B0414.7_Cele MSSNQYKRIKRC--KSMPTIDDETVG----------------------------------
Mekk1_Dmel MSNRRRVR----------TIDYLALQQS-LRLQKTPAATTNAEEQVAREEENGNGHHSTV
MAP3K4_Mmus MRDAIAEP-----------V------PP-PALADTPAAAM--------------------
MAP3K4_Hsap MREAAAAL-----------V------PP-PAFAVTPAAAM--------------------
MEKK4_Spur T-----------------------------------------------------------
AqueK228_Aque MAEGEGEEESYFPDHVVEGIDEEASGETDDKLSSLPVDSTSEEE----EEESG-------
B0414.7_Cele -------------------------------------EAVR----------K--------
Mekk1_Dmel TAETPPTPPIPPIPPIRLRREQSVEE-DVARVEYRVKQTPSRPVQMTRNRIGALEEDLPP
MAP3K4_Mmus -EELRPAPPPQPE-P-------DPECCPAARQECMLGESAR----------KSMESDPED
MAP3K4_Hsap -EEPPPPPPPPPP-PPEPETESEPECCLAARQEGTLGDSAC----------KSPESDLED
MEKK4_Spur ------------------------------------------------------------
AqueK228_Aque ------------------------------------------------------------
B0414.7_Cele -----------------------------------------T------------------
Mekk1_Dmel EDELAAHYEAFGTTPPRTRLKIKNRDWER-KQKVVNVTASADL------------PASVG
MAP3K4_Mmus FSDETNTETLYGTSPPSTPRQMKRLSAKH-QRNSAGR------------------PASRS
MAP3K4_Hsap FSDETNTENLYGTSPPSTPRQMKRMSTKH-QRNNVGR------------------PASRS
MEKK4_Spur -----------------TPTQQQQLVRLR-QKNSLNR------------------VVTRN
AqueK228_Aque ----SYDEGLTGSTPPSNSRL-HKMSRRGHKYKTSRKIMSSSSENQSPYRVKDITRAKSA
B0414.7_Cele IMKKVATRMNTSK-RE----Y---MGRRSLGVAT---VS---TKIKRKKSKTERDRDMYD
Mekk1_Dmel GTPKKTRTARSRV-LRRNTMDCALLNE--MFVNDESK--RTDKRLQSLLRDSEREMKNSL
MAP3K4_Mmus NLKEKMNTPSQSP-HKD-------LGKGVETVEEYSY--KQEKKIRATLRTTERDHKKNA
MAP3K4_Hsap NLKEKMNAPNQPP-HKD-------TGKTVENVEEYSY--KQEKKIRAALRTTERDRKKNV
MEKK4_Spur SLKMEMEALIQKI-IQEIIQDLMNFGQSAQNTKQKLH--QRKMRSIHLDRTSEREFKQKA
AqueK228_Aque DWSESVSTPSDSLIHK----RYSLTGEGEEISSELCQVSLCDKKRKEKSRQMERNVKSAI
. .. : **: .
B0414.7_Cele DMYDDEGYAASPTSSSSCTYRCIPILERSNRNSQNYLPSAESSSSDSNDRVISHPNHRPI
Mekk1_Dmel --ATTA-VAA--PRGNS-------------------FHETAHPLESLDQ-IMPLNS-EAM
MAP3K4_Mmus --QCSF-MLD--SVAGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK
MAP3K4_Hsap --QCSF-MLD--SVGGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK
MEKK4_Spur --I---------TYDGS-------------------ELHVPLTPTHVFRPFDSLPSPNLK
AqueK228_Aque --NHPE-MST--SPSSTANYTN----------TEPPRPSFSSPS-PSNPPYPVLAHSHSS
. .: . .
