jkk-1_Cele      MENVCFQ---QRLRDLETRVRKW-----K--FLKLG--------LTEVRLRPRDRRSTS-
mek-1_Cele      MERD------------------------------FD--------LGMGRPGG--------
hep_Dmel        MSTIEFETIGSRLQSLEAKLQAQNE-SHDQIVLSGARGPVVSGSVPSARVPPL-ATSASA
MAP2K7_Mmus     MAASSLE---QKLSRLEAKLKQENREARRRIDLNLD--------ISPQRPRPIIVITLSP
MAP2K7_Hsap     MAASSLE---QKLSRLEAKLKQENREARRRIDLNLD--------ISPQRPRPIIVITLSP
MKK7_Spur       MNRR---------------------------DQRFY--------IAFCR----------P
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      ---------------------------------VDQKHKECSSTSSSPQHQ---------
mek-1_Cele      ------------------------------------------------------------
hep_Dmel        ATSATHAPSLGAGSVSGSGISIAQRPAPPVPHA-TPFGSASASSSSSSASAFASAAPATG
MAP2K7_Mmus     APA------------------PSQRAALQLPLA-NDGGSRSPSSESSPQHP---------
MAP2K7_Hsap     APA------------------PSQRAALQLPLA-NDGGSRSPSSESSPQHP---------
MKK7_Spur       APR------------------YGQRGLPTLPLQLNHNGGLSPHAR---------------
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      ------RPN----N-------------IGYLTSPMERKFTPLSMKPSP-SRRDTEKDALE
mek-1_Cele      ---------------------------LGGLGGEPIMQQMPQPAPHH--PSRSSNDHNVK
hep_Dmel        TFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRP-VILPLPTPP------HPPVSETD
MAP2K7_Mmus     ------TPP------------------------TRPRHMLGLPST--LFTPRSMESIEID
MAP2K7_Hsap     ------TPP------------------------ARPRHMLGLPST--LFTPRSMESIEID
MKK7_Spur       ----------------------------------RDKKQVQMPLTCGPINRSTIDGPEID
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      YEFLEGYKKSGTLEIDGE------------------------------------------
mek-1_Cele      NLMKQAEENSGYLTLQGN------------------------------------------
hep_Dmel        MKLKIIMEQTGKLNINGR------------------------------------------
MAP2K7_Mmus     QKLQEIMKQTGYLTIGGQ------------------------------------------
MAP2K7_Hsap     QKLQEIMKQTGYLTIGGQ------------------------------------------
MKK7_Spur       RKLQEIMKQTGLLTTEGKRSTTLPVPKGAWFGCHADVSDRTCQNSLSSGRVLTLASQRLP
AqueK248_Aque   -----------------Q------------------------------------------
                                 .

jkk-1_Cele      ------------------------------------------------------------
mek-1_Cele      ------------------------------------------------------------
hep_Dmel        ------------------------------------------------------------
MAP2K7_Mmus     ------------------------------------------------------------
MAP2K7_Hsap     ------------------------------------------------------------
MKK7_Spur       ELCLRVALAILNAAGDRPIIRARHSSRGLKALKSTSFRGLRTLLPPVGALPLDPIRFRLG
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      ------------KQVVDPNEIHIISLLGSGSCGVVESATVR--SKLMAVKTMY-KNDNKE
mek-1_Cele      ------------RRKADLKELQFVEDIGHGSCGTVTKCRYK--SVIMAVKTMP-RTSNSY
hep_Dmel        ------------QYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMR-RTGNAE
MAP2K7_Mmus     ------------RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMR-RSGNKE
MAP2K7_Hsap     ------------RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMR-RSGNKE
MKK7_Spur       RYAPSQHSQTYRRYHINVESLESIGELGFGSCGHVIRMRHKESGTILAVKQMR-RSGNKE
AqueK248_Aque   ------------TYPFSMEDMLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWE
                                . :.:  :  :* * .* *        .  :*.* *  : ..

jkk-1_Cele      NLKRILRDVRIM-SMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFF
mek-1_Cele      EMSRILMDLDVICLSFDCPYIVRCFGYFITNFDVRVCMECMATCLDRLLIRIKQ----PI
hep_Dmel        ENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKK----PV
MAP2K7_Mmus     ENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQG----PI
MAP2K7_Hsap     ENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQG----PI
MKK7_Spur       ENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIKKLRE----PV
AqueK248_Aque   EQRRVLMDLEVM-NSQHSPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKRLKG----PI
                :  *:* *: ::    .. :**   *  :   .* : *: *. * ::*           .

