IRR_Hsap        ISIIRELGQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASPRECIEFLKEASVMK
INSR_Hsap       ITLLRELGQGSFGMVYEGNARDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMK
IGF1R_Hsap      ITMSRELGQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMK
InR_Dmel        IIQLAPLGQGSFGMVYEGILKSFPP--NGV-DRECAIKTVNENATDRERTNFLSEASVMK
IRR_Mmus        IAIIRELGQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASARERVEFLKEASVMK
INSR_Mmus       ITLLRELGQGSFGMVYEGNAKDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMK
IGF1R_Mmus      ITMNRELGQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMK
daf-2_Cele      VVLGQQCGEGSFGKVYLGTGNNVVSLMGDR-FGPCAIKINVDDPASTENLNYLMEANIMK
ILGFR_Spur      VVLNRKLGEGAFGTVYGGEA--LLD--DNK-WAAVAVKTLKLGASVEEKLDFLSEAEVMK
InsRL_Spur      LEIIRELGKGSFGMVYEGLAKGILP--EEEEISRVAIKSVQANASMRDRIEFLNEASVMK
                :      *:*:** ** *    .            *:*     .:  :  ::* **.:**

IRR_Hsap        AFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPG-----------
INSR_Hsap       GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE-NNPG-----------
IGF1R_Hsap      EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME-NNPV-----------
InR_Dmel        EFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEER-DEAMMTYLNRIGVTG
IRR_Mmus        AFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPG-----------
INSR_Mmus       GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAE-NNPG-----------
IGF1R_Mmus      EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLV-----------
daf-2_Cele      NFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVF-NETDC--------N
ILGFR_Spur      RFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGE-GVYER--------N
InsRL_Spur      LIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQ-QDLPLI--------D
                 :    :*.* ** :  :*  .:**:*  *:*:  * . *

IRR_Hsap        -LPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE
INSR_Hsap       -RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE
IGF1R_Hsap      -LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE
InR_Dmel        NVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYE
IRR_Mmus        -LPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE
INSR_Mmus       -RPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE
IGF1R_Mmus      -LIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE
daf-2_Cele      FFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY
ILGFR_Spur      Q-HVMCPDQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRALYD
InsRL_Spur      RKSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQ
                         : . . :*..*:::* : :: ****:.***::  . * *:.***::* ::

IRR_Hsap        TDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVL
INSR_Hsap       TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL
IGF1R_Hsap      TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL
InR_Dmel        TDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVL
IRR_Mmus        TDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVL
INSR_Mmus       TDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVL
IGF1R_Mmus      TDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVL
daf-2_Cele      HDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVL
ILGFR_Spur      SDYYRLGKRSKLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNAEVL
InsRL_Spur      SDYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAG
                 ***:      :*:***.***: :* : : **::*:*::::*:.::.  **  *** :.

IRR_Hsap        KFV-MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ---------E
INSR_Hsap       KFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNL-----------L
IGF1R_Hsap      RFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK---------E
InR_Dmel        RYV-IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAY-----------L
IRR_Mmus        KFV-MDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQ---------D
INSR_Mmus       KFV-MDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNL-----------L
IGF1R_Mmus      RFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIK---------D
daf-2_Cele      NYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHL-----------L
ILGFR_Spur      DYI-RNRNSLRPPEGCSPALGALMMQCWAIQPQHRPTAKDVNDILCQRPHLITPCL
InsRL_Spur      EYI-KGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDYGLLRDSFA
                 ::      :   : *      :*  **      **   .: