TBK1_Hsap MQ-------------------------------------------STSNHLWLLSDILGQ
IKKe_Hsap MQ-------------------------------------------STANYLWHTDDLLGQ
IKKb_Hsap MSWSP-------------------------------------SLTTQTCGAWEMKERLGT
IKKa_Hsap MERPP-------------------------------------GLRPGAGGPWEMRERLGT
ird5_Dmel MITVVFCFSDCHGGIQILGRMSSVN-K----------IKLNENNKMHSFGNWERCRNLGE
ik2_Dmel MSF----------------------------------------LRGSVSYVWCTTSVLGK
IKKe_Mmus MQ-------------------------------------------STTNYLWHTDDLLGQ
IKKb_Mmus MSWSP-------------------------------------SLPTQTCGAWEMKERLGT
IKKa_Mmus MERPP-------------------------------------GLRPGAGGPWEMRERLGT
TBK1_Mmus MQ-------------------------------------------STSNHLWLLSDILGQ
TBK1_Spur MAATQG-------------------------------------IRSTKTYIWYLKDVLGT
IKKe_Spur MSDKDH-I------------QGWSRNFVEVMEQNGRARQPVPNIRSTPGYIIFLDTPLGQ
IKKa_Spur MP-------------------------------------------SPSGDQWQFKKLLGS
AqueK157_Aque MSIRK---------------------------------------------NWR-RAPIGR
AqueK158_Aque MAYNYQQV------------RPAFIGGG------------DETEYYSLSYIWSSKDKLGQ
* :*
TBK1_Hsap GATANVFRGR--------------------------------------------------
IKKe_Hsap GATASVYKAR--------------------------------------------------
IKKb_Hsap GGFGNVIRWH--------------------------------------------------
IKKa_Hsap GGFGNVCLYQ--------------------------------------------------
ird5_Dmel GGFGLVIHWR--------------------------------------------------
ik2_Dmel GATGSVFQGV--------------------------------------------------
IKKe_Mmus GATASVYKAR--------------------------------------------------
IKKb_Mmus GGFGNVIRWH--------------------------------------------------
IKKa_Mmus GGFGNVSLYQ--------------------------------------------------
TBK1_Mmus GATANVFRGR--------------------------------------------------
TBK1_Spur GATSSVYLGR--------------------------------------------------
IKKe_Spur GATSKVYGGR--------------------------------------------------
IKKa_Spur GSFGEVLLYQLGVGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCGVWLASLWCLVGVV
AqueK157_Aque GSFGDVSLFT--------------------------------------------------
AqueK158_Aque GATGQVFAGY--------------------------------------------------
*. . *
TBK1_Hsap ------------------------------------------------------------
IKKe_Hsap ------------------------------------------------------------
IKKb_Hsap ------------------------------------------------------------
IKKa_Hsap ------------------------------------------------------------
ird5_Dmel ------------------------------------------------------------
ik2_Dmel ------------------------------------------------------------
IKKe_Mmus ------------------------------------------------------------
IKKb_Mmus ------------------------------------------------------------
IKKa_Mmus ------------------------------------------------------------
TBK1_Mmus ------------------------------------------------------------
TBK1_Spur ------------------------------------------------------------
IKKe_Spur ------------------------------------------------------------
IKKa_Spur VVSGWRRCGVGLVSMSSQFGVDANVGLASMWCHFGLVCGVDEESVCPRCGVGLVLMWSQF
AqueK157_Aque ------------------------------------------------------------
AqueK158_Aque ------------------------------------------------------------
TBK1_Hsap ----------HKKTGDLFAIKVFNNISFLRPVD---------VQMREFEVLKKL-NHKNI
IKKe_Hsap ----------NKKSGELVAVKVFNTTSYLRPRE---------VQVREFEVLRKL-NHQNI
IKKb_Hsap ----------NQETGEQIAIKQCRQELSPRNRE---------RWCLEIQIMRRL-THPNV
IKKa_Hsap ----------HRELDLKIAIKSCRLELSTKNRE---------RWCHEIQIMKKL-NHANV
ird5_Dmel ----------NRTTGREIATKHIKEMGALS-ADQQVK--LSERWNKELNWSRQFKNFPHI
ik2_Dmel ----------NKITGESVAVKTFNPYSHMRPAD---------VQMREFEALKKV-NHENI
IKKe_Mmus ----------NKKSGEVVAVKVFNSASYRRPPE---------VQVREFEVLRRL-NHQNI
IKKb_Mmus ----------NQATGEQIAIKQCRQELSPKNRD---------RWCLEIQIMRRL-NHPNV
IKKa_Mmus ----------HRELDLKIAIKSCRLELSSKNRE---------RWCHEIQIMKKL-DHANV
TBK1_Mmus ----------HKKTGDLYAVKVFNNISFLRPVD---------VQMREFEVLKKL-NHKNI
TBK1_Spur ----------HKKNGDVVAVKMFNHLSYMRPRD---------VQQREFEVLLKL-NHKNI
IKKe_Spur ----------HKKLGKRVACKVPHTANLFRMGT---------DMERESQVLLRL-RNQNI
IKKa_Spur GVDVVSVRRQCGETSEYIALKRCKSILQLE---------NLKRWRDEVEFMRNL-EHPNI
AqueK157_Aque -----------SNDGEQIALKEMKLE-PLRNLDSHERDKMIVRLRNEIKIMWEH-NHPNL
AqueK158_Aque ----------SKRSGDKVAIKMFTSPSEYKAMQ---------SEMQTIKALK---THPNI
. * * : ::
TBK1_Hsap VKLFAIEEE---------TTTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLPESEFLIVLR
IKKe_Hsap VKLFAVEET---------GGSRQKVLVMEYCSSGSLLS-VLESPENAFGLPEDEFLVVLR
IKKb_Hsap VAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRK-YLNQFENCCGLREGAILTLLS
IKKa_Hsap VKACDVPEE-----LNI-LIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLS
ird5_Dmel VAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRK-RLQSPENANGLTEFEVRQILG
ik2_Dmel VKLLAIEED---------QEGRGKVIVMELCTGGSLFN-ILDDPENSYGLPEHEFLLVLE
IKKe_Mmus VKLFAVEET---------GGSRQKVLIMEYCSSGSLLS-VLEDPENTFGLSEEEFLVVLR
IKKb_Mmus VAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRR-YLNQFENCCGLREGAVLTLLS
IKKa_Mmus VKACDVPEE-----LNF-LINDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLS
TBK1_Mmus VKLFAIEEE---------TTTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLPESEFLIVLR
TBK1_Spur IHLDQIEED---------QISKQPVIVMELCTGGSLYT-YLDTPENLYGLKEKEFLQVLN
IKKe_Spur VCLEAIEKD---------QISKENILIMELCTGGSLYD-VLEKPENSCGLAEKAFLQVLA
IKKa_Spur VQGRPVPPE-----L-EAKPNEPPCLAMEFCSRGDLRK-KLSELPNMCGLPEAEILLLSK
AqueK157_Aque IKALGPPPD-----IPYHPPEDVMHVWMEFCNGGDLRNGVLKKIENCCGVEEKQFRKICG
AqueK158_Aque VSFFELNEI-----E---KKHQYHIIAMELCNGGSLYE-VIDSPQNAYGLDEYQFKSVIF
: : :* * *.: :. * *: * . :
TBK1_Hsap DVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT
IKKe_Hsap CVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGT
IKKb_Hsap DIASALRYLHE-NRIIHRDLKPENIVLQQGE-QRLIHKIIDLGYAKELDQGSLCTSFVGT
IKKa_Hsap DIGSGIRYLHE-NKIIHRDLKPENIVLQDVG-GKIIHKIIDLGYAKDVDQGSLCTSFVGT
ird5_Dmel ALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGT
