IRR_Hsap MAVPS-------------------------------------------------------
INSR_Hsap MATGGR------------------------------------------------------
IGF1R_Hsap MKSGSG------------------------------------------------------
InR_Dmel MFNMPR---------------GVTKSKSKRGKIKMENDMAAAATTTACTLGHICVLCRQE
IRR_Mmus MAVPA-------------------------------------------------------
INSR_Mmus MGFGRG------------------------------------------------------
IGF1R_Mmus MKSGSG------------------------------------------------------
daf-2_Cele MNIVRCRRRHKILENLEEENLG-----PS------------CSSTTST---------T--
ILGFR_Spur MVGVAW------------------------------------------------------
InsRL_Spur MSD---------------------------------------------------------
*
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------------------------------
InR_Dmel MLLDTCCCRQAVEAVDSPA--------SSEEAYSSSNSSSCQASSEISAEEVWFLSHDDI
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------------------------------
daf-2_Cele ---------AATE-----ALGTTTEDMRLKQQ-----RSS--------------------
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------------------------------
InR_Dmel VLCRRPKFDEVETTGKKRDVKCSGHQCSNECDDGSTKNNRQQRENFNIFSNCHNILRTLQ
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------------------------------
daf-2_Cele ---------S--RATEHDIVD---------------------------------------
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------------------------------
InR_Dmel SLLLLMFNCGIFNKRRRRQHQQQHHHHYQHHHQQHHQQHHQRQQANVSYTKFLLLLQTLA
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------------------------------
daf-2_Cele ----------------------------GNHHDDEHITMRR--------LRL--------
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap -----------------------------------------------------------L
INSR_Hsap -------------------------------------------------------RGAAA
IGF1R_Hsap -------------------------------------------------------GGSPT
InR_Dmel AATTRLSLSPKNYKQQQQLQHNQQLPRATPQQ----KQQEKDRH-KCFHYKHNYSYSPGI
IRR_Mmus -----------------------------------------------------------L
INSR_Mmus -------------------------------------------------------CETTA
IGF1R_Mmus -------------------------------------------------------GGSPT
daf-2_Cele ------------------VKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMT
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap WPWGACLPVIFLSLGFGL------------------------------------------
INSR_Hsap APLLVAVAALLLGAAGHL------------------------------------------
IGF1R_Hsap SLW----GLLFLSAALSLW-----------------------------------------
InR_Dmel SLL----LFILLANTLAIQAVVLPAHQQHLLHNDIADGLDKTALSVSGTQSRWTRSESNP
IRR_Mmus WPWGVHLLMSLLSLGSGL------------------------------------------
INSR_Mmus VPLLVAVAALLVGTAGHL------------------------------------------
IGF1R_Mmus SLW----GLVFLSAALSLW-----------------------------------------
daf-2_Cele SLM----LLLLFAFVQPCA-----------------------------------------
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap -----DTVEVC-PSLDIRSEVAEL-----------------RQLENCSVVEGHLQILLMF
INSR_Hsap -----YPGEVC-PGMDIRNNLTRL-----------------HELENCSVIEGHLQILLMF
IGF1R_Hsap ----PTSGEICGPGIDIRNDYQQL-----------------KRLENCTVIEGYLHILLIS
InR_Dmel TMRLSQNVKPC-KSMDIRNMVSHF-----------------NQLENCTVIEGFLLIDLIN
