CDK11_Mmus TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe ------------------------------------------------------GDDGIS
CDK11_a-2_Smoe ----------------------------------------GDGRHHPYSHHHSSSSGGGS
CDK11_b-1_Smoe ------------------------------------------------------GDDGIS
CDK11_a-1_Smoe ----------------------------------------GDGRHHPYSHHHSSSSGGGS
CDK11_c_Smoe ------------------------------------------------------------
CDK11a_Hsap HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
CDK11b_Hsap HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
CDK11_Mmus HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe -------------RKRKY------------------------------------------
CDK11_a-2_Smoe -------------RRRHR------------------------------------------
CDK11_b-1_Smoe -------------RKRKY------------------------------------------
CDK11_a-1_Smoe -------------RRRHR------------------------------------------
CDK11_c_Smoe ------------------------------------------------------------
CDK11a_Hsap MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
CDK11b_Hsap MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
CDK11_Mmus LREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREEYSDKGKVGHWSRSPLRPPR
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe ---------------------------------------------------SPI------
CDK11_a-2_Smoe ---------------------------------------------------SPSPSKPLA
CDK11_b-1_Smoe ---------------------------------------------------SPI------
CDK11_a-1_Smoe ---------------------------------------------------SPSPSKPLA
CDK11_c_Smoe ------------------------------------------------------------
CDK11a_Hsap ER-FELGDGRKPGEARPAPAQ-KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
CDK11b_Hsap ER-FELGDGRKPGEARPAPAQ-KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
CDK11_Mmus ER-FEMGDNRKP--------------VKEEKVEERDLLSDLQDISDSERKTSSAESSSAE
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe --VWDLDDGKKSDAAPPLSRFSEAAAAGEDET----------QPIDTD--VLSSGGGGAQ
CDK11_a-2_Smoe TSLLQLEEQLTTAQ-----AQ-APAT-------------------TSQERAASVSCSDGE
CDK11_b-1_Smoe --VWDLDDGRKSDAAPPLSRFSEAAAAGEDET----------QPIDTD--VLSSGGGCAQ
CDK11_a-1_Smoe TSLLQLEEQLTSAQ-----AQ-APAT-------------------TSQERAASVSCSDGE
CDK11_c_Smoe ----------------P-CLYSEAAAAGEDET----------QPIDTD--VLSSGGG---
CDK11a_Hsap SGSGSEEEEEEEE-EEEEEGSTSEESEEEEEE-EEEEEEETGSNSEEASEQSAEEVSEE-
CDK11b_Hsap SGSGSEEEEEEEE-EEEEEGSTSEESEEEEEE-EEEEEEETGSNSEEASEQSAEEVSEE-
CDK11_Mmus SGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDE-
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe DNSGSRDEEQRYEQ-EL-------------------------------NEKELVELSDD-
CDK11_a-2_Smoe VAAVVTLEVADLEEE-----------------VVNEEAE--------MSEVKVVDVAETS
CDK11_b-1_Smoe DNSGSRDEEQRYEQ-EL-------------------------------NEKELVELSDD-
CDK11_a-1_Smoe VAAAVTLEVADLEEE-----------------VVNEEAE--------MSEVKVVDVAETS
CDK11_c_Smoe ----DKT------------------------------------------------IPGA-
CDK11a_Hsap --EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL
CDK11b_Hsap --EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL
CDK11_Mmus --EMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTEGDYVPDSPAL
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe --DGSAPDERS-------------G-SDSDYE-------------------DRSP-PPQL
CDK11_a-2_Smoe EAGLAKLD------------------DDGDLE-------------------QGVPHTPEV
CDK11_b-1_Smoe --DGSAPDERS-------------G-SDSDYD-------------------DRSP-PPQL