ik2_Dmel HLCAGMKHLRD-NKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGT
IKKe_Mmus CVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGT
IKKb_Mmus DIASALRYLHE-NRIIHRDLKPENIVLQQGE-KRLIHKIIDLGYAKELDQGSLCTSFVGT
IKKa_Mmus DIGSGIRYLHE-NKIIHRDLKPENIVLQDVG-GKTIHKIIDLGYAKDVDQGSLCTSFVGT
TBK1_Mmus DVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT
TBK1_Spur DVSAGMKHLRD-KGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDDEAFKSLYGT
IKKe_Spur DMTAGMKYLRD-NGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDDENFTSLHGT
IKKa_Spur HIASAMEYLHK-SDIIHRDIKPENIMVQD-WKGQC----------------------HGT
AqueK157_Aque DINNGIRFLHK-ISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALSSKAQSLVGT
AqueK158_Aque DVASGMRHLRD-HGFVHRDIKPGNIMRCINPDGSFVFKLADFGTARQLDPNEHFTSLHGT
: .:..*:. . ***:** **: **
TBK1_Hsap EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE-GPRRNKEVMY
IKKe_Hsap EEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-GPRRNKEIMY
IKKb_Hsap LQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-QPV---QWHS
IKKa_Hsap LQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-QPF---TWHE
ird5_Dmel RHYYAPEVVEN--------GFYNSTVDLWSFGVIAYELVTGELPFIPHQ-TLK---NIIL
ik2_Dmel EEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFG-G-RKNRETMH
IKKe_Mmus EEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-GPRRNKEIMY
IKKb_Mmus LQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-QPV---QWHS
IKKa_Mmus LQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-QPF---TWHE
TBK1_Mmus EEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFE-GPRRNKEVMY
TBK1_Spur EEYLHPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPFRAHG-G-RNNRDVMH
IKKe_Spur EEYLHPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLPFRPHG-G-RKNSRMMF
IKKa_Spur TQ----------------------TVDLVI------------------------------
AqueK157_Aque PQYVAPEIIDQ--------DSHGRPVDFWSFGVVAFELVTGIRPFLHKSRRPL---EWIG
AqueK158_Aque EEYLYPAMYERALINYRSKEEFLDKVDLWSLGATFFHLATGRLPFRPYR-K-RQDRGTMF
. *
TBK1_Hsap KIITGKPSGAISGVQK-AE--NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQE--
IKKe_Hsap RITTEKPAGAIAGAQR-RE--NGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQA--
IKKb_Hsap KV-RQKSEVDIVVS-E-DL--NGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQR
IKKa_Hsap KI-KKKDPKCIFAC-E-EM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQR
ird5_Dmel NL-IKKPAKCIAIT-E-DPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKER
ik2_Dmel QITTKKASGVISGTQL-SE--NGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENRE--
IKKe_Mmus RITTEKPAGAISGTQK-QE--NGPLEWSYSLPITCRLSMGLQNQLVPILANILEVEED--
IKKb_Mmus KV-RQKSEVDIVVS-E-DL--NGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQR
IKKa_Mmus KI-KKKDPKCIFAC-E-EM--TGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQR
TBK1_Mmus KIITGKPSGAISGVQK-AE--NGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQE--
TBK1_Spur RITTTKKSSMISGVQE-VP--NGPIIWSEDLPKTCHFSPDMRHQVKTLLSHTMECNIQ--
