KHS2_Hsap MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE
KHS1_Hsap MEAPL------RPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE
HPK1_Hsap MDV---------VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME
GCK_Hsap MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD
KHS2_Mmus MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE
KHS1_Mmus MEAPL------RPAADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE
HPK1_Mmus MAL---------VDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKME
GCK_Mmus MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD
CG7097_Dmel MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLE
ZC404.9_Cele MSA-----------DVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLE
KHS_Spur MSQT--------PSAEISRKNPLEDFELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIE
AqueK230_Aque MAISP-----DGILPNISRKNPERDFELVKQIGSGTYGEVYKAKLVKTGQLCALKIIKIE
AqueK231_Aque MAST--------LLPEIQLKDPVQDFELLSQIGSGGYGVVYKAKTVSDGQLCALKIIKIK
* : :* ::*:.::*.* ** *:**: * *:*::*:.
KHS2_Hsap PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS
KHS1_Hsap PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS
HPK1_Hsap PDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS
GCK_Hsap PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE
KHS2_Mmus PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS
KHS1_Mmus PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS
HPK1_Mmus PDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS
GCK_Mmus PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE
CG7097_Dmel PSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLT
ZC404.9_Cele AGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTG-PLS
KHS_Spur PGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTG-HLA
AqueK230_Aque PGEDFNIIQQEILILSECKHANIVGYLGSYLRxxxxxxxxxxxxxxxxxxxxxxxx-xxx
AqueK231_Aque AGEDFNLIQKEISILSHCKHPNIVGYYSSYLRKDKLWISMEFCEAGSLYNMMHVQHSGLN
..::. :*:** :: * * *::.* .**:
KHS2_Hsap ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK
KHS1_Hsap ELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK
HPK1_Hsap ELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRL
GCK_Hsap ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR
KHS2_Mmus ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK
KHS1_Mmus EMQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK
HPK1_Mmus ELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRL
GCK_Mmus ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR
CG7097_Dmel EVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRK
ZC404.9_Cele ELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRK
KHS_Spur ELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRK
AqueK230_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
AqueK231_Aque ELQIAFVCKETLQGLTYLHERNILHRDIKSANILLTHDTVVKLADFGIATQLTQTMGKRK
KHS2_Hsap SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS
KHS1_Hsap SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS
HPK1_Hsap SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS
GCK_Hsap SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS
KHS2_Mmus SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS
KHS1_Mmus SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS
HPK1_Mmus SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS
GCK_Mmus SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS
CG7097_Dmel SFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKS
ZC404.9_Cele SFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKS
KHS_Spur SFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKS
AqueK230_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxALYLMTKR
AqueK231_Aque TFIGTPYWMAPEVAAVDKKGGYNQKCDIWSLGITAIELAEMQPPMNDLHPFRSVTIN---
: :
KHS2_Hsap NFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ-HPFVTQ---HLTRSLAIEL
KHS1_Hsap NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVAQP--GLSRALAVEL
HPK1_Hsap GYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLS-HQLVSQP--GLNRGLILDL
GCK_Hsap SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQ-HPFTTQ---QLPRALLTQL