IRR_Mmus -----DTLEVC-PSLDIRSEVTEL-----------------RRLENCSVVEGHLQILLMF
INSR_Mmus -----YPGEVC-PGMDIRNNLTRL-----------------HELENCSVIEGHLQILLMF
IGF1R_Mmus ----PTSGEICGPGIDIRNDYQQL-----------------KRLENCTVIEGFLHILLIS
daf-2_Cele ----SIVEKRC-GPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVL
ILGFR_Spur ------------IGPNLKSTVQQR-----------------QEKNQPT---------LFF
InsRL_Spur ------------------------------------------------------------
IRR_Hsap TATGE----D----------FRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGT
INSR_Hsap KTRPE----D----------FRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGS
IGF1R_Hsap K--AE----D----------YRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGW
InR_Dmel DASP-----------------LNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGN
IRR_Mmus AATGE----D----------FRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGT
INSR_Mmus KTRPE----D----------FRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGS
IGF1R_Mmus K--AE----D----------YRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGW
daf-2_Cele KHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGR
ILGFR_Spur GWTPD----DLTSS----GAFSRVAFPS--------------------------------
InsRL_Spur --------------------FQAMDFHAMDLL----------------------------
*
IRR_Hsap RLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHI
INSR_Hsap RLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYI
IGF1R_Hsap KLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYI
InR_Dmel KLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLV
IRR_Mmus RLFLGYALIIFEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGTNHI
INSR_Mmus RLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYI
IGF1R_Mmus KLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYI
daf-2_Cele SLIQHYALIIYRNPDL-EIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVV
ILGFR_Spur ------------------------------------------------------CQENAA
InsRL_Spur ----------------------QLLYRNRPDTRRRKKRDV--------------------
IRR_Hsap VGNKL---GEECA-DVCPGVLGAA---GEPCAKTTF-----SGHTD---------YRCWT
INSR_Hsap VLNKDD--NEECG-DICPGTAKG----KTNCPATVI-----NGQFV---------ERCWT
IGF1R_Hsap VGNKP---PKECG-DLCPGTMEE----KPMCEKTTI-----NNEYN---------YRCWT
InR_Dmel VLTENGK-EKECRLSKCPGEIRI----EEGHDTTAI-----EGELNASCQLHNNRRLCWN
IRR_Mmus VGNKL---GEECA-DVCPGVLGAA---GEPCSRTTF-----SGRTD---------YRCWT
INSR_Mmus VLNKDD--NEECG-DVCPGTAKG----KTNCPATVI-----NGQFV---------ERCWT
IGF1R_Mmus VGNKP---PKECG-DLCPGTLEE----KPMCEKTTI-----NNEYN---------YRCWT
daf-2_Cele VDNAAEYAVTETG-LMCPRGACEEDKGESKCHYLEEKNQEQGVERV---------QSCWS
ILGFR_Spur EDNPA---SLNCL-HVVPDVDGA-------------------------------------
InsRL_Spur -----------------PGSAI--------------------------------------
*
IRR_Hsap SSHCQRVC------PCPH-GMACTARGECCHTECLGGCSQPE-DPRACVACRHLYFQGAC
INSR_Hsap HSHCQKVC------PTICKSHGCTAEGLCCHSECLGNCSQPD-DPTKCVACRNFYLDGRC
IGF1R_Hsap TNRCQKMC------PSTCGKRACTENNECCHPECLGSCSAPD-NDTACVACRHYYYAGVC
InR_Dmel SKLCQTKC------PEKCR-NNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNIC
IRR_Mmus SSHCQKVC------PCPR-GMACTAGGDCCHSECLGGCSQPE-DPRACVACRHLYFQGVC
INSR_Mmus HSHCQKVC------PTICKSHGCTAEGLCCHKECLGNCSEPD-DPTKCVACRNFYLDGQC
IGF1R_Mmus TNRCQKMC------PSVCGKRACTENNECCHPECLGSCHTPD-DNTTCVACRHYYYKGVC
daf-2_Cele NTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVN-DATACHACKNVYHKGKC