B0414.7_Cele LLY---------------------------------------------------------
Mekk1_Dmel API---P------LR----------------IA--SKVVESCNRYRCVSSRPIGYR----
MAP3K4_Mmus LPV---------------------------------------------------------
MAP3K4_Hsap LPV---------------------------------------------------------
MEKK4_Spur ID----------------------------------------------------------
AqueK228_Aque PPPSSHPPPSHPPSHPPPSHSPLPPPSSPPALPPPSPSHPPPPSYSPSSPSPLSYNVPPP
B0414.7_Cele -STALS------------------------------------------------------
Mekk1_Dmel -SSAPP------------------------------------------------------
MAP3K4_Mmus -SMPMP------------------------------------------------------
MAP3K4_Hsap -SVPMP------------------------------------------------------
MEKK4_Spur ------------------------------------------------------------
AqueK228_Aque SSYPLPPPNQSPSVDTSLYPPPIDPHYLPTGDSPVLYPLPHLSPETYSSKLSSSPYPSKL
B0414.7_Cele ---------------------------------------MA---------P-QQNLSVES
Mekk1_Dmel ---------------------------------------LA---------F-AAQLPAGM
MAP3K4_Mmus ---------------------------------------IA---------R---------
MAP3K4_Hsap ---------------------------------------IA---------R---------
MEKK4_Spur ------------------------------------------------------------
AqueK228_Aque GKVGSPNPMLSPGIPSHMRPSFSYTTDNIIPYYSLSSLSHAPPGVSIERSQSDAQLSLTL
B0414.7_Cele -LSDALDELEGADRSKLHMEITQFLK------KADGEKS-------KQIQMSQRLMNCPQ
Mekk1_Dmel LRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDA-KLS-------QEE---HTW-----
MAP3K4_Mmus TARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTAAFW-----
MAP3K4_Hsap PARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTSGFW-----
MEKK4_Spur ----------SSERVDFHRTFSALIRMGSAKKENSQEITQRIRR--QDGMTQDVF-----
AqueK228_Aque SSSSSHSMHCPPDRKQFYRNFSKRLKMIAKRQQQSSTQPGHIPRQHSEDLNAKNP-----
.* .:. : :: : :
B0414.7_Cele FGQTMRLIVEESEHTRYTFENILWLILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARKQ
Mekk1_Dmel ---------------QTELKDLIWLELQAWQADRTVE-----------QQDKYLFEARQG
MAP3K4_Mmus ---------------FNRSNELIWLELQAWHAGRTIN-----------DQDLFLYTARQA
MAP3K4_Hsap ---------------LNRSNELIWLELQAWHAGRTIN-----------DQDFFLYTARQA
MEKK4_Spur ---------------QMQWNEILWLELTAYHNELSIT-----------DQDLHLINARKK
AqueK228_Aque ---------------FGPDNEQLRMELRAYLNNHTLE-----------DQEEADYQLQCE
:: : : * :: : :: :
B0414.7_Cele YMMVMDMIKEFKFEVGKND---KD--D---------------------------------
Mekk1_Dmel VSDLLTHIINYKFQPRYRREPSLISLDSGTH-----------------------------
MAP3K4_Mmus IPDIINEILTFKVNYGSIA---FSSNGAGFN-----------------------------
MAP3K4_Hsap IPDIINEILTFKVDYGSFA---FVRDRAGFN-----------------------------
MEKK4_Spur VAEVFDEIMKFKYQSGRSS----SSSGSSSH-----------------------------
AqueK228_Aque SGSILYRIIHYSFSSDSTLSGY-FR-GLSESAKSLPAQLNELKRGSLRRRKMMPLQENKE
:: * :. .