KHS2_Mmus NFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPNAEKLLQ-HPFVTQ---PLTRSLAIEL
KHS1_Mmus NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVGQP--GLSRALAVEL
HPK1_Mmus GYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLS-HQLVSQP--GLNRGLILDL
GCK_Mmus SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQ-HPFTTQ---HLPPALLTQL
CG7097_Dmel GFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQ-HPFVQC---EMSLRVAKEL
ZC404.9_Cele GYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLG---SLSARMTRDL
KHS_Spur NFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQ-HPYFQDNIDRLTEQTMRQL
AqueK230_Aque NFRPPTLQHKNKWSNNFHDFLSQALKKDPKIRPNADDLLK-HEFVHR---DLSGLLMVPL
AqueK231_Aque -------------------------------------IL-WDDFVKR---DLSGLLMGPL
:* . : *
KHS2_Hsap LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIHSTSRNVREEKT--
KHS1_Hsap LDKVNNPDNHA-H-Y-----TEADDDDF----EPH----AIIRHTIRSTNRNARAERT--
HPK1_Hsap LDKLKNPGKGPS--I-----GDIEDEEP----ELP----PAIPRRIRSTHRSSSLGIP--
GCK_Hsap LDKASDPHLG--T-P------SPEDCEL----ETY----DMFPDTIHSRGQHGPAERT--
KHS2_Mmus LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIPSTSRNVREEKT--
KHS1_Mmus LDKVSNPDNHA-P-Y-----SEGDEDDL----EPH----AIIRHTIRSTNRNSRAERT--
HPK1_Mmus LDKMKNPGKGLP--------VDIEDEEP----EPP----PAIPRRIRSTYRASSLGIP--
GCK_Mmus LDKASDPHLG--T-L------SPEDSEL----ETH----DMFPDTIHSRSHHGPAERT--
CG7097_Dmel LQKYQSPNPQFY--------YYL-DGDE----ESV----AGVPQRIASKMTSRTNGVPAQ
ZC404.9_Cele LDKVNGAPTDVYD-RMSKTVDDLTEEESDMDDAPSLLTPDAAPIRIGLPAH---------
KHS_Spur LEKARNVNPGYSP-I-----EDDDDDRL----DEQAL--VNVKKRV-SSKRTDQKDRP--
AqueK230_Aque IRVLEAPSPKPKMSA-----SDPDEEDD----TGARK--ESQMKRISSVKHHNKIDRQ--
AqueK231_Aque MKAFEASST-AS--A-----P-PDDQSD----FEL----GQPRKRIASIARKKTAGQA--
: : :
KHS2_Hsap ------------------------RSEITFGQ-----VKFD--PPLR-------------
KHS1_Hsap ------------------------ASEINFDK-----LQFE--PPLR-------------
HPK1_Hsap ------------------------DADCCRRH-----MEFR--KLRG-------------
GCK_Hsap ------------------------PSEIQFHQ-----VKFG--APRR-------------
KHS2_Mmus ------------------------RSEINFGQ-----VKFD--PPLR-------------
KHS1_Mmus ------------------------ASEINFDK-----LQFE--PPLR-------------
HPK1_Mmus ------------------------DADCCRRQ-----MEFQ--RPRC-------------
GCK_Mmus ------------------------PSEIQFHQ-----VKFG--APRR-------------
CG7097_Dmel NHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSC
ZC404.9_Cele -----------------------------LNG-----LRL--------D-----------
KHS_Spur ------------------------ASEINMDF-----VKKV--K--E-------------
AqueK230_Aque ------------------------ISDVAMHG-----LNL---PPKQ-------------
AqueK231_Aque ------------------------STLATWLE-----VV---------------------
:
KHS2_Hsap ------------------------------------------------------------
KHS1_Hsap ------------------------------------------------------------
HPK1_Hsap ------------------------------------------------------------
GCK_Hsap ------------------------------------------------------------
KHS2_Mmus ------------------------------------------------------------
KHS1_Mmus ------------------------------------------------------------
HPK1_Mmus ------------------------------------------------------------
GCK_Mmus ------------------------------------------------------------
CG7097_Dmel SSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQH
ZC404.9_Cele ------------------------------------------------------------
KHS_Spur ------------------------------------------------------------
AqueK230_Aque ------------------------------------------------------------
AqueK231_Aque ------------------------------------------------------------
KHS2_Hsap --------KETEPHHELPDS-DGF-LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANK
KHS1_Hsap --------KETEARDEMGLSSDPN-FMLQ-------------------------------
HPK1_Hsap --------METRPPANTARLQPPR-DLR----S---------------------------
GCK_Hsap --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G
KHS2_Mmus --------KETEPHHELPDS-DGF-FDSSEEIYYTARSNLDLQLEYGQGHQSHCFLGGNK
KHS1_Mmus --------KETEARDEMGLSSEPN-FILH-------------------------------
HPK1_Mmus --------VDCRPQAETVRLYPPA-HFG----S---------------------------
