RSK4_Hsap        FELLKV--LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK--ASLKVRD---RVRTKMERD
RSK4~b_Hsap      YELKED--IGVGSYSV---CKRCIHATTNMEFAVKIIDK--SKR---------DPSEEIE
RSK3_Hsap        FELLKV--LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK--ATLKVRD---RVRSKMERD
RSK3~b_Hsap      YEIKED--IGVGSYSV---CKRCVHKATDTEYAVKIIDK--SKR---------DPSEEIE
RSK2_Hsap        FELLKV--LGQGSFGKVFLVKKISGSDARQLYAMKVLKK--ATLKVRD---RVRTKMERD
RSK2~b_Hsap      YEVKED--IGVGSYSV---CKRCIHKATNMEFAVKIIDK--SKR---------DPTEEIE
RSK1_Hsap        FELLKV--LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK--ATLKVRD---RVRTKMERD
RSK1~b_Hsap      YVVKET--IGVGSYSE---CKRCVHKATNMEYAVKVIDK--SKR---------DPSEEIE
S6k_Dmel         YNLLQE--LGRGTFSV---CRLCEHRASKKHYAVKVIEK--AAVAAASTSTSADCWEEVE
S6k~b_Dmel       FELLRV--LGEGSFGKVFLVRKIIGKDAGTLYAMKVLKK--ATLKVKD---RVRSTNERK
RSK1_Mmus        FELLKV--LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK--ATLKVRD---RVRTKMERD
RSK1~b_Mmus      YVVKET--IGVGSYSV---CKRCVHKATNMEYAVKVIDK--SKR---------DPSEEIE
RSK2_Mmus        FELLKV--LGQGSFGKVFLVKKISGSDARQLYAMKVLKK--ATLKVRD---RVRTKMERD
RSK2~b_Mmus      YEVKED--IGVGSYSV---CKRCIHKATNMEFAVKIIDK--SKR---------DPTEEIE
RSK3_Mmus        FELLKV--LGQGSYGKVFLVRKVTGSDAGQLYAMKVLKK--ATLKVRD---RVRSKMERD
RSK3~b_Mmus      YEIKED--IGVGSYSV---CKRCVHKATDAEYAVKIIDK--SKR---------DPSEEIE
RSK4_Mmus        FDLLKV--LGQGSFGKVFLVRKKTGPDAGQLYAMKVLRK--ASLKVRD---RVRTKMERD
RSK4~b_Mmus      YELKED--IGIGSYSV---CKRCIHSASNVEFAVKIIDK--NKR---------DPSEEIE
T01H8.1a_Cele    FELLKV--LGQGSFGKVFLVRKVRGRDSGHVYAMKVLKK--ATLKVRD---RQRTKLERN
T01H8.1a~b_Cele  YEILEK--IGNGAHSV---VHKCQMKATRRKYAVKIVKK--AVF---------DATEEVD
RSK1_Spur        YDLQED--IGLGSYSV---CKRCTHKATGQDYAVKIIKK--NTK---------DVREEIE
RSK2_Spur        ------------------------------------------------------------
AqueK025_Aque    FELVKV--LGQGSFGKVFLVRRLVGHDAGKLYAMKVLKK--ATLKVRD---RIRTKMERD
AqueK025~b_Aque  YDIKEDMLLGYGSYSR---CVRCIHRATNQEFAVKIISKEKSTR---------DVDEEIE


RSK4_Hsap        ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAEL
RSK4~b_Hsap      ILMRY-GQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILK-QKCFSEREASDILYVI
RSK3_Hsap        ILA-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK3~b_Hsap      ILLRY-GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILR-QRYFSEREASDVLCTI
RSK2_Hsap        ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK2~b_Hsap      ILLRY-GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLFTI
RSK1_Hsap        ILA-D-VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK1~b_Hsap      ILLRY-GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSEREASFVLHTI
S6k_Dmel         IMLRY-GNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILA-VGQMCESEASAVLRTI
S6k~b_Dmel       ILA-D-VGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK1_Mmus        ILA-D-VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK1~b_Mmus      ILLRY-GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSEREASFVLHTI
RSK2_Mmus        ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK2~b_Mmus      ILLRY-GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLFTI
RSK3_Mmus        ILA-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
RSK3~b_Mmus      ILLRY-GQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILR-QRCFSEREASDVLYTI
RSK4_Mmus        ILV-E-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAEL
RSK4~b_Mmus      ILMRY-GQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILK-KKCFSEQEASNVLYVI
T01H8.1a_Cele    ILA-H-ISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEDDVKFYLAEL
T01H8.1a~b_Cele  ILLRH-SHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANL
RSK1_Spur        ILLRY-GHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLK-QKFLSEREACEIMLTV
RSK2_Spur        ------------------------------------------------------------
AqueK025_Aque    ILA-D-VRHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSK-EVMFTEEDVKFYLAEL
AqueK025~b_Aque  ILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIIS-QKFFSEKEAAAVLAIL


