MAP3K2_Mmus MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K
MAP3K3_Mmus MDEQEALDSIMKDLVALQMSRRTRLSGY---------------------------ETM-K
MAP3K2_Hsap MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K
MAP3K3_Hsap MDEQEALNSIMNDLVALQMNRRHRMPGY---------------------------ETM-K
MEKK2_Spur MRFQRALEIITLTLAPAAVSAHSAFQGIILPVDPAADSNQVISEITDNLISLRVQGNRNR
AqueK227_Aque MADGQLPSIEAGDR----------------------------------------------
* . .
MAP3K2_Mmus AKPS-SPKK-------------------------------QNDVRVKFEHRGEKRILQVT
MAP3K3_Mmus NKDTGHPNR-------------------------------QSDVRIKFEHNGERRIIAFS
MAP3K2_Hsap AKSS-SPKK-------------------------------QNDVRVKFEHRGEKRILQFP
MAP3K3_Hsap NKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFS
MEKK2_Spur GRGS-SSSH-------------------------------STEIRVKFEFNGEKRILQIP
AqueK227_Aque ------------------------------------------SVRRRVDEDIHRHLIAGF
.:* :.: .::::
MAP3K2_Mmus RPVKLEDLRSKSKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK
MAP3K3_Mmus RPVRYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR
MAP3K2_Hsap RPVKLEDLRSKAKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK
MAP3K3_Hsap RPVKYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR
MEKK2_Spur RPLKYDDILLKARTTFGQPVDMFLTNHNTTFSLLIPIRDQTDLNHAVEITDNNPNAKSLR
AqueK227_Aque HPIDPV-------GGGGHNMKPPSLGHT---RTISGLSTQNELDFALSIYERFTGITSLR
:*: *: :. .: : * :*: *:.: :. .**:
MAP3K2_Mmus ILLVVNGS-----------TQA-TNLEPSPSP--------------------EDLNNTP-
MAP3K3_Mmus ILLLSQDRNHTSSSPHSGVSRQ-VRIKPSQSA--------------------GDINTIY-
MAP3K2_Hsap ILLVINGS-----------TQA-TNLEPLPSL--------------------EDLDNTV-
MAP3K3_Hsap ILLLSQDRNHNSSSPHSGVSRQ-VRIKASQSA--------------------GDINTIY-
MEKK2_Spur LHLELATPGSSSN--NNGSSKRDLYDTAIRSSSTIPQSKHTSPSRSQSVPQDHHVHTSH-
AqueK227_Aque VVLSRQPVTITAP--PT-----DVLSSASPTPDNLKEQVAKFTQRSQSEPYFMR-NTTEG
: * . : ..
MAP3K2_Mmus --LGAE----RKKRLSVV--GPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPE
MAP3K3_Mmus --QAPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE
MAP3K2_Hsap --FGAE----RKKRLSII--GPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPE
MAP3K3_Hsap --QPPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE
MEKK2_Spur --DT------THKRYSTQEMPTRDNANPSPPPGYVPANAMVDMGHQSRLQTFGEGTFIPE
AqueK227_Aque FRESPDMYFHTYHGFRNI--PEEPSRRDSPPPGFIDEPSTPVPLD---IGGKEGGKFIPE
. *****:: . * ****
MAP3K2_Mmus SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFTDY
MAP3K3_Mmus TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSQMSRARSFPDNRKECSDR
MAP3K2_Hsap SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFSDY
MAP3K3_Hsap TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSRMSRAQSFPDNRQEYSDR
MEKK2_Spur PPEERIM--V-------SPNGSQQSLDKLRMGSHSLGSA-TGKMFKSQSCA-NHDDFEN-
AqueK227_Aque VEDD-DLDNASPAS-------IPSTLDMSFISEENLSITGVDGLLR-------HHEYSLY
:: : :** . . . : : :.:
MAP3K2_Mmus DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSFR-SPVSFSPTDHSL
MAP3K3_Mmus ETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPR-IRRHQGNLF-----TLVPSSRSL
MAP3K2_Hsap DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSLR-SPVSFSPTDHSL
MAP3K3_Hsap ETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPR-IRRHQGNLF-----TLVPSSRSL
MEKK2_Spur -SQVGRGMIKGGTFPSRQSVKPSRIDTEDGRKTFPSRGKRPPLASMHDDQHSISDSLSSL
AqueK227_Aque DDKEHGAESLTRTYPREKSYSMGELPSHTHKAM--------YGT---Y-PLNPPPKLHPP
*:* . . . : . . .
