N171

Kinase Glossary: N171

N171 is a highly conserved residue in ePK and most PKL kinases. It co-ordinates the second Mg++ ion used during catalysis. Within ePKs it is almost completely conserved, but is changed to a serine in PAKB kinases and in the MTRK family of PKL kinases. The number 171 is based on the position of this residue in the first PKA kinase crystal, 1ATP [1].

1. Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, and Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. DOI:10.1107/S0907444993000423 |