ILGFR_Spur ----------------------------------TGGCDFPW-QNVNKVAWRPLVVGA--
InsRL_Spur ------------------------------------------------------------
IRR_Hsap LWACPPGTYQYESWRCVTAERCA------SLHSVPGRA-----STFGIHQGSCLAQCPSG
INSR_Hsap VETCPPPYYHFQDWRCVNFSFCQ------DLHHKCKNSRRQGCHQYVIHNNKCIPECPSG
IGF1R_Hsap VPACPPNTYRFEGWRCVDRDFCA------NILSAESSD----SEGFVIHDGECMQECPSG
InR_Dmel MDSCPKGYYQFDS-RCVTANECI------TLTKFETNS----VYSGIPYNGQCITHCPTG
IRR_Mmus LRACPPGTYQYESWRCVTAELCA------HLREVPGLA-----TTFGIYEGSCLAQCPPG
INSR_Mmus VETCPPPYYHFQDWRCVNFSFCQ------DLHFKCRNSRKPGCHQYVIHNNKCIPECPSG
IGF1R_Mmus VPACPPGTYRFEGWRCVDRDFCA------NIPNAESSD----SDGFVIHDDECMQECPSG
daf-2_Cele IEKCDAHLYLLLQRRCVTREQCL------QLNPVLSNK----TVPIKATAGLCSDKCPDG
ILGFR_Spur -------PYIYDLLKDVTFASSKMDGIMYSYYFSRLNMAEFACEWVQRNSGTWEPWIPSG
InsRL_Spur ------------------------------------------------------------
IRR_Hsap FTRNSS-SIFCHKCEG-LCPKECKV---GTKTIDSIQAAQDLVGCTHVEGS--LILNLRQ
INSR_Hsap YTMNSS-NLLCTPCLG-PCPKVCHL-LEGEKTIDSVTSAQELRGCTVINGS--LIINIRG
IGF1R_Hsap FIRNGSQSMYCIPCEG-PCPKVCEE-EKKTKTIDSVTSAQMLQGCTIFKGN--LLINIRR
InR_Dmel YQKSEN-KRMCEPCPGGKCDKECS-----SGLIDSLERAREFHGCTIITGTEPLTISIKR
IRR_Mmus FTRNGS-SIFCHKCEG-LCPKECKV---GTKTIDSVQATQDLVGCTHVEGN--LILNLRQ
INSR_Mmus YTMNSS-NLMCTPCLG-PCPKVCQI-LEGEKTIDSVTSAQELRGCTVINGS--LIINIRG
IGF1R_Mmus FIRNSTQSMYCIPCEG-PCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGN--LLINIRR
daf-2_Cele YQINPDDHRECRKCVG-KCEIVCEI----NHVIDTFPKAQAIRLCNIIDGN--LTIEIRG
ILGFR_Spur SAG---------------------------------------IKRTILLG--GLFETLID
InsRL_Spur ------------------------------------------------------------
IRR_Hsap --GYNLEPQLQHSLG-LVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVD-GNYTLYV
INSR_Hsap --GNNLAAELEANLG-LIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEI-GNYSFYA
IGF1R_Hsap --GNNIASELENFMG-LIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLE-GNYSFYV
InR_Dmel ESGAHVMDELKYGLA-AVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYV
IRR_Mmus --GYNLEPELQRNLG-LVETITGFLKIKHSFALVTLGFFKNLKLIRGDSMVD-GNYTLYV
INSR_Mmus --GNNLAAELEANLG-LIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEI-GNYSFYA
IGF1R_Mmus --GNNIASELENFMG-LIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLE-GNYSFYV
daf-2_Cele KQDSGMASELKDIFA-NIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFR-NLYAITV
ILGFR_Spur PT--SPNSGIEPGARMAIDAVNADLNILPNYKLTLASMETG---CSPETSL-LSYFKFYE
InsRL_Spur ------------------------------------------------------------
IRR_Hsap LDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGR-QNKAEINPRT
INSR_Hsap LDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR-QERNDIALKT
IGF1R_Hsap LDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR-QSKGDINTRN
InR_Dmel LDNRDLDELWGP-NQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADS
IRR_Mmus LDNQNLQQLGSWVTAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGTRGR-QSKAEINPRT
INSR_Mmus LDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR-QERNDIALKT
IGF1R_Mmus LDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGR-QSKGDINTRN
daf-2_Cele FENPNLKKLFDS-TTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNI--P-LDPIDQSEGT
ILGFR_Spur DRGQSLAGLVG-------------------PMCSSE------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap NGDRAACQTRTLRFVSNVTEADRILLRWE-------RYEP-------LEARDLLSFIVYY