IKKe_Spur HLTTKKAPGVISGVQTGPL--DHEITWSRELPETCRLSIGLKKLITPLLAGLLESNPS--
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque PT-RNKRDNCIYIT---FN--NGQLEYYDSIPSPHQLSSAFAGELTKWLQVVLHQESEKR
AqueK158_Aque KIINEKKTGIILGWQQ-EY--NAPIYYSDRLPPDIVISQGLRDIITPILAGVLDTF-D--
TBK1_Hsap -----KCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY---NTATIFHELVYKQ
IKKe_Hsap -----KCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAH---NTIAIFQEAVHKQ
IKKb_Hsap G--TDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTED---ESLQSLKARIQQD
IKKa_Hsap GGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPD---ESLHSLQSRIERE
ird5_Dmel G--QLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAE---MTMKDLIALIVLD
ik2_Dmel -----KTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVFLEPD---EQIDNFRERIFLQ
IKKe_Mmus -----KCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYIHAH---NTIAIFLEAVYEQ
IKKb_Mmus G--TDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTED---ESLQSLKTRIQED
IKKa_Mmus GGPIDLTLKQPRCFALMDHILNLKIVHILNMTSAKIISFLLPCD---ESLHSLQSRIERE
TBK1_Mmus -----KCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSY---NTAAVFHELVYKQ
TBK1_Spur -----KMWTFDIFFDFVQRLTSMRPVDVFVAPTCECHIVYVEPQ---RKVADFQDKMAHL
IKKe_Spur -----TVWSFQHFFQASQAITTKIAIDVFWVCEASYMKIYCSPT---DRFAEFQENIASQ
IKKa_Spur ---------------------------------HSPVTYPLDHD---TS-----------
AqueK157_Aque G--VAHNGDEAPCLLHIDRILRTKVLIIVSMSNGHVLSYSVRCD---SSYQSLSAWLE-E
AqueK158_Aque -----SMWAFDRFFKAIDGIKKQNVVHIFCVSRCTCHMIYVDDAGEADIIPKFKELIARQ
TBK1_Hsap TKIISSNQELIYEGRRLVLEPGRLAQH-FPKTTEENPI---------FVVSREPL--NTI
IKKe_Hsap TSVAPRHQEYLFEGHLCVLEPSVSAQH-IAHTTASSPL---------TLFSTAI--PKGL
IKKb_Hsap TGIPEEDQELLQEAGL-ALIPDKPATQCISDGKLNEGHTLDM--DLVFLFDNSKITYET-
IKKa_Hsap TGINTGSQELLSETGI-SLDPRKPASQCVLDGVR----GCDS--YMVYLFDKSKTVYEG-
ird5_Dmel TGMDEKELYFVLPTSH---------PHK-TITPKSTPLQL----YVEEWSDTSKDS--R-
ik2_Dmel TEVPLEKQILLFNNEHLE--KKV-----TPR-TIDQPI---------FLYSNDDNNV-QL
IKKe_Mmus TNVTPKHQEYLFEGHPCVLEPSLSAQH-IAHTAASSPL---------TLFSMSSDTPKGL
IKKb_Mmus TGILETDQELLQEAGL-VLLPDKPATQCISDSKTNEGLTLDM--DLVFLFDNSKINYET-
IKKa_Mmus TGINTGSQELLSETGI-SLDPRKPASQCVLDGVR----GCDS--YMVYLFDKSKTVYEG-
TBK1_Mmus TKIVSSNQELIYEGRRLVLELGRLAQH-FPKTTEENPI---------FVTSREQL--NTV
TBK1_Spur TGIQPETQSLLWDKEVFDLKKCLKCED-LPQTSPDNPL---------ILVRMGAEVF--P
IKKe_Spur TKLSATKQSILYNGETFKPDGILPISS-YPITSVANPI---------TLSNKEQIHV-QH
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque KGYPKSKQYLVTDRGE-LLSDSLLDLH-S-------SLRWDDCICTVYLFSQDVV-PSF-
AqueK158_Aque TSLDPKHMEMYLENILFGTEPVR-ARD-LPLTTPDSPL---------TVFGGPPQKP--D
TBK1_Hsap GLIYEK-ISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLY----QELMRKGIRW
IKKe_Hsap AFRDPA-LDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDG----QELMFRGLHW
IKKb_Hsap QISPRPQPESVSCILQE-----PKRNLAFF--------------------QLRKVWGQVW
IKKa_Hsap PFASRSLSDCVNYIVQD-----SKIQLPII--------------------QLRKVWAEAV
ird5_Dmel KWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKF-IANKFKTKERWLQKRVVLDMLY
