TBK1_Hsap WLLSDILGQGATANVFRGR-----------------------------------------
IKKe_Hsap WHTDDLLGQGATASVYKAR-----------------------------------------
IKKb_Hsap WEMKERLGTGGFGNVIRWH-----------------------------------------
IKKa_Hsap WEMRERLGTGGFGNVCLYQ-----------------------------------------
ird5_Dmel WERCRNLGEGGFGLVIHWR-----------------------------------------
ik2_Dmel WCTTSVLGKGATGSVFQGV-----------------------------------------
IKKe_Mmus WHTDDLLGQGATASVYKAR-----------------------------------------
IKKb_Mmus WEMKERLGTGGFGNVIRWH-----------------------------------------
IKKa_Mmus WEMRERLGTGGFGNVSLYQ-----------------------------------------
TBK1_Mmus WLLSDILGQGATANVFRGR-----------------------------------------
TBK1_Spur WYLKDVLGTGATSSVYLGR-----------------------------------------
IKKe_Spur IFLDTPLGQGATSKVYGGR-----------------------------------------
IKKa_Spur WQFKKLLGSGSFGEVLLYQLGVGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCGVWLA
AqueK157_Aque NWRRAPIGRGSFGDVSLFT-----------------------------------------
AqueK158_Aque WSSKDKLGQGATGQVFAGY-----------------------------------------
:* *. . *
TBK1_Hsap ------------------------------------------------------------
IKKe_Hsap ------------------------------------------------------------
IKKb_Hsap ------------------------------------------------------------
IKKa_Hsap ------------------------------------------------------------
ird5_Dmel ------------------------------------------------------------
ik2_Dmel ------------------------------------------------------------
IKKe_Mmus ------------------------------------------------------------
IKKb_Mmus ------------------------------------------------------------
IKKa_Mmus ------------------------------------------------------------
TBK1_Mmus ------------------------------------------------------------
TBK1_Spur ------------------------------------------------------------
IKKe_Spur ------------------------------------------------------------
IKKa_Spur SLWCLVGVVVVSGWRRCGVGLVSMSSQFGVDANVGLASMWCHFGLVCGVDEESVCPRCGV
AqueK157_Aque ------------------------------------------------------------
AqueK158_Aque ------------------------------------------------------------
TBK1_Hsap -------------------HKKTGDLFAIKVFNNISFLRPV---------DVQMREFEVL
IKKe_Hsap -------------------NKKSGELVAVKVFNTTSYLRPR---------EVQVREFEVL
IKKb_Hsap -------------------NQETGEQIAIKQCRQELSPRNR---------ERWCLEIQIM
IKKa_Hsap -------------------HRELDLKIAIKSCRLELSTKNR---------ERWCHEIQIM
ird5_Dmel -------------------NRTTGREIATKHIKEMGALS-ADQQVKL--SERWNKELNWS
ik2_Dmel -------------------NKITGESVAVKTFNPYSHMRPA---------DVQMREFEAL
IKKe_Mmus -------------------NKKSGEVVAVKVFNSASYRRPP---------EVQVREFEVL
IKKb_Mmus -------------------NQATGEQIAIKQCRQELSPKNR---------DRWCLEIQIM
IKKa_Mmus -------------------HRELDLKIAIKSCRLELSSKNR---------ERWCHEIQIM
TBK1_Mmus -------------------HKKTGDLYAVKVFNNISFLRPV---------DVQMREFEVL
TBK1_Spur -------------------HKKNGDVVAVKMFNHLSYMRPR---------DVQQREFEVL
IKKe_Spur -------------------HKKLGKRVACKVPHTANLFRMG---------TDMERESQVL
IKKa_Spur GLVLMWSQFGVDVVSVRRQCGETSEYIALKRCKSILQLENL---------KRWRDEVEFM
AqueK157_Aque --------------------SNDGEQIALKEMKLE-PLRNLDSHERDKMIVRLRNEIKIM
AqueK158_Aque -------------------SKRSGDKVAIKMFTSPSEYKAM---------QSEMQTIKAL
. * * :
TBK1_Hsap KKL-NHKNIVKLFAIEEE-----T----TTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLP
IKKe_Hsap RKL-NHQNIVKLFAVEET-----G----GSRQKVLVMEYCSSGSLLS-VLESPENAFGLP
IKKb_Hsap RRL-THPNVVAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRK-YLNQFENCCGLR
IKKa_Hsap KKL-NHANVVKACDVPEE-----LNI-LIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLK
ird5_Dmel RQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRK-RLQSPENANGLT
ik2_Dmel KKV-NHENIVKLLAIEED-----Q----EGRGKVIVMELCTGGSLFN-ILDDPENSYGLP
IKKe_Mmus RRL-NHQNIVKLFAVEET-----G----GSRQKVLIMEYCSSGSLLS-VLEDPENTFGLS
IKKb_Mmus RRL-NHPNVVAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRR-YLNQFENCCGLR
IKKa_Mmus KKL-DHANVVKACDVPEE-----LNF-LINDVPLLAMEYCSGGDLRK-LLNKPENCCGLK
TBK1_Mmus KKL-NHKNIVKLFAIEEE-----T----TTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLP
TBK1_Spur LKL-NHKNIIHLDQIEED-----Q----ISKQPVIVMELCTGGSLYT-YLDTPENLYGLK
IKKe_Spur LRL-RNQNIVCLEAIEKD-----Q----ISKENILIMELCTGGSLYD-VLEKPENSCGLA
IKKa_Spur RNL-EHPNIVQGRPVPPE-----LEA-KPNEPPCLAMEFCSRGDLRK-KLSELPNMCGLP
AqueK157_Aque WEH-NHPNLIKALGPPPD-----IPYHPPEDVMHVWMEFCNGGDLRNGVLKKIENCCGVE