INSR_Hsap NGDQASCENELLKFSYIRTSFDKILLRWE-------PYWP-------PDFRDLLGFMLFY
IGF1R_Hsap NGERASCESDVLHFTSTTTSKNRIIITWH-------RYRP-------PDYRDLISFTVYY
InR_Dmel NGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYH
IRR_Mmus NGDRAACQTRTLRFVFNLTEEDRILLRWE-------RYEP-------LEARDLLSFIVYY
INSR_Mmus NGDQASCENELLKFSFIRTSFDKILLRWE-------PYWP-------PDFRDLLGFMLFY
IGF1R_Mmus NGERASCESDVLRFTSTTTWKNRIIITWH-------RYRP-------PDYRDLISFTVYY
daf-2_Cele NGEKAICEDMAINVSITAVNADSVFFSWP-------SFNI-----TDIDQRKFLGYELFF
ILGFR_Spur ----------AEVVGSVSRFLNTVVVSY----QSDS-----------PSLSNKDQYPYYF
InsRL_Spur ------------------------------------------------------------
IRR_Hsap KESPF--QNATEHVGPDACGTQSWNLLDVELPLSR-------TQEPG--VT-----LASL
INSR_Hsap KEAPY--QNVTEFDGQDACGSNSWTVVDIDPPLRSNDPK--SQNHPG--WL-----MRGL
IGF1R_Hsap KEAPF--KNVTEYDGQDACGSNSWNMVDVDLPPNK-------DVEPG--IL-----LHGL
InR_Dmel MIDPY--GNSTKS-SDDPCD-DRWKVS-------S-------PEKSG-VMV-----LSNL
IRR_Mmus KESPF--QNATEHVGPDACGTQSWNLLDVELPLSR-------TQEPG--VT-----LAPL
INSR_Mmus KEAPY--QNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPG--WL-----MRGL
IGF1R_Mmus KEAPF--KNVTEYDGQDACGSNSWNMVDVDLPPNK-------EGEPG--IL-----LHGL
daf-2_Cele KEVPRIDENMTIEEDRSAC-VDSWQSVFKQYYETS-------NGEPTPDIFMDIGPRERI
ILGFR_Spur RTFP--DTTEQCYAL---------------------------------------IELFQN
InsRL_Spur -------------------------------------------QDAG--TT---------
IRR_Hsap KPWTQYAVFVRAITLTT-----EEDSPHQGAQSPI--VYLRTLPAAPT-VPQDVISTSNS
INSR_Hsap KPWTQYAIFVKTLV-TF-----SDERRTYGAKSDI--IYVQTDATNPS-VPLDPISVSNS
IGF1R_Hsap KPWTQYAVYVKAVTLTM-----VENDHIRGAKSEI--LYIRTNASVPS-IPLDVLSASNS
InR_Dmel IPYTNYSYYVRTMAI---------SSELTNAESDV--KNFRTN---PG-RPSKVVATAIS
IRR_Mmus KPWTQYAVFVRAITLTT-----AEDSPHQGAQSPI--VYLRTLPAAPT-VPQDVISTSNS
INSR_Mmus KPWTQYAIFVKTLV-TF-----SDERRTYGAKSDI--IYVQTDATNPS-VPLDPISVSNS
IGF1R_Mmus KPWTQYAVYVKAVTLTM-----VENDHIRGAKSEI--LYIRTNASVPS-IPLDVLSASNS
daf-2_Cele RPNTLYAYYVATQM-VL-------HAGAKNGVSKI--GFVRTSYYTPD-PPTLALAQVDS
ILGFR_Spur FGWGRYALLSDSEDITYKVMKNMEEVMIEGGIEMVVDIYMATNEVNQAAVTSYLEEIVSK
InsRL_Spur -PTTT--------------------------------SFITPIPTTPT-------SG---
. .
IRR_Hsap SSHLLVRWKPPTQRNGNL--------------TYYLVLWQRLAE-DGDLYLNDY------
INSR_Hsap SSQIILKWKPPSDPNGNI--------------THYLVFWERQAE-DSELFELDY------
IGF1R_Hsap SSQLIVKWNPPSLPNGNL--------------SYYIVRWQRQPQ-DGYLYRHNY------
InR_Dmel DSKINVTWSYLDKPYGVL--------------TRYFIKAKLINR-PTRNNNRDY------
IRR_Mmus SSHLLVRWKPPVQRNGNI--------------TYYLVLWQRLAE-DGDLYINDY------
INSR_Mmus SSQIILKWKPPSDPNGNI--------------THYLVYWERQAE-DSELFELDY------
IGF1R_Mmus SSQLIVKWNPPTLPNGNL--------------SYYIVRWQRQPQ-DGYLYRHNY------
daf-2_Cele -DAIHITWEAPLQPNGDL--------------THYTIMWRENEV-SPYEEAEKF------
ILGFR_Spur KAHIIVGYFPENVARLVLCEAHKQGLTGEKGYQWFLPEWYQDAWWDT-----DYHNKNSP
InsRL_Spur ------------------------------------------------------------
IRR_Hsap -----CHRGLRLPTSN-N----------------------------DPRFDGEDGDPEA-
INSR_Hsap -----CLKGLKLPSRT-W----------------------------SPPFESEDSQKHNQ
IGF1R_Hsap -----CSKD-KIPIRK-Y---------------------------ADGTIDIEEVTENPK
InR_Dmel -----CTEPLVKAME--ND-----------LPATTPT-----------------------
IRR_Mmus -----CHRGLRLPTSS-H----------------------------DTRFDREDPALEA-