CDK11_a-1_Smoe EAGLAKPD------------------DDGDLE-------------------QGVPHTPEV
CDK11_c_Smoe --EMRSSDERL-------------G-SDLDYD-------------------DRSP-PPQL
CDK11a_Hsap SPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME-
CDK11b_Hsap LPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME-
CDK11_Mmus SPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME-
CDK11_d_Smoe --------------MLRGCRSVDEFERLNKIDEGTCGVVYRARDKKSGEIVALKRVKMD-
CDK11_b-2_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMD-
CDK11_a-2_Smoe QDVKC-------SSPCGKCRIVDEFEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHN
CDK11_b-1_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMD-
CDK11_a-1_Smoe QDVKC-------SSPCGKCRIVDEFEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHN
CDK11_c_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVLYRARDKKSGEIVALKRVKMV-
** *:**: *.:: **: **:*:*:**:: ******::**
CDK11a_Hsap KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV----
CDK11b_Hsap KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV----
CDK11_Mmus KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV----
CDK11_d_Smoe HEREGFPMTSVREINV-----------------------LLSFHHPSIVDVKEVSL----
CDK11_b-2_Smoe HEREGFPMTSLREINV-----------------------LLSFHHPSIVDVKEVVV----
CDK11_a-2_Smoe QETEGFPVTSLREINL-----------------------LISLRHPAIVDVREVVI----
CDK11_b-1_Smoe HEREGFPMTSLREINV-----------------------LLSFHHPSIVDVKEVVV----
CDK11_a-1_Smoe QETEGFPVTSLREINL-----------------------LISLRHPAIVDVREVVI----
CDK11_c_Smoe HERDGFPMTSRKSTFFSRFTIHRSWMSRKWWSHALQRNDQCSFNASSICTTTDQALLWNL
:* :***:** :. . . . * . : :
CDK11a_Hsap ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF
CDK11b_Hsap ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF
CDK11_Mmus ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF
CDK11_d_Smoe ---------------------------MPYKAM----TSALS------------------
CDK11_b-2_Smoe ---------------------------GSNLDS----IFMVMEYMEHDLKGLMDAMKQPF
CDK11_a-2_Smoe ---------------------------GKDMDS----VFMVMEYIERNLKDVMAALPQPW
CDK11_b-1_Smoe ---------------------------GSNLDS----IFMVMEYMEHDLKGLMDAMKQPF
CDK11_a-1_Smoe ---------------------------GKDMDS----VFMVMEYIERNLKDVMAALPQPW
CDK11_c_Smoe MTKKELGSLLPQALAEPMCRSGSDASAGRERDRGGVTRWRLLRLQRVDLEAKAGTGKKPT
:
CDK11a_Hsap LPGEVK--TLMIQL---LRGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR
CDK11b_Hsap LPGEVK--TLMIQL---LRGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR
CDK11_Mmus LPGEVK--TLMIQL---LSGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR
CDK11_d_Smoe ---------------------EYLH-----------------------------------
CDK11_b-2_Smoe TQSEAK--CLMLQL---FEGVKYLHDNW----VLHRDLKTSNLLLNNRGDLKICDFGLAR
CDK11_a-2_Smoe EHAVVK--HMMQQL---LDAVAYLHANW----VLHRDLKPSNILVS-GGELKICDFGMAR
CDK11_b-1_Smoe TQSEAK--CLMLQL---FEGVKYLHDNW----VLHRDLKTSNLLLNNRGDLKICDFGLAR
CDK11_a-1_Smoe EHAVVK--HMMQQL---LDAVAYLHANW----VLHRDLKPSNILVS-GGELKICDFGMAR
CDK11_c_Smoe PKQDKSNRAAQIQAPGDSRGAKGNRDPRDLRGRLCRILKRGRRIII-VGHLNISPYPIDS
:
CDK11a_Hsap EYGSPLKAYTPVVVTLWYRAPELLL--------------------------GAKE----Y
CDK11b_Hsap EYGSPLKAYTPVVVTQWYRAPELLL--------------------------GAKE----Y
CDK11_Mmus EYGSPLKAYTPVVVTLWYRAPELLL--------------------------GAKE----Y
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe QYGSPLKTYTRMVVTLWYRAPELLL--------------------------GSKK----Y
CDK11_a-2_Smoe RYDSPIKAYTHKVVTMWYRAPELLA--------------------------STQEEQYHY