AqueK158_Aque K---THPNIVSFFELNEI-----E---KKHQYHIIAMELCNGGSLYE-VIDSPQNAYGLD
::: : :* * *.: :. * *:
TBK1_Hsap ESEFLIVLRDVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD
IKKe_Hsap EDEFLVVLRCVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDD
IKKb_Hsap EGAILTLLSDIASALRYLHE-NRIIHRDLKPENIVLQQG-EQRLIHKIIDLGYAKELDQG
IKKa_Hsap ESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQDV-GGKIIHKIIDLGYAKDVDQG
ird5_Dmel EFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQ
ik2_Dmel EHEFLLVLEHLCAGMKHLRD-NKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDN
IKKe_Mmus EEEFLVVLRCVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDD
IKKb_Mmus EGAVLTLLSDIASALRYLHE-NRIIHRDLKPENIVLQQG-EKRLIHKIIDLGYAKELDQG
IKKa_Mmus ESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQDV-GGKTIHKIIDLGYAKDVDQG
TBK1_Mmus ESEFLIVLRDVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD
TBK1_Spur EKEFLQVLNDVSAGMKHLRD-KGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDD
IKKe_Spur EKAFLQVLADMTAGMKYLRD-NGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDD
IKKa_Spur EAEILLLSKHIASAMEYLHK-SDIIHRDIKPENIMVQDW---------------------
AqueK157_Aque EKQFRKICGDINNGIRFLHK-ISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALS
AqueK158_Aque EYQFKSVIFDVASGMRHLRD-HGFVHRDIKPGNIMRCINPDGSFVFKLADFGTARQLDPN
* . : : .:..*:. . ***:** **:
TBK1_Hsap EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE-G
IKKe_Hsap EKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-G
IKKb_Hsap SLCTSFVGTLQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-Q
IKKa_Hsap SLCTSFVGTLQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-Q
ird5_Dmel TMVQSVVGTRHYYAPEVVEN--------GFYNSTVDLWSFGVIAYELVTGELPFIPHQ-T
ik2_Dmel QPFASLYGTEEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFG-G
IKKe_Mmus EKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-G
IKKb_Mmus SLCTSFVGTLQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-Q
IKKa_Mmus SLCTSFVGTLQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-Q
TBK1_Mmus EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFE-G
TBK1_Spur EAFKSLYGTEEYLHPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPFRA----
IKKe_Spur ENFTSLHGTEEYLHPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLP-------
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque SKAQSLVGTPQYVAPEIIDQ--------DSHGRPVDFWSFGVVAFELVTGIRPFLHKSRR
AqueK158_Aque EHFTSLHGTEEYLYPAMYERALINYRSKEEFLDKVDLWSLGATFFHLATGRLPF------
TBK1_Hsap PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILE
IKKe_Hsap PRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILE
IKKb_Hsap PVQW---HSKV-RQKSEVDIVVS-EDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLM
IKKa_Hsap PFTW---HEKI-KKKDPKCIFAC-EEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLN
ird5_Dmel LKNI---ILNL-IKKPAKCIAIT-EDPEDNTRFVN-------------------------
ik2_Dmel -RKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLE
IKKe_Mmus PRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQLVPILANILE
IKKb_Mmus PVQW---HSKV-RQKSEVDIVVS-EDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLM
IKKa_Mmus PFTW---HEKI-KKKDPKCIFAC-EEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLN
TBK1_Mmus PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILE
TBK1_Spur ------------------------------------------------------------
IKKe_Spur ------------------------------------------------------------
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque PLEW---IGPT-RNKRDNCIYIT-F-NNGQLEYYDSIPSPHQLSSAFAGELTKWLQVVLH
AqueK158_Aque ------------------------------------------------------------
TBK1_Hsap ADQEKCWGFDQFFAE----------------------TSD
IKKe_Hsap VEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYI
IKKb_Hsap WHPR---------------------------------QRG
IKKa_Hsap WDPQ---------------------------------QRG
ird5_Dmel --------------------------------------QF
ik2_Dmel ENREKTWSFDRFFHE----------------------VTL
IKKe_Mmus VEEDKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYI
IKKb_Mmus WHPR---------------------------------QRG
IKKa_Mmus WDPQ---------------------------------QRG
TBK1_Mmus ADQEKCWGFDQFFAE----------------------TSD
TBK1_Spur ---------------------------------------H
IKKe_Spur ---------------------------------------F
IKKa_Spur ---------------------------------------K
AqueK157_Aque QESE---------------------------------KRG
AqueK158_Aque ----------------------------------------