MAP3K2_Mmus STSSGSSVFTPEYD-DSRIRRRGSDIDNPTLT-----VTDISPPSRSPRAPTNWRLGKLL
MAP3K3_Mmus STNGENMGVAVQYL-DPRGRLRSADSEN-ALT-----VQERNVPTKSPSAPINWRRGKLL
MAP3K2_Hsap STSSGSSIFTPEYD-DSRIRRRGSDIDNPTLT-----VMDISPPSRSPRAPTNWRLGKLL
MAP3K3_Hsap STNGENMGLAVQYL-DPRGRLRSADSEN-ALS-----VQERNVPTKSPSAPINWRRGKLL
MEKK2_Spur GRSS-SSGISPDYDTDSSIPRRWTEGDLEGLAGGHPKSFNLADNTRSPRAPTNWQRGKLL
AqueK227_Aque LSSHYHHKMVPGSS-DSR---RLQDSELPIQK-----LASLT-VSHKITAPARWSKGRLL
. . *. * : : . ::. ** .* *:**
MAP3K2_Mmus GQGAFGRVYLCYDVDTGRELAVKQVQFN--------PESPETSKEVNALECEIQLLKNLL
MAP3K3_Mmus GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ
MAP3K2_Hsap GQGAFGRVYLCYDVDTGRELAVKQVQFD--------PDSPETSKEVNALECEIQLLKNLL
MAP3K3_Hsap GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ
MEKK2_Spur GQGAFGVVYVCYDADTGRELAVKQVPTE--------NSNTDARKEVQSLKQEIELLRNLQ
AqueK227_Aque GTGAFGQVFLCTDLDTQMDMAVKVVDIDHIENIKPSLDSLKMSKEVRSFETEVQLLKNIH
* **** *::* * ** ::* * * : .. . *** ::: *::**:*:
MAP3K2_Mmus HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL
MAP3K3_Mmus HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
MAP3K2_Hsap HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL
MAP3K3_Hsap HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
MEKK2_Spur HPRIVQYFGCLEE--NGTLSIFMEFMSGGSVKDELRLYGPLTDTVTRKYTRQILEGTAYL
AqueK227_Aque HERVVGYYGTER--REGKLFIFMEYLAGGSIYQHLKNTGALSEALTRKYTRQILEGVAFL
* *:* *:* . : * ****::.***: :.*: *.*:: :*********** :*
MAP3K2_Mmus HSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS
MAP3K3_Mmus HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVIS
MAP3K2_Hsap HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS
MAP3K3_Hsap HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
MEKK2_Spur HDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIIN
AqueK227_Aque HGMKIVHRDIKGANILRDSNGNVKLADFGASKRLQTIR---SGIGSVHGTPYWMAPEVIK
*. **********:** * **:**.*****.***** :*: :* ******:**:*.
MAP3K2_Mmus GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF
MAP3K3_Mmus GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF
MAP3K2_Hsap GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF
MAP3K3_Hsap GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF
MEKK2_Spur GE-GYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNF
AqueK227_Aque GDDPYTFKADIWSVGATVVEMLKCRPPWSDFEPTAAMFKIVMNDTKPDLPPHCSEQAHNF
*: * :**:**:..******. :***:::*. **:***. : *:* ** *: ::*
MAP3K2_Mmus LKRIFVEA-KLRPSAEELLRHMFVH---YH
MAP3K3_Mmus LRRIFVEA-RQRPSAEELLTHHFAQL--VY
MAP3K2_Hsap LKRIFVEA-KLRPSADELLRHMFVH---YH
MAP3K3_Hsap LRRIFVEA-RQRPSAEELLTHHFAQL--MY
MEKK2_Spur LTLCFKKILADRPSAAELLRHNFVRTAPMD
AqueK227_Aque IELCFIKDKNERPSAMDLLSHSFCSVFPNT
: * : **** :** * *