8635_Tthe -----------------------------AMKVVDKKRK---------------------
8635~b_Tthe -DQSEIN-------------EQIKRQSQ--------------------------------
PLK4_Hsap -FK-VGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAM---------------------
5034_Tthe -YI-ISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQ---------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur -YQ-VLNLLGRGGFACVYRAKTISTGQEVAIKMIDKKLM---------------------
PLK4_Mmus -FK-VGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAM---------------------
SAK_Dmel -YE-VQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLI---------------------
zyg-1_Cele -YS-HLKEIGKGGFGVVYAAQR-ENGEKVAIKRVSFMLFSKDIRMGQFFYFFSLQKLYFQ
AqueK201_Aque DYE-VLNRLGKGSFADVYRAKCKRTKKEVAIKMIDKKLM---------------------
8635_Tthe -DIQNVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNI---
8635~b_Tthe IVQKKDDLKILNEIEIIGDIQNI-EQINKG-----------GFGSIQKGKLAKILKYPLY
PLK4_Hsap -YKAGMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR--
5034_Tthe -YYKSAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKH---
21183_Tthe ---------------LHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINF
SAK_Spur -QSSGMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNGELLRYLKKK--
PLK4_Mmus -YKAGMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR--
SAK_Dmel -QGTGLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI--
zyg-1_Cele IDKKVPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREH--
AqueK201_Aque -VKKGMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNGELNRYLKHR--
:.: :: : *.: :
8635_Tthe ----NK----------PYQLACGIKYLHDKDIVHRDLKLNNVLLSN-----GKIKIADFG
8635~b_Tthe G-HFSQTMSLITKLYIMWQIAQGIQFLTSKNVAHLDLKPANIVISK----GYLAKIIDFG
PLK4_Hsap ----VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR----NMNIKIADFG
5034_Tthe ----HKKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSS----DHQVKICDFG
21183_Tthe QLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTG----NNSVKICDFG
SAK_Spur ----ARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLTR----DMHCKIADFG
PLK4_Mmus ----MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTR----NMNIKIADFG
SAK_Dmel ----ARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSR----EMHVKIADFG
zyg-1_Cele -----GALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFG
AqueK201_Aque ----QKSLSEDE-RIILNQVVKGLIYLHSFNIVHRDLSLSNILLTS----SMDIKIADFG
:: .: :: : * *:. *:.:. *: ***
8635_Tthe LATKVNDE-------------NPECNTMCGTANYLSP-----------------EILN--
8635~b_Tthe EAYHPDVCNGKEFYNNQQRLIFKSYFLMKGNPNYKPG-----------------RTLPYT
PLK4_Hsap LATQLKMP-------------HEKHYTLCGTPNYISP-----------------EIAT--
5034_Tthe LAVRLNGN-------------EQEKNTICGTPNYISP-----------------EILN--
21183_Tthe LAVRVTNY-------------ESERDTFCGTPNYIAP-----------------E-----
SAK_Spur LAAQLKLP-------------EEQHYTMCGTPNYISP-----------------EIAT--
PLK4_Mmus LATQLNMP-------------HEKHYTLCGTPNYISP-----------------EIAT--
SAK_Dmel LATQLKRP-------------DERHMTMCGTPNYISP-----------------EVVS--
zyg-1_Cele LATTLGRG--------------ETTCTIVGTPGFIAP-----------------QVYD--
AqueK201_Aque LSVTLDLP-------------GDKHHTLCGTPNYIAPYVICCYEGCFLIFIFCREVAK--
: : *...: . .
8635_Tthe -------SKGYGKKTDIWSFGCILYALCSGNLPFFSGNPSQTIQNIK----E--------
8635~b_Tthe PYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFK--RGALHKLEEKFSRGDIRGRLV
PLK4_Hsap -------RSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----L--------
5034_Tthe -------KQPYGMKIDCWSFGCILYALIVGHPPFQGQDIVQTLKKVT----S--------
21183_Tthe ---------KYGIQSDCWSFGCILYTIATGRPPFETVSIQQTLKMLQ----K--------
SAK_Spur -------RGPHGLQSDVWSLGCMLYTFLTGTPPFDTEAVKTTLNKVM----L--------
PLK4_Mmus -------RSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----L--------
SAK_Dmel -------RTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVV----M--------
zyg-1_Cele --------QEYTQSADVYSLGAVLYTMLTARNPPPKGLP-P-------------------
AqueK201_Aque -------REAHGLESDIWSLGCMVYTMLVGTPPFDTDDVQSTLDNVV----N--------
* :*.* :. : *
8635_Tthe GK---WQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
8635~b_Tthe KNYQRHFGPKHIINLLHCLIFRCID-EKENRPTIDWI---ILI
PLK4_Hsap AD---YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
5034_Tthe QEQ-FFELPNNISDNLKDLLVNIINWNQDSRFTIDQILMHPFY
21183_Tthe KN--KVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKSHPFY
SAK_Spur AE---YIIPTHISMEAKDLINKMLRKDPTERIGLSTVLDHPFM
PLK4_Mmus AD---YEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM
SAK_Dmel SE---YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFM
zyg-1_Cele --------TCGMSPNAARLVEQMMDTDAKKRIPLTQIVLSEFM
AqueK201_Aque GD---FDIPQYITTNCTSLNLH--VYHPSKRLTLQQVLYHS-F
. : * . * : :