jkk-1_Cele      PEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAH
mek-1_Cele      PERIIGKLSVSIIKALHYLKTKHQIMHRDVKPSNILLDWSGVIKLCDFGIAGRLIESRAH
hep_Dmel        PEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKAN
MAP2K7_Mmus     PERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK
MAP2K7_Hsap     PERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK
MKK7_Spur       PEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKAR
AqueK248_Aque   PERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAF
                ** : *::  : :.** ***  * ::***:****:*:*  * :*******:* : :* *

jkk-1_Cele      SKSAGCPPYMAPERLTIET--NSKYDVRSDVWSLGITV-------YQLVTGLYPFPLN--
mek-1_Cele      SKQAGCPLYMGPERLDPNN--FDSYDIRSDVWSFGVTL-------VELATGQYPYAG---
hep_Dmel        TRSAGCAAYMAPERIDP---KKPKYDIRADVWSLGITL-------VELATARSPYEGC--
MAP2K7_Mmus     TRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLQCLSPSQVELATGQFPYKNC--
MAP2K7_Hsap     TRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNC--
MKK7_Spur       TRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISL-------VTISFASY-------
AqueK248_Aque   TRGAGAAAYMAPERINMSHD-SKGYDVRADVWSLGISL-------VEMATGSAPYKFNEF
                :: **.. **.***:         **:*:****:*:::         :  .

jkk-1_Cele      DMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYL
mek-1_Cele      -TEFDMMSKILN--DEPPRLDP---AKFSPDFCQLVESCLQRDPTMRPNYDMLLQHPFVV
hep_Dmel        NTDFEVLTKVLD--SEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIR
MAP2K7_Mmus     KTDFEVLTKVLQ--EEPPLLPGH--MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK
MAP2K7_Hsap     KTDFEVLTKVLQ--EEPPLLPGH--MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK
MKK7_Spur       ------------------------------------------------------------
AqueK248_Aque   SSEFDLLTHIVQ--APPPLLDE---DKFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLIK


jkk-1_Cele      DYDPASGSAYKFKAINGKCNQVADWFVDVIRLSKTE--DELKS-----------------
mek-1_Cele      HHEKIE-------------TDVEEWFADVMGDDSAYHNSNEISNLTDQYAQSLQQQIQLL
hep_Dmel        IYESAK-------------VDVPNWFQSIK--DNRLRANGDPT-----------------
MAP2K7_Mmus     HYEILE-------------VDVASWFKDVMAKTESPRTSGVLS-----------------
MAP2K7_Hsap     RYETLE-------------VDVASWFKDVMAKTESPRTSGVLS-----------------
MKK7_Spur       -----------------------------IT-----------------------------
AqueK248_Aque   EYEEKP-------------VDVGEWFSEMCSTH---------------------------


jkk-1_Cele      ------------------------------------------------------------
mek-1_Cele      QIENAFLKEQQVKREENEQERIRNIEMEEQYRADKFRQEQQAKEFEDLQHRRESVSQINQ
hep_Dmel        ------------------------------------------------------------
MAP2K7_Mmus     ------------------------------------------------------------
MAP2K7_Hsap     ------------------------------------------------------------
MKK7_Spur       ------------------------------------------------------------
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      ---------------------------IPNT-----------------------------
mek-1_Cele      SRRGTTTQILARGNEVSINGETWCQLPPHHPPIPAIISDRSQYSQRIGRDRVSRLIIGFC
hep_Dmel        ---------------------------LQRL-----------------------------
MAP2K7_Mmus     ---------------------------QHHL-----------------------------
MAP2K7_Hsap     ---------------------------QPHL-----------------------------
MKK7_Spur       ------------------------------I-----------------------------
AqueK248_Aque   ------------------------------------------------------------


jkk-1_Cele      --------PCVN
mek-1_Cele      SKTKLIKCKNRR
hep_Dmel        --------P-NS
MAP2K7_Mmus     --------PFFR
MAP2K7_Hsap     --------PFFR
MKK7_Spur       --------REAY
AqueK248_Aque   ---------GIP