INSR_Mmus -----CLKGLKLPSRT-W----------------------------SPPFESDDSQKHNQ
IGF1R_Mmus -----CSKD-KIPIRK-Y---------------------------ADGTIDVEEVTENPK
daf-2_Cele -----CTDA-STPANR-QHTKDPKETIVADKPVDIPSSR-----TVAPTLLTMMGHED-Q
ILGFR_Spur SYSIFSTSPSSFNISCTTT-----EMMQAIKGYISL-SRAYIANWD-KPVPGHETVEGWI
InsRL_Spur ------------------------------------------------------------
IRR_Hsap ----E-MESDCCPCQHPPPGQV---LPPLEAQEASFQKKFENFLHNAITIPISPWKVTSI
INSR_Hsap SEY-EDSAGECCSCP---KTDS---QILKELEESSFRKTFEDYLHNVVFVPRKTS---SG
IGF1R_Hsap TEVCGGEKGPCCACP---KTEA---EKQAEKEEAEYRKVFENFLHNSIFVPRP-------
InR_Dmel KKISDP-LAGDCKCVEGSKKT--S-SQEYDDRKVQAGMEFENALQNFIFVPNIRK---SK
IRR_Mmus ----E-PEQGCCPCQHSPPGQA---LPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSI
INSR_Mmus SEY-DDSASECCSCP---KTDS---QILKELEESSFRKTFEDYLHNVVFVPRKTS---SG
IGF1R_Mmus TEVCGGDKGPCCACP---KTEA---EKQAEKEEAEYRKVFENFLHNSIFVPRP-------
daf-2_Cele QKTCAA-TPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRS
ILGFR_Spur NE----------------------------------------------------------
InsRL_Spur ------------------------------------------FNLNGSLYPSSPA--TGV
IRR_Hsap NKSPQ--------------------RDSGRHRRAA----GPL------------------
INSR_Hsap TGAED--------------------PRPSRKRRSL----GDV---GN---------VT--
IGF1R_Hsap ----------------------------ERKRRDV----MQV---AN---------TT--
InR_Dmel NGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDV----ALEPELDD---------VEGS
IRR_Mmus NKNPQ--------------------RDSERHRREA----GLL------------------
INSR_Mmus NGAED--------------------SRPSRKRRSL----EEV---GN---------VT--
IGF1R_Mmus ----------------------------ERRRRDV----MQV---AN---------TT--
daf-2_Cele IEDAN--------------------RVSEELEKAENLGKAPK-TLGGKKPLIHISKKKPS
ILGFR_Spur -----------------------------------------------YNSLIE-------
InsRL_Spur N-AST--------------------TSPSRV-----------------------------
IRR_Hsap ------------------------------RLG-GNSSD----FEIQE----------D-
INSR_Hsap --------VAVPTVAA--FPNTSST-----SVP-TSPEE----HRPFE----------K-
IGF1R_Hsap --------MSSRSRNT-TAADTYNI-----TDP-EELET---EYPFFE----------SR
InR_Dmel VLLRHVRSITDDTDAFFEKDDENTY-----KDE-EDLSSNKQFYEVFA----------KE
IRR_Mmus ------------------------------RLG-KNNSD----FEIQE----------D-
INSR_Mmus --------ATTLTLPD--FPNVSST-----IVP-TSQEE----HRPFE----------K-
IGF1R_Mmus --------MSSRSRNT-TVADTYNI-----TDP-EEFET---EYPFFE----------SR
daf-2_Cele S--S----STTSTPAP-TIASMYALTRKPTTVPGTRIR----LYEIYEPLPGSWAINVSA
ILGFR_Spur ----------------------------------------------KE----------GK
InsRL_Spur ----------------------------------------------EE----------RV
IRR_Hsap K-VPRERAVLSGLRHFT-EYRIDIHACNH-AAHTV----------GCSAATFV--FARTM
INSR_Hsap V-VNKESLVISGLRHFT-GYRIELQACNQ-DTPEE----------RCSVAAYV--SARTM
IGF1R_Hsap V-DNKERTVISNLRPFT-LYRIDIHSCNH-EAEKL----------GCSASNFV--FARTM
InR_Dmel LPPNQTHFVFEKLRHFT-RYAIFVVACRE-EIPSEKLRDTSFKKSLCSDYDTV--FQTTK
IRR_Mmus K-VPRERAILSGLRHFT-EYRIDIHACNH-AAHTV----------GCSAATFV--FARTM
INSR_Mmus V-VNKESLVISGLRHFT-GYRIELQACNQ-DSPDE----------RCSVAAYV--SARTM
IGF1R_Mmus V-DNKERTVISNLRPFT-LYRIDIHSCNH-EAEKL----------GCSASNFV--FARTM
daf-2_Cele L-ALDNSYVIRNLKHYT-LYAISLSACQNMTVPGA----------SCSISHRAGALKRTK
ILGFR_Spur MP--STYAAYAYDTVWTYAYALDKLLFNDV-AA--------LDTLSSQQTI--RTYLRHL
InsRL_Spur I-GLVESFHVTGLEHFT-EYFITLQACNS-K--------------DCSRAAAM--YGRSL
:* * : . ..