GCK_Mmus --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G
CG7097_Dmel QSHQLPQQQQQQSHQAAQQE-HHHHHPMTSSISS-------------------------G
ZC404.9_Cele ----------ARCLEQ--------------------------------------------
KHS_Spur --------VPRMPPDDDGMLGEGN-YQGAHEW-----TPSNA------------------
AqueK230_Aque --------EAQEPISAWLDE-PFH-KPRIQRLS---------------------------
AqueK231_Aque ------------------------------------------------------------
KHS2_Hsap SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDE
KHS1_Hsap --------------------------------------------------W-NPFVDGAN
HPK1_Hsap ---------------S-SPR---------------------------KQLSESSDDDYDD
GCK_Hsap SLLQSVQEAL-EERSL-TIR---------------------------SASE-FQELDS--
KHS2_Mmus SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDD
KHS1_Mmus --------------------------------------------------W-NPFVDGAN
HPK1_Mmus ---------------T-SPR---------------------------SQLSD-SDDDYDD
GCK_Mmus SLLQSVQEAL-EERSL-TIR---------------------------PALE-LQELDS--
CG7097_Dmel -LVTANANNISSSASL-ASMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLR-TTSIDADD
ZC404.9_Cele -------------------------------------------------LSS-SPNTSSE
KHS_Spur -------ETE-GRKGH-Q-T---------------------------NDFK-GAEENTEE
AqueK230_Aque ------AEAI-TQYDMTDPE---------------------------YQSVDSIYQSPED
AqueK231_Aque -------------------------------------------------------AESN-
KHS2_Hsap SKHST----LKAKIPPPLPPK---------------------------------------
KHS1_Hsap TGKST----SKRAIPPPLPPK---------------------------------------
HPK1_Hsap VDIPT----PAEDTPPPLPPK---------------------------------------
GCK_Hsap ------------------------------------------------------------
KHS2_Mmus SKHST----MKAKVPPPLPPK---------------------------------------
KHS1_Mmus TGRST----SKRAIPPPLPPK---------------------------------------
HPK1_Mmus VDIPA----PSENIPPPLPPK---------------------------------------
GCK_Mmus ------------------------------------------------------------
CG7097_Dmel DELVA-ADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAAQASQAAH
ZC404.9_Cele SD---------RRTPT-ATPR---------------------------------------
KHS_Spur GKHDT-L--PHSDRPPPLPPK---------------------------------------
AqueK230_Aque SLTPPPA--DRTPVAPPVPPR---------------------------------------
AqueK231_Aque ------------------------------------------------------------
KHS2_Hsap PK-SIFIP-QEMH-----------------------------------------------
KHS1_Hsap PR-ISSYP-EDNF-----------------------------------------------
HPK1_Hsap PK-FRS-P-SDEG-----------------------------------------------
GCK_Hsap ------------------------------------------------------------
KHS2_Mmus PK-SIFIP-QDTH-----------------------------------------------
KHS1_Mmus PR-VNTYP-EDSL-----------------------------------------------
HPK1_Mmus PK-FRS-P-SDDG-----------------------------------------------
GCK_Mmus ------------------------------------------------------------
CG7097_Dmel PH-VNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISS
ZC404.9_Cele SLNRGYHS-ERTL----PA-----------------------------------------
KHS_Spur QK-SVKFS-ASNG-----------------------------------------------
AqueK230_Aque GT-SSS-R-ISRV-----------------------------------------------
AqueK231_Aque ------------------------------------------------------------
KHS2_Hsap --------------------------ST---EDEN--QGTIKRCPMSGSPA-KPSQ-VPP
KHS1_Hsap --------------------------P----DEEK--ASTIKHCPDSESR--APQI-LRR
HPK1_Hsap --------------------------PGSMGDDGQLSPGVLVRCASGPP----PNS-PRP
GCK_Hsap ---------------------------P---DD-T--MGTIKRAPFLGPLPTDPPA-EEP
KHS2_Mmus --------------------------SA---EDGN--QGTIKRCPSSGSPA-KPSH-VPP
KHS1_Mmus --------------------------P----DEEK--SSTIKRCPDLEAR--APQV-LRR
HPK1_Mmus --------------------------SGGIRDDGQLSPGVLVRCASGPP----PRT-PRP
GCK_Mmus ---------------------------P---DD-A--IGTIKRAPFLGLPHTESTSGDNA
CG7097_Dmel SGGASSGTNGLLDKHELDALPQAATKSA---GDGF--SHSNSPTANSGAGA-TGSR-DND
ZC404.9_Cele -----------------KEMP-------LLPDVVG--GDALLHCGNGVIHDDDETL-RAP
KHS_Spur --------------------------TA----S-N--ASTRESA--------PPSV-PPS