B0414.7_Cele ----------------SPFESLN-----------------------RR------------
Mekk1_Dmel --------SDSNSNA-----S-------------------SPLPSKM-------CQGC--
MAP3K4_Mmus --------GPLVE------------------------GQCRTPQETN-------RVG---
MAP3K4_Hsap --------GTSVE------------------------GQCKATPGTK-------IVG---
MEKK4_Spur --------GDSVETS-----QMN---------GNACDTCCNPNPVQRRHPSVSDNGFCMP
AqueK228_Aque EEEEVEEKGEEEEGDETPLTSINNPSVRWEDGGGETEGEDEYGPQTL-IQQESNDSDALS
B0414.7_Cele M-EFSP-DYCENLRDARKRVSDVLDKYETLVDLFPNQNALWKVVELDRGEAEKKLLEGRM
Mekk1_Dmel -MSLYCKDCMDHQKLALREVEGMLTRLEAAEALYPSSQAMGALH----PIYKSQSFVGRI
MAP3K4_Mmus -CSSY-HEHLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDY----ERYAAKDFEDRV
MAP3K4_Hsap -YSTH-HEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDY----EKYAAKDFQDRV
MEKK4_Spur LSAAL-NAYITDTSEAWYKVHALLEDLEKVQLLYPNSKALQNDC----VELSTPEFTKRL
AqueK228_Aque VEFSFDNFLSEEQLQAIEDVDSLLSDLERVELLYASSKRVVD------KQYQQLPFKRRR
: * :: * *:.. : : : *
B0414.7_Cele TSMRVWLNTLDDLTDKFKALGVLFEIETMPDAE---------------------------
Mekk1_Dmel KSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSA----SGVEN
MAP3K4_Mmus QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPE----DEVED
MAP3K4_Hsap QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPE----YEGDD
MEKK4_Spur ETLCLWMNITNDISHKFELTSQILGVVDLEGLWWPYLDLPGYCVENPFQSESCIESEMDD
AqueK228_Aque AALVLWLKITEGLAKHLVNLSKWFGVIVNP------------------------VRRSED
:: :* : . :: . :
B0414.7_Cele -EC---------------------------------------------------------
Mekk1_Dmel DDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQ-W
MAP3K4_Mmus TEVELRELESGTEESDEEPT------PSPRV----------PE----LRLSTDAILDS-R
MAP3K4_Hsap TEGELKELESSTDESEEEQI------SDPRV----------PE----IRQPIDNSFDI-Q
MEKK4_Spur EVKPMNEFDDSTPNLEGTEQP-----ALTST----------PQ----YRSPRT-------
AqueK228_Aque DLIPCN-VEPGTPSRQG-SGGSGGNPPLPTPPLFTSDISVDPEESLS-LSALSFASSFFQ
B0414.7_Cele -----------------------WFRPLDENNKIFALE-DVRAVFLEYVKNSLNLKGMKK
Mekk1_Dmel SSEC---SHSHMRKGSMHDINIFSVEPLGTCSSNGTGE-QSTGLYRKFIENVLKSRGLAK
MAP3K4_Mmus SQGC---VSRKLERLESEEDSIGWGTAD--CGPEASRH-CLTSIYRPFVDKALKQMGLRK
MAP3K4_Hsap SRDC---ISKKLERLESEDDSLGWGAPDWSTEAGFSRH-CLTSIYRPFVDKALKQMGLRK
MEKK4_Spur ---D---ESPRTNRIFSE------------CHFSFDYD-SSTSIYRPFVDRSLKHQGLRK
AqueK228_Aque TQNSISSSRGTLQRLFSSRN-IY----------SIDEERVSSKGYSRFVDQVLKRKSLDW
. : ::.. *: .:
B0414.7_Cele VLSRVEKIIELTLVKTAILMQKPPT----SYAAA-----------TA-----SNGPSF--