RSK4_Hsap        ALALDHLHQLGIVYRDLKPENILL-DEIG---HIKLTDFGLSKESVDQEKKAYSFCGTVE
RSK4~b_Hsap      SKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTAN
RSK3_Hsap        ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKITDFGLSKEAIDHDKRAYSFCGTIE
RSK3~b_Hsap      TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN
RSK2_Hsap        ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKESIDHEKKAYSFCGTVE
RSK2~b_Hsap      TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN
RSK1_Hsap        ALGLDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKEAIDHEKKAYSFCGTVE
RSK1~b_Hsap      GKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTAN
S6k_Dmel         ASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTAN
S6k~b_Dmel       ALAMNHLHTLGIIYRDLKPENILL-DEHG---HIALTDFGLSKQPLDG-SKTYSFCGTVE
RSK1_Mmus        ALGLDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKEAIDHEKKAYSFCGTVE
RSK1~b_Mmus      SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTAN
RSK2_Mmus        ALALDHLHSLGIIYRDLKPENILL-DEEG---HIKLTDFGLSKESIDHEKKAYSFCGTVE
RSK2~b_Mmus      TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN
RSK3_Mmus        ALALDHLHGLGIIYRDLKPENILL-DEEG---HIKITDFGLSKEATDHDKRAYSFCGTIE
RSK3~b_Mmus      ARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN
RSK4_Mmus        ALALDHLHRLGIVYRDLKPENILL-DEIG---HIKLTDFGLSKESVDQEKKAYSFCGTVE
RSK4~b_Mmus      TKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTAN
T01H8.1a_Cele    TLALEHLHSLGIVYRDLKPENILL-DADG---HIKVTDFGLSKEAIDSEKKTYSFCGTVE
T01H8.1a~b_Cele  LNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQ
RSK1_Spur        TRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTAN
RSK2_Spur        ------------------------------------------------------------
AqueK025_Aque    ALALHHLHGLGIVYRDLKPENILL-DADG---HIKLTDFGLSKESVD-DKKTFSFCGTVE
AqueK025~b_Aque  TDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAENGLLMTPCYTAN


RSK4_Hsap        YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL----KAKL-G--
RSK4~b_Hsap      FVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPN-DTPEEILLRIGNGKF-SLS
RSK3_Hsap        YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL----KAKL-G--
RSK3~b_Hsap      FVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPD-DTPEEILARIGSGKY-ALS
RSK2_Hsap        YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL----KAKL-G--
RSK2~b_Hsap      FVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIGSGKF-SLS
RSK1_Hsap        YMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL----KAKL-G--
RSK1~b_Hsap      FVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKF-TLS
S6k_Dmel         FVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPN-DSPDVILKRIGSGQI-DFT
S6k~b_Dmel       YMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQIL----RSKL-G--
RSK1_Mmus        YMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL----KAKL-G--
RSK1~b_Mmus      FVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKF-TLS
RSK2_Mmus        YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL----KAKL-G--
RSK2~b_Mmus      FVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIGSGKF-SLS
RSK3_Mmus        YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL----KAKL-G--
RSK3~b_Mmus      FVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPD-DTPEEILARIGSGKY-ALS
RSK4_Mmus        YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL----KAKL-G--
RSK4~b_Mmus      FVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPN-DTPEEILLRIGNGRF-SLS
T01H8.1a_Cele    YMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQIL----KAKL-S--
T01H8.1a~b_Cele  FVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPN-DTPDQILQRVGDGKI-SMT
RSK1_Spur        FVAPEVLKKQGYDAACDIWSLGVILYTMLAGFTPFVHKPD-DSSKVILARIQEGKYLTMN
RSK2_Spur        ------VNDRGHSQISNYFSLSTVQYEMLTGALPFQGQHRKETMALIL----KAKL-G--
AqueK025_Aque    YMAPEVVNRKGHDITADWWSFGVLMYEMLTGSLPFQGENRKATMNMIL----KAKL-G--
AqueK025~b_Aque  YVAPEVLKKQGYDAAIDIWSLGVLLYTMLAGECPFAAGPD-DGPDKILSRISEGKI-NLT
                       :  :*:    : :* . : . **:*  **           **     .:

RSK4_Hsap        --MPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF
RSK4~b_Hsap      GGNWDNISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWI
RSK3_Hsap        --MPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
RSK3~b_Hsap      GGNWDSISDAAKDVVSKMLHVDPHQRLTA-----MQVLKHPWV
RSK2_Hsap        --MPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
RSK2~b_Hsap      GGYWNSVSDTAKDLVSKMLHVDPHQRLTA-----ALVLRHPWI
RSK1_Hsap        --MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
RSK1~b_Hsap      GGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWV
S6k_Dmel         SSRWALISVPAKELLRQMLHIVPENRPTA-----ARILEHDWL
S6k~b_Dmel       --MPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
RSK1_Mmus        --MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
RSK1~b_Mmus      GGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWI
RSK2_Mmus        --MPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
RSK2~b_Mmus      GGYWNSVSDTAKDLVSKMLHVDPHQRLTA-----ALVLRHPWI
RSK3_Mmus        --MPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
RSK3~b_Mmus      GGNWDSISDAAKDVVSKMLHVDPQQRLTA-----VQVLKHPWI
RSK4_Mmus        --MPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEVKRHAFF
RSK4~b_Mmus      GGIWDNISRGAKDLLSHMLHMDPHQRYTA-----EQVLKHPWI
T01H8.1a_Cele    --MPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
T01H8.1a~b_Cele  HPVWDTISDEAKDLVRKMLDVDPNRRVTA-----KQALQHKWI
RSK1_Spur        GGNWDNISDRAKDLISRMLHVDPFQRPST-----KQVLQHTWF
RSK2_Spur        --MPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
AqueK025_Aque    --MPQFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
AqueK025~b_Aque  GGNWDTVSAAAKDLVLRMLHVDPQQRCTA-----AQILQHPWI
                       ::  *:.::  ::.  . .*             * :