AqueK230_Aque --------------------------PIPLPDDN-NSPHVYGNVGPSNP-----------
AqueK231_Aque ----------------------------------------------------DRKG-IKP
KHS2_Hsap -RPPPP---------------RLPPHKPV-------------------------------
KHS1_Hsap -QSSPS---------------CGPVAETS-------------------------------
HPK1_Hsap -GPPPS---------------TSSPHLT--------------------------------
GCK_Hsap LSSPPG---------------TLPPPPS--------------------------------
KHS2_Mmus -RPPPP---------------RLPPQKPA-------------------------------
KHS1_Mmus -QSSPS---------------CVPVAETS-------------------------------
HPK1_Mmus -GPPPA---------------TCSPHLT--------------------------------
GCK_Mmus QSCSPG---------------TLSAPPA--------------------------------
CG7097_Dmel -GPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIG
ZC404.9_Cele -RAPPR---------------TLRAAQKA-------------------------------
KHS_Spur -KPNR------------------PQ---Q-------------------------------
AqueK230_Aque ------------------------------------------------------------
AqueK231_Aque TTSPPC---------------TSPVDTTL-------------------------------
KHS2_Hsap ------------ALGNGMSS---FQLNGER-DG-SLCQQQNEHRGTNLSRK----EKKDV
KHS1_Hsap ------------SIGNGDGI---SKLMSENTEG-SAQ------APQLPRKK----DKRDF
HPK1_Hsap ----------------AHSE---PSLWNPPSRE-LDK------PPLLPPKKEKM------
GCK_Hsap --------------------------------G-PNS------SPLLPTAWATMKQREDP
KHS2_Mmus ------------VLGNGVNS---FQLNGER-DG-SLYQQQSEQRGTNLSRK----EKKDV
KHS1_Mmus -----------SSIGNGDGI---SKLISENTEG-SAQ------APQLPRKK----DKRDF
HPK1_Mmus ----------------ARSD---PSLWNPAAPE-PGQ------PPLVPPRKEKMRGKMEN
GCK_Mmus --------------------------------G-PGS------PALLPTAWATLKQQEDR
CG7097_Dmel LLENMGKSPRTRSLSDGGTQ-DDDEAEKEAQPDLLNN------TPPVPPKRS-HKRRHTP
ZC404.9_Cele ------------AAGNSKNRFSSTSIA----------ST----------------PSEDG
KHS_Spur -----------QKMMNGRAP---T-TEGENTEDIDNK------PPIVPPRRIRNEFLEPP
AqueK230_Aque --------------------------------------------PVPPRNRP-PQETVTP
AqueK231_Aque -----------RSIANGGVA-----------------NGGV-------------------
KHS2_Hsap PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFG
KHS1_Hsap PKPAINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG
HPK1_Hsap ----------------------KRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLG
GCK_Hsap ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVG
KHS2_Mmus PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFG
KHS1_Mmus PKPTINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG
HPK1_Mmus ----------EK----------RREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLG
GCK_Mmus ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLQIHAAVTWVHPVTRDQFLVVG
CG7097_Dmel PRPISNGLPPTP----------KVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIG
ZC404.9_Cele -LTTFFGMPLIP----------KVPMGACFSKVMDRTELKINCAASWVHPLTGAHLLLFG
KHS_Spur PQQASNGLPPTP----------KVTMGACFSKVFNECPLVIHCSASWVHPETRDQYIIFG
AqueK230_Aque TNPTPPAVPPRPSSKPSIHKKQSTEGRAYFSKIFNGCPLKLHCATSWTHPHNQNYYVLLG
AqueK231_Aque ----------------------EERGRACFTKIFKGCPLQVHCAGSWIHPIREVLFVLLG
. : *::. * ::.: :* :* ::.*
KHS2_Hsap AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYAR
KHS1_Hsap TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAK
HPK1_Hsap AEEGIFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLERKE
GCK_Hsap AEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR
KHS2_Mmus AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVS-GKASQLYSHNLPGLFDYAR
KHS1_Mmus TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEQAK
HPK1_Mmus AEEGIFILNRND-QEATLEMIFPGRTTWLYCINNLLMSLS-GKTPYLYSHSILGLLERKD
GCK_Mmus AEEGIYTLNLHELHEDTMEKLISQRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR
CG7097_Dmel AEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLS-GKSCQLYRHDLVALHSKQT
ZC404.9_Cele TEQGIYSFDTNCMPDGNLSKIHHRRCSWMFVYADRLTAIQ-GNTPYVYRHDLVALTQKNL
KHS_Spur CDEGIYMFNLTQIHEGAMDQMFPRKTTWLYIINNIMMSLS-GKNPSIYQHNLVALVDKNP
AqueK230_Aque AEEGLFSLQANTQQDPVMEQVSPRSCHWLRVVENVLIWLS-GTNHMISMTNLIQLFQSES
AqueK231_Aque TQEGLFYLQVNREGDPIIEQVDSDH---MISM-----------------TNLILLFQNEQ
::*:: :: : :. : : .: * .