ik2_Dmel PQQLDL-PKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSM----DILIKKGVEH
IKKe_Mmus AFRDPA-LDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDG----QALMLRGLHW
IKKb_Mmus QITPRPQPESVSCILQE-----PKRNLSFF--------------------QLRKVWGQVW
IKKa_Mmus PFASRSLSDCVNYIVQD-----SKIQLPII--------------------QLRKVWAEAV
TBK1_Mmus GLRYEK-ISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLY----QELMRKGVRW
TBK1_Spur SVKVPSLPTQPKTATHFSVQQDSTLAKHIFTVVL--------------------------
IKKe_Spur QLTPPFVATMPALRPRFSTQNDYPIAKGALATGCILQTRQKMIHEM----HGLFDQYVIT
IKKa_Spur --------------------ND--------------------------------------
AqueK157_Aque KLVVQVTP-SVTNLITN-----GDENLHRE--------------------DKYMHFAHAY
AqueK158_Aque KLATPVVTQPPNMPPETTMVDDLRYAKDCTKAIWVMYRAAETMDRY----FRLMNQGALC
TBK1_Hsap -LIELIKDDYNETVHKKTEVV---ITLD-----------------FCIR-----------
IKKe_Hsap -VMEVLQATCRRTLEVARTSL---LYLS-----------------SSLG-----------
IKKb_Hsap HSIQTLKEDCNRLQQGQRAAM---MNLL-------------RNN-SCLSKMKNSMASMSQ
IKKa_Hsap HYVSGLKEDYSRLFQGQRAAM---LSLL-------------RYN-ANLTKMKNTLISASQ
ird5_Dmel V-LTKEQARYEMLVSGINERA---LSLEDEMMENSFIDSIDKQR-IIISFAYDQLTSLLK
ik2_Dmel -FIEMLVTTITLLLKKTESFD---NLLS-----------------TVID-----------
IKKe_Mmus -VLEVLQDTCQQTLEVTRTAL---LYLS-----------------SSLG-----------
IKKb_Mmus HSIQTLKEDCNRLQQGQRAAM---MSLL-------------RNN-SCLSKMKNAMASTAQ
IKKa_Mmus HYVSGLKEDYSRLFQGQRAAM---LSLL-------------RYN-ANLTKMKNTLISASQ
TBK1_Mmus -LVELVKDDYNETVHKKTEVV---ITLD-----------------FCIR-----------
TBK1_Spur ------RMDYMKLRSEHSAVKSFCLQAD-----------------CRWR-----------
IKKe_Spur -LRDRSKMDVLRLQDHHKLVKGKLSIMS-----------------THLG-----------
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque SHIKDQERLFWRIHNGHRA-I---LQLI-------------RPVTEELKGHYDDHSTEVA
AqueK158_Aque -LRETLDKDYRAWCRKYEEVQ---VRFN-----------------SL-------------
TBK1_Hsap -----------NIEKTVKVYEKLM----------K---INLEAAE-L---GEISDIHT--
IKKe_Hsap ----------------TERFSSVA--GTPEI---Q---ELKAAAE-L--RSRLRTLAE--
IKKb_Hsap QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVE--
IKKa_Hsap QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLED--
ird5_Dmel EAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFL------EACLREA--KDMVK--
ik2_Dmel ------------YADVVHSMARVT----------K------G-------DQEIKTLLT--
IKKe_Mmus ----------------TERFSSGA--GMPDV---Q---ERKEATE-L--RTRLQTLSE--
IKKb_Mmus QLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVE--
IKKa_Mmus QLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLED--
TBK1_Mmus -----------NIEKTVKVYEKLM----------K---VNLEAAE-L---GEISDIHT--
TBK1_Spur -----------ALERSLT------------------------------------------
IKKe_Spur -----------DGK-------RIL--NL------------LRNTQ-E---GRISDITH--
IKKa_Spur ---------------------------------------------TCIYK----------
AqueK157_Aque KCLGVANFMKKMYSEDMEKLSDN--------SRINAWRSELS------------------
AqueK158_Aque -----------------------I--DI------------SNSQI-V---GLQSDVEFLQ
TBK1_Hsap K-----L-----LRLSSSQG---------------------TIETSLQDIDSRLSPGGS-