Mekk1_Dmel SLAFLHKLHNVALYKAHIALEKPGA---EDF-DYE-----SDAESIE-----EDVPRL--
MAP3K4_Mmus LILRLHKLMNGSLQRARVALVKD--DRPVEFSDFPGPMWGS---D---------YVQL--
MAP3K4_Hsap LILRLHKLMDGSLQRARIALVKN--DRPVEFSEFPDPMWGS---D---------YVQL--
MEKK4_Spur MTKRLDKMLGHTMRKIRLALEKMKLDTLIEFMDHKCPMWYSLQSDIDLTLKPSGTPQF--
AqueK228_Aque LIEKLIKSIKPILKTAKEAMKQLEV--EEDKSEDSDNE--DNSSFLE-RLSPFRLIHFGG
: * : : : . :
B0414.7_Cele P-FSQTMKDRY--GDMIEWRFCNSTSISLNLPPLNNLFFFLVAVPMQLVVHWLEIRAATE
Mekk1_Dmel --DPEISREQV--VELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETR
MAP3K4_Mmus SGTP-PSSEQKC--S---AVSW-EELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR
MAP3K4_Hsap SRTP-PSSEEKC--S---AVSW-EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR
MEKK4_Spur FETPSPSTEQTHGTQLQSHGAWSKEFQDMSLPSFMPAYLFLVRIPLDVMHECLRFRLEHK
AqueK228_Aque VSTPGPAQMKRA--SSVAPKCWNDEFQDMNLPPFAEQYLRLTRVPLDIMQESMRLRTEVN
. . . . :.**. :. * : ::.: . :.:* .
B0414.7_Cele PPDSCLLDELTFDAMITDSRDCVEEAVRIKKNYLTILQS-MCSKCAMPG-FL-YPL-KYN
Mekk1_Dmel PV-RP--NPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAEL-GSYISILNHYD
MAP3K4_Mmus PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLGG----LEKTDCNMDAFE
MAP3K4_Hsap PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLED----LEKPDCNIDAFE
MEKK4_Spur PEADP--SRHSIQQLIREYKEVIGACTHVKQYYHDMVSA-VTLGDVRAQEHVDNDIDDYE
AqueK228_Aque K--SP--TPYSVGMLVQESCVTLKKAVRVRKFYRSKVRL-LIANDPSGAELVDNDMACYE
:. :: : : :: * : : : ::
B0414.7_Cele TYVLDVFKKYIHYVKCWSNC-DSVRKDPPLLFSRLEMEWSSAVQCAKSVKSALELLCTTY
Mekk1_Dmel ATVRKTFELYLEYIDQLV--LVAVPEG--NQKSVLEKEWMFTKLISPMIKGMHTLASQKF
MAP3K4_Mmus EDLQKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF
MAP3K4_Hsap EDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF
MEKK4_Spur NDLQEMLQVYFEYVHSRMLMLQKLPQASVSLKNVLEEEWAFAKEMCPCIRGGEAQAGKRF
AqueK228_Aque KHLQSVLQLYFSYVERLV-------QVSSTDRNLLESQWEITKDICNDISTGEIEAGLRF
: . : *: *: : . ** :* : : :
B0414.7_Cele CDIVESLIREVVEVYADDQIEDIKNRYVYNTDSENEDEEDDEDMITIGSPKKPLVELKAK
Mekk1_Dmel CGIISKLLRSISER-LVKRTVELDQQIDG-TADTDDNEEVKWQLLTICRE----------
MAP3K4_Mmus CDIAGMLLKSTGSF-LESGLQESCAELWTSADDNGAADELRRSVIEISRA----------
MAP3K4_Hsap CDIAGMLLKSTGSF-LEFGLQESCAEFWTSADDSSASDEIRRSVIEISRA----------
MEKK4_Spur CIMASNLLHSTAEY-LEQRVDDECAHLQD---SHSGGGAIKRIITGSCRK----------
AqueK228_Aque CSMASQLIENLEVD-LKSRIDDCCDKLHEHSNNLDDPDERKHAFIELCRE----------
* : *:.. : . . . .
