RIOK3_Hsap      MDLVGVASPEPGTAAAWGPSKCPWAIPQN---TISCSLADVMSEQLAKELQLEEEAAVFP
CG3008_Dmel     MS-------------------SPWVKTSE--PVQQVNLADIMSEQYAHKLHDKELQRHTE
RIOK3_Mmus      MDLVGVSSPEPGPAAAWGPSKCPWATPQN---TVSCSLTEVMSEELAKELQLEEEAAAFP
ZK632.3_Cele    MAN---CENNPWK-------KNAWGKNEETAEEPIVSFADVLSEEFIEDLSVQEKLEEER
RIO3_Spur       ML----------------------------------------------------------
AqueK051_Aque   MDS-GLNTLSPHKP---TPTKSPWGSPMP--ATPTCSLASVMDEELARSFQAEEEKLLKK
                *

RIOK3_Hsap      E---------------------------------------VAVAEGPFITGENIDTSSDL
CG3008_Dmel     KLKRPDEQIAPVWGSQASSPPAPNAQSIQSDAEDWEDYSALLNDEGNVAEDIQLPEDSDA
RIOK3_Mmus      E---------------------------------------VVVAEGPFISGENIDTSSDL
ZK632.3_Cele    YMKQLDQMFGD-----------------------------TSVSDDQLP--INTEGMTDE
RIO3_Spur       --------------------------------------------------EEGKETDSDL
AqueK051_Aque   EMERPVPSVSP-----------------------------VGNEELPINGGGAESTDSDF
                                                                         :*

RIOK3_Hsap      MLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYE-DSD--S-SEDE--V
CG3008_Dmel     VIAQLLQSQFDHEYNEELRRIERQQNKQSKVTVTLNKFLRDGDAEFLHDTAEDDYEEDEL
RIOK3_Mmus      MLAQMLQMEFDREYDAQLRREEKKFNGDSKVSISFENYRKVHPFE-DSD--S-SEDE--V
ZK632.3_Cele    EVALALQRHFDREADVA-----RAVGSSSSVHFTPDRYH---PKT-MQE-TDSENEDDDA
RIO3_Spur       LLAQMLQLQFNREYDAELSREEQKYNKDSKVGISFSNYRSVHPAY-DDN--E-DDDDDDD
AqueK051_Aque   LLAQMLQLEFDKEHDRQLTAEEKHYNKQSRVKISFDNYRSLHPAY-LNH--Q-EEEEEE-
                 :*  ** .:::* :       :  . .* * .: ..:          .  . . ::

RIOK3_Hsap      DWQD----TRDDPYRPAKPVPTPKKGFIGKG-KDITTKHDEVVCGRKNTARME-NFAPEF
CG3008_Dmel     EQQKHDWDRFEDNERQLDSIPRCGFK-VNKE-GEMITKHDPQLCAVRNAQRVM-SFPPEF
RIOK3_Mmus      DWQD----TRDDPYRPAKPIPTPKKGFIGKG-KDITTKHDEVVCGRKNTARME-NFAPGF
ZK632.3_Cele    LRQAA----TDMLYAKLDEENATNSRLRPEGPSTSRTKHDTGVSGRRNADKTF-NDRNTL
RIO3_Spur       DYQE-EW-ILGDEGREAELLAPPSPS-PGQK-KSIVTKHDAQVCGRKNASRVMNQFPPAF
AqueK051_Aque   --------VVDDEYEMTVRIPRSSGRKKGVS-PGQPTKHDSKICGQKNVRNME-KFPPDF
                                                    ****  :.. :*. .   .    :

RIOK3_Hsap      QVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVN
CG3008_Dmel     PTGDAAGFDMKLSNKVFNQLRAHSRRG-----RSDKHEKVATAEMGLDAGTRLLLYKLIN
RIOK3_Mmus      QVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVN
ZK632.3_Cele    PTGDMVG--DKLNNKVFNKLMAFGKSESKRQMRNKDKEEKATMDTSVDSDTRLLLLKWIN
RIO3_Spur       PTGNSFGMDMKLSNSVYNVLKIHSQKEESKAQRLHEKKEHSTAEMAVDSRTRIMLYKLVN
AqueK051_Aque   PMGDVQ-PGLCLDNSVFNVLKEHSMREEKQSQRHHEKKEHSTQEHVLDPKTRLMLFKMVD
                  *:       *.* *:* *  ..        * ..::: :* :  :*. **::: * ::