IKKe_Hsap V-----L-----SRCSQNIT---------------------ETQESLSSLNREL------
IKKb_Hsap R-----M-----MALQTDIVDLQRSPM---------------------------------
IKKa_Hsap Q-----I-----MSLHAEIMELQKSPY---------------------------------
ird5_Dmel TTNQLRK-----EVCEKDLFDCARFYK---------------------------------
ik2_Dmel A-----L-----ENVKSDFD---------------------GAADVISQMHKHFVIDDE-
IKKe_Mmus I-----L-----SKCSHNVT---------------------ETQRSLSCLGEEL------
IKKb_Mmus R-----M-----MALQTDIVDLQRSPM---------------------------------
IKKa_Mmus Q-----I-----MSLHTEIMELQKSPY---------------------------------
TBK1_Mmus K-----L-----LRLSSSQG---------------------TIESSLQDISSRLSPGGL-
TBK1_Spur -------------LVLTGVD-----------------------GASLDEIKLRII-----
IKKe_Spur --------------------QLERKLEEGSHDLMQFEMQSNEIDEILNQLHTDVFINDI-
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque ------------------------------------------------------------
AqueK158_Aque A-----INPLCNNAFDHDIADLQRQLEDKNKHLVDVRDQSFALHEQTKDFHSTVN--SIT
TBK1_Hsap LADAWA---HQEGTHPKD-RNVEKL---QVLLNCMTEIYYQFKKDKAERRLAYN--EEQI
IKKe_Hsap ----VK---SRDQVHED--RSIQQI---QCCLDKMNFIYKQFKKSRMRPGLGYN--EEQI
IKKb_Hsap ----------------GR-KQGGTL---DDLEEQARELYRRLREKPRDQRTEG-DSQEMV
IKKa_Hsap ----------------GR-RQGDLM---ESLEQRAIDLYKQLKHRPSDHS-YS-DSTEMV
ird5_Dmel ----------------KY-LCNGAIISPSELNNDAE----EFAKSRF-KL----YNEGEA
ik2_Dmel LNDQWTSSMHGKKCPCKT-RASAQA---KYLVERLRDSWQHLLRDRATRTLTYN--DEQF
IKKe_Mmus ----LK---NRDQIHEDN-KSIQKI---QCCLDKMHFIYKQFKKSRMRPGLSYN--EEQI
IKKb_Mmus ----------------GR-KQGGTL---DDLEEQARELYRRLREKPRDQRTEG-DSQEMV
IKKa_Mmus ----------------GR-RQGDLM---ESLEQRAIDLYKQLKHRPPDHL-YS-DSTEMV
TBK1_Mmus LADTWA---HQEGTHPRD-RNVEKL---QVLLNCITEIYYQFKKDKAERRLAYN--EEQI
TBK1_Spur -----K---CKERLYE--------V---QNVF---HSIFYV-------------------
IKKe_Spur LQSIWKP---SQGCNVQDEKCSTEL---VHLTDEMEDIFKRFSRDKKTGKLSYN--EEQI
IKKa_Spur ------------------------------L-----------------------------
AqueK157_Aque ------------------------------------------------------------
AqueK158_Aque SSSIWDT---NYLAKVFN-ESTKTM---MSYVDKVEEIFNAFQEQKKQRGAIHGDYDRRS
TBK1_Hsap HKFDKQKLYY-----------------HATKAMTH--FTD---ECVKKY----EAFLN--
IKKe_Hsap HKLDKVNFSH-----------------LAKRLLQV--FQE---ECVQKY----QASLV--
IKKb_Hsap -RLLLQAIQS-----------------FEKKVRVIYTQLSKTVVCKQKA----LELLPKV
IKKa_Hsap -KIIVHTVQS-----------------QDRVLKELFGHLSKLLGCKQKI----IDLLPKV
ird5_Dmel -----------------------------RHLPKSIDHMHYLY-----------------
ik2_Dmel HALEKIKVDH-----------------NGKRIKAL--LLD---NVNPTV----AQIAE--
IKKe_Mmus HKLDKVNFSH-----------------LAKRLLQV--FQE---ECVQTY----QVSLV--
IKKb_Mmus -RLLLQAIQS-----------------FEKKVRVIYTQLSKTVVCKQKA----LELLPKV
IKKa_Mmus -KIIVHTVQS-----------------QDRVLKELFGHLSKLLGCKQKI----IDLLPKV
TBK1_Mmus HKFDKQKLYY-----------------HATKAMSH--FSE---ECVRKY----EAFKD--
TBK1_Spur ------------------------------------------------------------
IKKe_Spur HKMEKLSLGD-----------------LMKRTMTC---SG---GCEERWRSQHKLLMV--