B0414.7_Cele HRFMLELNSLTREVKERELRIFSLLRITLNDSHDAVGYELRSGVD---------------
Mekk1_Dmel ------TQSLLTVERERSIKVLFFAKTFCRDVETT-DFHREHYEHDVA------------
MAP3K4_Mmus ------LKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARELLDALKAKQYVKVQ
MAP3K4_Hsap ------LKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQ
MEKK4_Spur ------FRELFHEVRDRAAKALGFAKMLTKDLEIASEFTLNTSLGDLMNNLKLSSHVKVK
AqueK228_Aque ------FKSIIQKSRESSMKGLGFSKTLMTDLEIAAEFSITCTRE-------------VI
..: :: : : : : * . : :
B0414.7_Cele --RA-QMFHEMVPDF------CLIQLTMA---------SDEQGDVNDDDDHVNLKIVLFV
Mekk1_Dmel -----------------NQ-----------------------------------------
MAP3K4_Mmus IPG-LENLHVFVPDSLAEEKKIILQLLNAATGKDC---------SKDP-DDVFM------
MAP3K4_Hsap IPG-LENLQMFVPDTLAEEKSIILQLLNAAAGKDC---------SKDS-DDVLI------
MEKK4_Spur MLGIFPGYQVFVPQHLHQNTPQILHLLNDLCGREDFL------STSDPSSPDAS------
AqueK228_Aque IPQ-YHACMLFVPHNIADNQQEIQKLLGVSFGHPVVEVGGPGGHSHR-HSVHYN------
B0414.7_Cele YRTSVDKAYVETCMLAISEGRKIDDGCIVIVPD--KDHKL---RKHWKGRVVKIVIDEET
Mekk1_Dmel ------------------------------------------------------------
MAP3K4_Mmus ------------------------DAFLLLTKHGDRARDSEDGWGTWEARAVKIVPQVET
MAP3K4_Hsap ------------------------DAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVET
MEKK4_Spur ------------------------DGYLLLVKD--EEREAE---SKWGGDTTSVNPNIET
AqueK228_Aque ------------------------DSYLLFVKFSA-AGDS---IPIWTGEKINLTLSAET
B0414.7_Cele RICYRWLRDDIILCLANGSIRADMEHKYKNFLKCI-------SPACSSNFLITSRIQQLT
Mekk1_Dmel -----------------------------------------QHDFIC--SDVKAAFKLLQ
MAP3K4_Mmus VDTLRSMQVDNLLLVVMESAHLV--LQRKAFQQSIEGLMTVRHEQTSSQPIIAKGLQQLK
MAP3K4_Hsap VDTLRSMQVDNLLLVVMQSAHLT--IQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLK
MEKK4_Spur TIATSDIQVESILLVVNHSSQLT--TQRKAFQRAMGSTVTLINEQTSSHNTIAEALGELK
AqueK228_Aque IVSISEMQVEGIKLVVNDSSRLE--RNQMSFLRCMGTNVEITNKRTSSHHSVAERINELK
. : : *
B0414.7_Cele EESLLPHLDEERKRIGILLEKTEIRL--EP--KEEQSKEKSALSSLGFKLEKHFLVAFQI
Mekk1_Dmel QDVL--QV---RNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEY
MAP3K4_Mmus NDAL--EL---CNRISDAIDRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEY
MAP3K4_Hsap NDAL--EL---CNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEY
MEKK4_Spur DNAL--TL---CETLVAAICQVEENLILDSMVDVEESERNNILKYSRDGMCQCFSVGFEY
AqueK228_Aque LVLC--HF---GHTIIEIVERVSGNLSLE-----EISEREDLLQQYLPTMHACYNFGFE-
. . : : .. . : .. . : : ..*:
B0414.7_Cele HRDVAKVVSDSF-MD---------GLGNEMVEKALALTRQWMQYVEVKSTIPSPTLPMWA
Mekk1_Dmel HKDVIRLFEQKI-MDQKDSGAHTVDLAL----GIIAYAKMWMHFVMERCERGRGMRPRWA
MAP3K4_Mmus HKEVVRLMSGEF-RQ---------KIGD----KYISFAQKWMNYVLTKCESGRGTRPRWA
MAP3K4_Hsap HKEVVRLMSGEF-RQ---------KIGD----KYISFARKWMNYVLTKCESGRGTRPRWA
MEKK4_Spur HKEVSRLLSNK---R---------GLGE----SILKLAQQWMNFALNKWERGKGRRPRWA
AqueK228_Aque --DLSRLFGDEYIHQ---------KLGA----EMLHFSQQWIVFATTKCIRGHGKQPRWA
:: ::. . :. : :: *: :. : * **