RIOK3_Hsap      SGMLETITGCISTGKESVVFHAYG-----GSMEDEKE-----DSKVIPTECAIKVFKTTL
CG3008_Dmel     NQILEQINGIISTGKEAVILHANSDANYTGSNEHGHQSGVLVPPQLLPRECAIKIFKTTL
RIOK3_Mmus      SGMLETITGCISTGKESVVFHAYG-----GSLEDEKE-----DGKAIPTECAIKVFKTTL
ZK632.3_Cele    QGVFDSVDGIIATGKESAVLHAAQ-----DS----------------ATSYAIKVYKTTL
RIO3_Spur       NGMLDSITGTISTGKEAVVIHAYG-----GQIDD----------HIIPPECALKVFKTTL
AqueK051_Aque   SGKLGEVNGCLSTGKEAAVYHAEG-----GG---ELE-----DGTAVPDECAIKIFKTTL
                .  :  : * ::****:.: **       .                 . . *:*::****

RIOK3_Hsap      NEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHI
CG3008_Dmel     NEFKQRDRYIKDDYRFKDRFSKQNHRVIINMWAEKEMHNLMRMQAIGLNVPDVVVLKKHV
RIOK3_Mmus      NEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHI
ZK632.3_Cele    SEFKNRSEYVKDDFRFK------NPRGVLKIWAEREFMNLSRMAKHGLPCPQPVKVRRNV
RIO3_Spur       NEFKKRDQYIRNDYRFRARFKKQNPRKFIQMWAEKEMHNLNRMREAGIRCPEVVLLRKHI
AqueK051_Aque   NEFFRRDKYIKEDYRFKNRFGKQNPRKIVRLWAEKEMHNLKRLHSHGIHCPKVVLLKKHV
                .** .*..*:::*:**:      * * .:.:***:*: ** *:   *:  *  * :::::

RIOK3_Hsap      LVMSFIGHDQVPAPKLKEVK---LNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNML
CG3008_Dmel     LVMRFIGDNHNAAPKLKDAR---LSDAELSCAYEEIVAAMHKLYNEAKLVHADMSEYNIL
RIOK3_Mmus      LVMSFIGHDQVPAPKLKEVK---LSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNML
ZK632.3_Cele    LVMSFLGDQGLAAPRLKNVEWEFFTDDERRNVYDQVQSIMCRMYKECLLVHADLSEFNLL
RIO3_Spur       LVMSYIGKDQKAALKLKHVK---FSVSEAQCVYEECLE----------------------
AqueK051_Aque   LVMSFIGKDQIPAPKLKDSQ---LTQDQLKSAYHQCVQTMEKMYNDCHLVHADLNEFNML
                *** ::*.:  .* :**. .   :.  :   .* :

RIOK3_Hsap      WH-AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLN
CG3008_Dmel     WF-EGKCWFIDVAQSVEPKHPSALEFLMRDCGNIVNFFERRGLPNIYTKEQLFEFITGLN
RIOK3_Mmus      WH-AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSGLN
ZK632.3_Cele    LTPDNKVHVIDVSQAMDLSHPRSLQFLTRDIQNIITFFTRIGTPNLPTYVQLFNLITDLD
RIO3_Spur       ------------------------------------------------------------
AqueK051_Aque   WF-EGRVYIIDVSQSVEPSHPHGLEFLLRDCKNVSTYFSKKGLAETLSHQDLFNKITGLG


RIOK3_Hsap      ITADNEADFLAEIEALEKMN----------------------------------------
CG3008_Dmel     SE-VHTAAQLEQI---HTRGASISQATAPNQEECPDELKPLEYPFELAWEKSQQDRAAQK
RIOK3_Mmus      ISADNEADFLAEIEALEKMN----------------------------------------
ZK632.3_Cele    MVE--DHDLLVQVEQFSEENRSVDL--------RHD--KSR--PADMELKKYNEEKKA--
RIO3_Spur       ------------------------------------------------------------
AqueK051_Aque   ISAVDDQEFLTQIRAYTQRQQLLDV--------IYD--KKEPYPFDFFFEETMNSRQDNS


RIOK3_Hsap      ------------------EDHVQ-KNGRKAA-S---FLKDDGDPPLLYDE
CG3008_Dmel     A---------LQQAQDNNDNKTD-TDKDQETDDNENDSDDKEKINKTANH
RIOK3_Mmus      ------------------EDHIQ-KNGRKAA-S---FLKDDGSPPVLSAD
ZK632.3_Cele    ---------------------------------------NRGISPAREYN
RIO3_Spur       ------------------------------------------------VR
AqueK051_Aque   GSIGVDVKRGKKDL---NESKSSESNEEEVL-S---ETEEETDSDSTDED