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque ----------------------------------------------------------KL
AqueK158_Aque HEYNKRTIKERLGMADKKLSEMIAGRNHVYGNLYH--FLE---KCTP----VRE------
TBK1_Hsap -------KSEE-WIRK---MLHLRKQL-------LSL-------TNQCFD--IEEEVSKY
IKKe_Hsap -------THGK-RMRV---VHETRNHL-------RLV-------GCSVAA--CNTEAQGV
IKKb_Hsap EEVVSLMNEDEKTVVR-L-QEKRQKELW------NLL-------KIACSK--VRGPVSGS
IKKa_Hsap EVALSNIKEADNTVMF-M-QGKRQKEIW------HLL-------KIACTQSSARSLVGSS
ird5_Dmel --------------------FKTKESIP------VLL-------QQFCD---IKKEIFQI
ik2_Dmel -------CLAD-WYKLAQ-TVYLKTQI---------L-------EKDVRD--CERKLNGI
IKKe_Mmus -------THGK-RMRQ---VQRAQNHL-------HLI-------GHSVAT--CNSEARGA
IKKb_Mmus EEVVSLMNEDERTVVR-L-QEKRQKELW------NLL-------KIACSK--VRGPVSGS
IKKa_Mmus EVALSNIKEADNTVMF-M-QGKRQKEIW------HLL-------KIACTQSSARSLVGYS
TBK1_Mmus -------KSEE-WMRK---MLHLRKQL-------LSL-------TNQCFD--IEEEVSKY
TBK1_Spur -----------------------------------------------------EK-----
IKKe_Spur -------CHNK-AYNQRQQLLKADRSLAPLVHHCNVLENTISDLHSQCWQ--IAESKTPP
IKKa_Spur -----------------------------------------------AN---WEREILKF
AqueK157_Aque D-----------------------------------------------------------
AqueK158_Aque ------------------DLRNLMASLDHSAQCT---KEDTIRLQ---------KWLPHH
TBK1_Hsap QEYT---NELQETLPQKMFTA-SSGIKHTMTP----------------------------
IKKe_Hsap QESL---SKLLEELSHQLLQDRAKGAQASPPP----------------------------
IKKb_Hsap PDSM---NASRLSQPGQLMSQ-PSTASNSL------------------------------
IKKa_Hsap LEGAVTPQTSAWLPPTSAEHD-HSLSCVVT------------------------------
ird5_Dmel NLQML--MSASSTPPPKLE-----------------------------------------
ik2_Dmel RDEL---YHVKSELKLDVDTK-TINNNNQLAK----------------------------
IKKe_Mmus QESL---NKIFDQLLLDR--ASEQGAEVSPQP----------------------------
IKKb_Mmus PDSM---NVSRLSHPGQLMSQ-PSSACDSL------------------------------
IKKa_Mmus LEGTVTPPVSAWLPPTLADRE-HPLTCVVT------------------------------
TBK1_Mmus QDYT---NELQETLPQKMLAA-SGGVKHAMAP----------------------------
TBK1_Spur ------------------------------------------------------------
IKKe_Spur PDMK---RHHTYQAPKEILL-SASTQ-TSLPKEETPSHHTSLLLDHHYDQLTKGGKPLVM
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque ------------------------QAIKVH------------------------------
AqueK158_Aque QQRM---QNLLGKLPNSL-S-GGGG------------------------------GGGGM
TBK1_Hsap -----------------------IYP-------------------------S-SNTLVE-
IKKe_Hsap -----------------------IAP-------------------------YPSPTRKD-
IKKb_Hsap -------------------------P-------------------------EPAKKSEE-
IKKa_Hsap -------------------------P-------------------------QDGETSAQ-
ird5_Dmel ------------------------------------------------------------
ik2_Dmel ---------------------------------------------------------IE-
IKKe_Mmus -----------------------MAP-------------------------HPGPDPKD-
IKKb_Mmus -------------------------P-------------------------ESDKKSEE-
IKKa_Mmus -------------------------P-------------------------QDGETLAQ-
