mek-2_Cele lqtegelghgnggvvnkcvhrktgvimarklvhleikpsvrqqivkelav--lhkcnspf
Dsor1_Dmel LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKV--LHECNFPH
MAP2K1_Mmus FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY
MAP2K2_Mmus FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQV--LHECNSPY
MAP2K1_Hsap FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY
MAP2K2_Hsap FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY
MEK_Spur FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKV--LHECNSPY
CC1G_02205_Ccin LKKLSDLGQGNGGSVEKVEHLPTGTIMAKKSVLIDAKSSVRKQILRELDI--MHECQSDY
CC1G_03368_Ccin LVDIHDLGQGNGGSVKKVEHTPTKMIMAKKTVLIDAKPSVRKQILRELHI--MHDCRSDY
AqueK243_Aque FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKV--LHDCNASY
GK083_Glam LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQTQKNIYREIKASISLSCN-PY
: ** * * * : : * * : :. : :::* :*: .*. .
mek-2_Cele ivgfygafvdnndi-sicmeymdglsldivlkkv--grlpekfvgrisvavvrgltylkd
Dsor1_Dmel IVGFYGAFYSDGEI-SICMEYMDGGSLDLILKRA--GRIPESILGRITLAVLKGLSYLRD
MAP2K1_Mmus IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLRE
MAP2K2_Mmus IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKEA--KRIPEDILGKVSIAVLRGLAYLRE
MAP2K1_Hsap IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLRE
MAP2K2_Hsap IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKEA--KRIPEEILGKVSIAVLRGLAYLRE
MEK_Spur IVGFFGAYYSDGEI-CICMENMDGGSLDQVMKSAPKGRIPENILGKVTVAVLRGLIYLRD
CC1G_02205_Ccin IISCFGSFLAEPNI-CICMEFMDKGSFDGIYKKL--GPLQVEVVGMVALSVLEGLTYLYD
CC1G_03368_Ccin IISFYGAFLADNNI-CICMEFMDKGSLDGIYKKI--GAIDIDIVGKIALAVLEGLTYLYD
AqueK243_Aque IVGFFGSFHVNNEI-SILMQHMDGGSLDLVLN-T--GRIPVDMIGQITVAVLNGLKYLRD
GK083_Glam MVKTYNIYSHPGSILHILLEFCKYGSSQDMLKKLKTGKLTENALAVFIIDTLRGLAYLHD
:: :. : .* * :: . * : : : : . :. . : .:.** ** :
mek-2_Cele eikilhrdvkpsnmlvnsngeiklcdfgvsgmlid----smansfvgtrsymaperlt--
Dsor1_Dmel NHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLID----SMANSFVGTRSYMSPERLQ--
MAP2K1_Mmus KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--
MAP2K2_Mmus KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--
MAP2K1_Hsap KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--
MAP2K2_Hsap KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMAPERLQ--
MEK_Spur VHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--
CC1G_02205_Ccin VHRIMHRDIKPSNILFNSQGQIKLCDFGVSGEVIN----SIANTFVGTSVYMSPERIQSH
CC1G_03368_Ccin VHRIIHRDIKPSNILCNSRGQIKICDFGVSGELIN----SIADTFVGTSTYMSPERIQ--
AqueK243_Aque THHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLIN----SMANSFVGTRSYMAPERLQ--
GK083_Glam NCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQ--
*:***:*.:*:* :. * *:.****:. :: : .:***: **:***:
mek-2_Cele gshytissdiwsfglslvelligrypvpapsqaeyatmfnvaen---eieladslee---
Dsor1_Dmel GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEES--GQ----------
MAP2K1_Mmus GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHV----EGDAAETPPR---
MAP2K2_Mmus GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPR---
MAP2K1_Hsap GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPR---
MAP2K2_Hsap GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPR---
MEK_Spur GTHYTVQSDIWSLGLSLVEMAIGRYPIPAPDETALANLFGYELQA---GETKN-IRK---
CC1G_02205_Ccin GDGYSVKSDVWSLGMSLVELALGAFPFTDPPDDDDDDL-SDLEG--DS---SSPSPSDAQ
CC1G_03368_Ccin GAQYTVKSDVWSLGISLIELALGRFPFSQSDSDESDDEFSDASD--YEGT-LSPQPAGSV
AqueK243_Aque GEVYSVLSDIWSLGVSLIEMAIGSYPIPAPPKEQLDEEMRNPP----AG----SL-P---
GK083_Glam NQPYSYVSDVWSMGLTYVELLTGSYPYDNV------------------------------
. *: **:**:*:: :*: * :*
mek-2_Cele --pn-----------------------yh-p---psnpasmaifemldyivngppptl-p
Dsor1_Dmel ---------------------------------PTDEPRAMAIFELLDYIVNEPPPKL-E
MAP2K1_Mmus --PR------------------TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-P
MAP2K2_Mmus --PR------------------PPGRPISVGH-GMDSRPAMAIFELLDYIVNEPPPKL-P
MAP2K1_Hsap --PR------------------TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-P
MAP2K2_Hsap --PR------------------PPGRPVS-GH-GMDSRPAMAIFELLDYIVNEPPPKL-P
MEK_Spur --TR-----------------------VG-GV-FSDSPRPMAIFELLNYIVEEHPPRL-P
CC1G_02205_Ccin -HQRTPTHRDSFLLSKKTAKRASKRRSKL-TYNPDGQLSTMSIFELIHQIVQEPSPRL-P
CC1G_03368_Ccin SLADLP--------------PPKPRRQKN-AN-GNGSTTKKDKRKSKGHIVNEPAPRLTP
AqueK243_Aque --PR--------------------RNPYA-S---HANAIRMPVFELLQMIFTDDPPRL-P
GK083_Glam ----------------------------------------NSFWDAMNVIVNGAPPLL-K
. *. .* *
mek-2_Cele k-rfftdevigfvskclrklpseratlkslt--advff
Dsor1_Dmel H-KIFSTEFKDFVDICLKKQPDERADLKTLL--SHPWI
MAP2K1_Mmus S-GVFSLEFQDFVNKCLIKNPAERADLKQLM--VHAFI
MAP2K2_Mmus S-GVFSSDFQEFVNKCLIKNPAERADLKLLM--NHAFI
MAP2K1_Hsap S-GVFSLEFQDFVNKCLIKNPAERADLKQLM--VHAFI
MAP2K2_Hsap N-GVFTPDFQEFVNKCLIKNPAERADLKMLT--NHTFI
MEK_Spur S-RAFSEEFVDFVDVCLIKNPNERADLKKLK--VHTFA
CC1G_02205_Ccin S-DKFPADAVDLVDICLLKNPEERQTPKALLVRNHPWI
CC1G_03368_Ccin E-GRYPKAAESFIDACLLKDPDARQTPKDLL--KHEWI
AqueK243_Aque D-EYFDDKFKSFVALCLQKDVKKRGTLSALL--EHKFV
GK083_Glam EDAGYSPGLCDLVNAMLEKDPSKRMTAAQLL--KLPFC
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