B0414.7_Cele SPGFTFLQYITEPRWSNPEIMTNDQFQEFNDLVKLFEAKVIKSSSN--------------
Mekk1_Dmel SQGLEFLILACDPQIT--QHLDDDEFEALKQQMDRCISHVIGITSEPEK---VAKKKASP
MAP3K4_Mmus TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP
MAP3K4_Hsap TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP
MEKK4_Spur NQGLEFLILACEPRNV--AHLIEEEFQDLQRLMKQCIEHVIGKTTP-QSPD---------
AqueK228_Aque VLGLEFILLSCSPRML--STISPSRYENVKKQMERCLDHVIGEVP---------------
*: *: .* : . : .: :. :**
B0414.7_Cele ----------------IGTPGNTGTPMQR-NTRSTSSK----------------------
Mekk1_Dmel RT-------------------------RKTSSPATSRSRTPTRTPMSAGM-VL-------
MAP3K4_Mmus RPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDARTHGNSVAAAAAVAAAATTAAGRPGP
MAP3K4_Hsap RPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAA-AA-AAAAAAVAASRPSP
MEKK4_Spur ---------------RMGSPDFLGGKM--MRSRSSKSIRSSSSS----------------
AqueK228_Aque ------LLSSNTFSEAYTSPQYIGGWTRQ-KSRMKKSGNSLSRTPVIEERDE--------
: .
B0414.7_Cele ----------------T-------------------------------------------
Mekk1_Dmel -----N--------PNTPPLQSPPY-NKLLHPQFSLKEDV-SGTSYSPVDSSDYVDTPC-
MAP3K4_Mmus GGGDSVPAKPVNTAPDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRS
MAP3K4_Hsap SGGDSVLPKSISSAHDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRG
MEKK4_Spur ---------------DQ-SITSPTSMGDLRRIPSVERFLSITSSNTSPTEDRLDPGFPRY
AqueK228_Aque ----------FDAGADSSGIDSPVLSGD-ISFAASEPLYSL-P--KSPPTTMLIPKMDRG
B0414.7_Cele -----SSSSME-N-------------------------------HKRTRKENQMLKLQEL
Mekk1_Dmel ----QRS-------ANGELRLLVPQTPPTPASPGKSSLESTPLA---LRQERVRDAVNRL
MAP3K4_Mmus DSSGSTR-------RSWELRTLISQTKDSAS--------------KQGPIEAIQKSVRLF
MAP3K4_Hsap DSSGSTR-------RSWELRTLISQSKDTAS--------------KLGPIEAIQKSVRLF
MEKK4_Spur DKRASPNPGCSSPMPSNHVFRAVSRDPDYAPRGANNGTPTGPAGQRRDRRSHKVQALERL
AqueK228_Aque DSVAVYSSPLS-HTPSQEV--------------------PPPVNQRQIKFKTIEEECKRI
. . :
B0414.7_Cele EDKRNRIDYDNLQIGKVITDDNR--RNFVLATDKKITTKAPFQWALLDHIASGSFGS-VH
Mekk1_Dmel DMDLEDGLRERRLIGQVKSLNS---SDK-VHIR---ARSVHFRWHRGIKIGQGRFGK-VY
MAP3K4_Mmus EERRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY
MAP3K4_Hsap EEKRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY
MEKK4_Spur EQARNDKLQRESMIGRISDQHTS--H-EVVNIN---CKKVTFRWQRGFKIGEGQFGTTVY
AqueK228_Aque DKVRDDELRVKRIIGRVTERSGASVFELSRLTD---LKQSHFTWRRGRKLGEGQFGV-VY
: . **:: . * * ::..* :* *:
B0414.7_Cele RAMDIDSHRVIAAKVMRIQRENHKAIE---SEINIFRQLIHENLVKYYGVQVEDSDV---
Mekk1_Dmel TAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREEL---
MAP3K4_Mmus TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM---
MAP3K4_Hsap TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM---
MEKK4_Spur SCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYGVEIHRVRYPHS
AqueK228_Aque ECINLDRGEVQAVKMISLKEKSHNTVRDILSEVGVFQSINHKNIVHFHGVEIHDTDL---
.:. : . * * : :: . ..:. .*: :. : * *:*::.*:::.
B0414.7_Cele -IIFMEYCSQ--GTLERICHG--KMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIF
Mekk1_Dmel -LIFMELCSE--GTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIF
MAP3K4_Mmus -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIF
MAP3K4_Hsap -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIF
MEKK4_Spur VIGVLNHHSETRTTLKFVCHL--E--------------------HEISLIIKNMNDL---
AqueK228_Aque -YLFMEYCNQ--GTLWGAAKQ--GLEERMIRLYTRDLLRAVDVLHDRGIVHRDIKGANIF
.:: .: ** . *. :: ::::
B0414.7_Cele LDK-CTVLKLGDFGCSSRLVE-SSTVYGEFQTTAG---TPQFMAPEIYSYGEKDETTGSY
Mekk1_Dmel LVDGSNSLKLGDFGSAVKIQA-HTTVPGELQGYVG---TQAYMAPEVFTKTN-------S
MAP3K4_Mmus LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G
MAP3K4_Hsap LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G
MEKK4_Spur ---------------------NQHFMPYKIYSKMLSAYHNSYMAPEVINQTGK-----DK
AqueK228_Aque LSD-D-SVKLGDFGLSVQLHNVNKTAPQEIKHQRG---TIPYMSPEVVLMQ---------
:. :*:**:
B0414.7_Cele SGYGRSVDIWALGATVVNMMTGKVPFEG-QTR-HQIAFALCFRKQKPTYP-DIADKRPDV
Mekk1_Dmel DGHGRAADIWSVGCVVVEMASGKRPWAQFDSN-FQIMFKVG-MGEKPQAP-ES--LSQEG
MAP3K4_Mmus EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG
MAP3K4_Hsap EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG
MEKK4_Spur PGYGRQADIWSLGCVVIEMVTGKRPWHDYDHE-FTIMYKVG-EGAVPHIP-DA--MNPEG
AqueK228_Aque -DMGRPMDIWAVGCVVVEMFTSKRPWIELEDNAMAIMFQLG-NKKSPSYPAEK--MNDEM
. ** ***::*..*::* :.* *: : . * : : * * : :
B0414.7_Cele KRFFDNCFEFLPNDRPTAAELLQTTFANVNITDENHIPDYQSQSSKDKSSPSSFFLV
Mekk1_Dmel HDFIDHCLQHDPKRRLTAVELLEHNFCKYGR-DECSSEQLQMQVRGSFRRNVATSSS
MAP3K4_Mmus KAFLSHCLESDPKIRWTASQLLDHAFVKVCT-----------------------DEE
MAP3K4_Hsap KDFLSHCLESDPKMRWTASQLLDHSFVKVCT-----------------------DEE
MEKK4_Spur KEFLSNCLKHDCTKRWTANKLLDHPFLKVK-------------------------YV
AqueK228_Aque IDFLDLCFETDPKQRAVASKLLSHSFVKVMD--S------------------CDDNS
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