KHS2_Hsap QMQKLPV--AIPAHKLPDR-ILPRKFSVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL
KHS1_Hsap K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL
HPK1_Hsap TRAGNP-----IAHISPHR-LLARKNMVSTKIQDTKGCRACCVAEGA--SSGGPFLCGAL
GCK_Hsap LQQQVPL--SIPTNRLTQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGATFLLAAL
KHS2_Mmus QMQKLPV--AIPAHKLPDR-ILPRKFAVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL
KHS1_Mmus K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL
HPK1_Mmus GRTGSP-----IAHISPHR-LLARKNMVSSKIQDTKGCRACCVAESA--SSGGPFLCGAL
GCK_Mmus LQHQAPL--SIPTNRITQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGSTFLLAAL
CG7097_Dmel V----RF--SLHMNKIPER-LVPRKFALTTKVPDTKCCTQCCVTRNP--YNGYKYLCGAT
ZC404.9_Cele T---LKM--SKNLNKIPEK-YVPKRLAITVRMPETRGALQCTVKRGQGAQANSLFLCCAV
KHS_Spur HRFHMPSRFGEKLQRIPDK-LVPRKFALSHKVPDTKGCTKCCVVRNP--YNSHKYLCGAL
AqueK230_Aque QKA--PG---------------HRNRSHTSKIHDSKGCYKCSIARNP--FSDQRYLLAAV
AqueK231_Aque EIAARRG--GGGGGKDGETFRRNRRIRHSSKIKDSIGCFKCSIVVNP--YNKEKYLIAAV
:. : :: :: . * : . :* *
KHS2_Hsap QTSIVLLEWVEPMQKFMLIKHI--DFPIPC------------PLRMFEMLVV-PEQEYPL
KHS1_Hsap QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM
HPK1_Hsap ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLSVFALLTG-PGSELPA
GCK_Hsap PTSLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ
KHS2_Mmus QTSIVLLEWVEPMQKFMLIKHI--EFPMPC------------PLRMFEMLVV-PEQEYPL
KHS1_Mmus QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM
HPK1_Mmus ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLPVFTLLTT-PGSELPA
GCK_Mmus PASLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ
CG7097_Dmel PSGIFLMQWYDPLNKFMLLKQC--EWPAISIQGGGHGCVQNGHTPVFEMIIT-PELEYPI
ZC404.9_Cele RKTVHLFQWYNPMNQFVLVRSEPIREDIRF------------PIRPFALINS-RTSDFPE
KHS_Spur PAGVVLLQWYEPMNKFLQVKVF--DCPLPP------------EIKVFEMLIK-PDAEFPI
AqueK230_Aque PKGILVMQWYQPRHAFMHVKLF--ECSLPS------------PLNMFEAFVI-ENDEYPS
AqueK231_Aque PKGILLMQWYQISHAFMLVKLF--ECSLPS------------PLVLFEAFVLTQEDEYPT
: :::* : : *: :: : : : *
KHS2_Hsap VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DTPQTNVTHVTQLERD
KHS1_Hsap VCVAISKGTESNQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD
HPK1_Hsap VCIGVSPGRPGK-SVLFHTVRFGALSCWLGEM------------STEHRGPVQVTQVEED
GCK_Hsap VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD
KHS2_Mmus VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DAPQTSVTHVTQLERD
KHS1_Mmus VCVAISKGSDSSQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD
HPK1_Mmus VCIGVSPGQAAK-SVLFHTVRFGALSCWLDDS------------STEHKGPVQVIQVKED
GCK_Mmus VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD
CG7097_Dmel VCTGVRKAMN-G-CLKLELINMNSAS-WFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKD
ZC404.9_Cele LCIGVGQMSGSN-EYQFNMINFCSSTNN-SELSGDLNSSYGSLADDEMLEVGSMHQIDRD
KHS_Spur VCVGVARGLDRS-HLTFDVVNLNSTSSWFVEHP----------PTEKLLDVVCVSQIERD
AqueK230_Aque VCVGVRESEG-G-NVQFNAININSNSCWFDSF------------S--NDEIIELQQLEKD
AqueK231_Aque ICVGVNTSTG-D-NVLFNTISLNPSSSSITV--------------SHNSDITKLEQVEKD
:* . :. : . : *:..*
KHS2_Hsap TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
KHS1_Hsap TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG
HPK1_Hsap MVMVLMD----GSVKLVTPEGSPVR-GL-RTPEIPMTEAVEAVAMVGGQLQAFWKHGVQV
GCK_Hsap TILVSFE----RCVRIVNMQGEPT---ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQG
KHS2_Mmus TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
KHS1_Mmus TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG
HPK1_Mmus MVMVLMD----GSLKLVTPEGAPAP-GL-RTPEIPMTEAVEAVAMVEDRLEAFWKHGVQV
GCK_Mmus TVLVSFE----RCVRIVNLQGEPT---AALAPELTFDFTIETVVCLQDSVLAFWSHGMQG
CG7097_Dmel AILVCYG----NLIQVVTLQGNPKQ-HKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQG
ZC404.9_Cele TLCFSFR----NKVVLTDLQGFERP-K---PSIFTFNFHIEYLHVVDGTILAFHANGVQG
KHS_Spur TVLVCFD----SEVKVVNLNGRPRN-SKKLLTELHFDFAVDKLVVLQDSVLAFHRHGMQG
AqueK230_Aque TIFVASQ----FCAKFVDLNGTMKP-SGKQASQIYFDKKTESMVYLQNCVLSFHKHGMQG
AqueK231_Aque TILILDSRILTYCAKFVDISGSLKAPEEKMASSLYFDK--ESVM-----MGSFNDHGLQG
: . .. .* . : : : : : :* :*:*
KHS2_Hsap RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL
KHS1_Hsap KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPT-------------AHSNLYIL
HPK1_Hsap WALGSDQLLQELRDPTLTFRLLGSPRL---ECSGTISPHCNLLLPGSSNSPASASRVAG-
GCK_Hsap RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPE-------------AHSNLYIL
KHS2_Mmus RSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL
KHS1_Mmus KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPA-------------AHSNLYIL
HPK1_Mmus WAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDP-------------TAPSNLYI-
GCK_Mmus RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPG-------------AHSNLYIL
CG7097_Dmel KSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGS---------LGSEEGHDLYIL
ZC404.9_Cele RDLKSNLNTQDLCDVSRLYRVIGDDRVIILRSQPMSPR-----------NSGDTCDVSLL
KHS_Spur RSFRSNEVTQEICDKSKLFTLLGHEKLTVLKSHPLSDPT-------------APCNIYLL
AqueK230_Aque KSLITQQVTAEVADSSKVFHLLGSHGTIIIETKQADDAS-------------GPSNLYIL
AqueK231_Aque KSLLTEQVTAEVIDHSKKFKLLCSDGTIIVETKRADNPS-------------YPSSLYLL
:: * : : :: . :
KHS2_Hsap AG----HEN---SY
KHS1_Hsap AG----HEN---SY
HPK1_Hsap -------IT---GL
GCK_Hsap TG----HQS---TY
KHS2_Mmus AG----HEN---SY
KHS1_Mmus AG----HEN---SY
HPK1_Mmus ------------QE
GCK_Mmus TG----HQS---SY
CG7097_Dmel AG----HEA---SY
ZC404.9_Cele MG----HTDTPIAG
KHS_Spur TG----HAN---MM
AqueK230_Aque VSEEAYHVH---SQ
AqueK231_Aque ES----E-E---AT