TBK1_Mmus -----------------------IYP-------------------------S-SNTLVE-
TBK1_Spur ------------------------------------------------------------
IKKe_Spur GKSTINSQRSPYSVDRSTGQYPELYQTASALSEPSCGTSQYRYDAPLTRARSSPPELVAR
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque -------------------------P-------------------------HSSAIST--
AqueK158_Aque GTLQLN------------------------------------------------------
TBK1_Hsap -------------------------------------------MTLGMKKLKE-------
IKKe_Hsap -------------------------------------------LLLHMQELCE-------
IKKb_Hsap -------------------------------------------LVAEAHNLCT---LLEN
IKKa_Hsap -------------------------------------------MIEENLNCLG---HLST
ird5_Dmel -------------------------------------------LSAAMDRLAISSGSPSS
ik2_Dmel -------------------------------------------ERNRLRVMQQ-------
IKKe_Mmus -------------------------------------------LVFHMQELCN-------
IKKb_Mmus -------------------------------------------LVAEAHALCS---RLES
IKKa_Mmus -------------------------------------------MIEENLNCLG---HLST
TBK1_Mmus -------------------------------------------MTLGMKKLKE-------
TBK1_Spur ------------------------------------------------------------
IKKe_Spur GISRRSPDAPSELYGVDPTPGAIGGLQDLRSPAGDYQQAEGPRMIKVSKEFKK-------
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque -------------------------------------------HTHTHTHTCR---TFIH
AqueK158_Aque ------------------------------------------------------------
TBK1_Hsap EMEGVVKELAENNHI-------------------------------LERFGSLTMD----
IKKe_Hsap GMKLLASDLLDNNRI-------------------------------IERLNRV-------
IKKb_Hsap AIQDTVREQDQSFTA-------------------------------LDW-SWLQTEE---
IKKa_Hsap IIHEANEEQGNSMMN-------------------------------LDW-----------
ird5_Dmel DPFDS-----------------------------------------------LRTIN---
ik2_Dmel QQQEVMAVMRTNSDI-------------------------------ISLLSKLGIT----
IKKe_Mmus DMKLLAFDLQDNNRL-------------------------------IERLHRV-------
IKKb_Mmus ALQDTVKEQDRSFTT-------------------------------LDW-SWLQMED---
IKKa_Mmus IIREANEDQSSSLMS-------------------------------LDW-----------
TBK1_Mmus EMEGVVKELAENNHI-------------------------------LERFGSLTMD----
TBK1_Spur ------------------------------------------------KF--LKE-----
IKKe_Spur RVADYRKESNTSYHIQRNLAELTQLELESMSLETPEMPRYTADSSLLDTLTGPGMDEGDE
IKKa_Spur ------------------------------------------------------------
AqueK157_Aque ----------------------------------------------------LLL-R---
AqueK158_Aque -----------------SLRSLLQRAREST----GDLL------KLADKQ----------
TBK1_Hsap ----------GGLRNVDCL
IKKe_Hsap -------------PAPPDV
IKKb_Hsap --------EEH-SCLEQAS
IKKa_Hsap --------------SWLTE
ird5_Dmel --------AIEEAERINNM
ik2_Dmel ----------N--GSLESS
IKKe_Mmus -------------PSAPDV
IKKb_Mmus --------EERCSLEQACD
IKKa_Mmus --------------SWLAE
TBK1_Mmus ----------GGLRNVDCL
TBK1_Spur ----------EG-SHMLLN
IKKe_Spur SILEGLDIKRPPVSYQSGT
IKKa_Spur ----------MGSMYNARL
AqueK157_Aque --------CMHFPKRLERS
AqueK158_Aque KTL-----IHPPSDKKEKS