CDK11_b-1_Smoe QYGSPLKTYTRMVVTLWYRAPELLL--------------------------GSKK----Y
CDK11_a-1_Smoe RYDSPIKAYTHKVVTMWYRAPELLA--------------------------STQEEQYHY
CDK11_c_Smoe --CDPGPKFDTDPSRQWFRSLLVSEGGAFSDSFRVFHPEIAEAYTCWSQASGAEE--FNY
CDK11a_Hsap STAVDMWSVGCIFGELLTQKP-----LFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPA
CDK11b_Hsap STAVDMWSVGCIFGELLTQKP-----LFPGNSEIDQINKVFKELGTPSEKIWPGYSELPV
CDK11_Mmus STAVDMWSVGCIFGELLTQKP-----LFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPA
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe NAAIDMWSLGCIMAEFLAKEP-----LFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPG
CDK11_a-2_Smoe TAAVDVWSLGCIMAELILNET-----LFQGTSEIDQLRRIKKMVWTAQL-EKPGF-----
CDK11_b-1_Smoe NAAIDMWSLGCIMAEFLAKEP-----LFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPG
CDK11_a-1_Smoe TAAVDVWSLGCIMAELILNET-----LFQGTSEIDQLRRIKKMVWTAQL-EKPGF-----
CDK11_c_Smoe GSRIDHVLI---------AGPCAGHCQCPDGSHENSSCDGFAECGTDMCDILLEFKRAK-
CDK11a_Hsap VKKMTFSEHPYNNLRKRF--------GALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEY
CDK11b_Hsap VKKMTFSEHPYNNLRKRF--------GALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEY
CDK11_Mmus VKKMTFSEYPYNNLRKRF--------GALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEY
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe VK-CNFVRQPYNRLREKFP-PVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEW
CDK11_a-2_Smoe ----IFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALAHPW
CDK11_b-1_Smoe VK-CNFVRQPYNRLREKFP-PVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEW
CDK11_a-1_Smoe ----IFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISANAALAHPW
CDK11_c_Smoe LDTLPRSRSCYSALKHYLP--------FHHMKLHNWLLDLCLSFALLRKVSVRNGQ-QET
CDK11a_Hsap FRETPLPIDPS-------------------------------------------------
CDK11b_Hsap FRETPLPIDPS-------------------------------------------------
CDK11_Mmus FRETPLPIDPS-------------------------------------------------
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe FDEVPLPKMKE-------------------------------------------------
CDK11_a-2_Smoe FQEPPLPTPPP-------------------------------------------------
CDK11_b-1_Smoe FDEVPLPKMKE-------------------------------------------------
CDK11_a-1_Smoe FQEPPLPTPPP-------------------------------------------------
CDK11_c_Smoe TEAVTKPIDRVLLSKHESSDKMSCTEVAVHGQSSSLTDEIQQSAESCDNNNCSEVAPCGE
CDK11a_Hsap ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE-------------
CDK11b_Hsap ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE-------------
CDK11_Mmus ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE-------------
CDK11_d_Smoe ------------------------------------------------------------
CDK11_b-2_Smoe ------LMPTFPVRSDQDRRLRRAMKSPDPLEEQRRRELRGE------------------
CDK11_a-2_Smoe ------PLPAPPLAATM-------------------------------------------
CDK11_b-1_Smoe ------LMPTFPVRSDQDRRLRRAMKSPDPLEEQRRRELRGE------------------
CDK11_a-1_Smoe ------PLPALPLAATM-------------------------------------------
CDK11_c_Smoe SAILMDMSDETPTESSQQSL-EKLAAGWERLKSLMSRNLLSCKGHGETCVVRTVKKAGPN
CDK11a_Hsap --TGFHLTTTNQGASAAGPGFSLKF
CDK11b_Hsap --TGFHLTTTNQGASAAGPGFSLKF
CDK11_Mmus --TGFHLTTTNQGASAAGPGFSLKF
CDK11_d_Smoe -----------------------DD
CDK11_b-2_Smoe ------------------FGAGVFG
CDK11_a-2_Smoe ----------------------PLQ
CDK11_b-1_Smoe ------------------FGAGVFG
CDK11_a-1_Smoe ----------------------PLQ
CDK11_c_Smoe LGRGFYVCTRAKGPAS---THKLGI