IRR_Hsap PH----------READGIPGK-VAW--EASS-KNSVLLRWLEPPDPNGLILKYEIKYRRL
INSR_Hsap PE----------AKADDIVGP-VTH--EIFE-NNVVHLMWQEPKEPNGLIVLYEVSYRRY
IGF1R_Hsap PA----------EGADDIPGP-VTW--EPRP-ENSIFLKWPEPENPNGLILMYEIKYGSQ
InR_Dmel RK----------KFADIVMDLKVDLEHANNT-ESPVRVRWTPPVDPNGEIVTYEVAYKLQ
IRR_Mmus PH----------READGIPGK-VAW--KAAG-KSSVTLHWLEPPDPNGLILKYEIKYRRL
INSR_Mmus PE----------AKADDIVGP-VTH--EIFE-NNVVHLMWQEPKEPNGLIVLYEVSYRRY
IGF1R_Mmus PA----------EGADDIPGP-VTW--EPRP-ENSIFLKWPEPENPNGLILMYEIKYGSQ
daf-2_Cele HI----------TDIDKVLNETIEW--RFMNNSQQVNVTWDPPTEVNGGIFGYVVKLKSK
ILGFR_Spur SN----------TSFSGVTGE-V--KFMDQDRRGPISIHQHHPPTT-TIIGSYIPDMDTK
InsRL_Spur PKGWSHLRYDGRESADQIESA-VMI--NHTS-TDRVHLTWAEPSNPNGIIVIHEIRFEMM
. : . : : : * * :
IRR_Hsap GE---------------------------EATVLCVSRLR-Y-AKFGGVHLALLPPGNYS
INSR_Hsap GD---------------------------EELHLCVSRKH-F-ALERGCRLRGLSPGNYS
IGF1R_Hsap VE---------------------------D-QRECVSRQE-Y-RKYGGAKLNRLNPGNYT
InR_Dmel KPD-------------------------QVEEKKCIPAAD-F-NQTAGY-LIKLNEGLYS
IRR_Mmus GE---------------------------EATVLCVSRLR-Y-AKVGGVHLALLPPGNYS
INSR_Mmus GD---------------------------EELHLCVSRKH-F-ALERGCRLRGLSPGNYS
IGF1R_Mmus VE---------------------------D-QRECVSRQE-Y-RKYGGAKLNRLNPGNYT
daf-2_Cele VDG-------------------------SIVMTRCVGAKRGYSTRNQGVLFQNLADGRYF
ILGFR_Spur DQG-------------------------S--LS------------------LN-TSGIMW
InsRL_Spur DVEVDDVGDERDAYTVVESHSTPKPVTQSTENTECVSAEG-Y-KRVLGAELLGLKVGNYT
*
IRR_Hsap ARVRATSLAGNGSWTDSVAFYILGPEEEDAGG--------LHVLLTATPVGLTLLIV-LA
INSR_Hsap VRIRATSLAGNGSWTEPTYFYVTDYLDVPSNI--------AKIIIG--PLIFVFLFSVVI
IGF1R_Hsap ARIQATSLSGNGSWTDPVFFYVQAKTGYENFI---------HLII-ALPVAVLLIVGGLV
InR_Dmel FRVRANSIAGYGDFTEVEHIKVEPPPSYAK---------VFFWLL-GIGLAF-LIVSLFG
IRR_Mmus AKVRATSLAGNGSWTDGVTFYITDLEEEDTGG--------MRIFLTVTPVGFMLLVT-LA
INSR_Mmus VRVRATSLAGNGSWTEPTYFYVTDYLDVPSNI--------AKIIIG--PLIFVFLFSVVI
IGF1R_Mmus ARIQATSLSGNGSWTDPVFFYVPAKTTYENFM---------HLII-ALPVAILLIVGGLV
daf-2_Cele VSVTATSVHGAGPEAESSDPIVVMTPGF--FT--------VEIILG-MLLVFLILMSIAG
ILGFR_Spur ASGSQPTDGANGPTCMVEGLR----QALGSDC-RTAI------ALMNTILLLVILVSTII
InsRL_Spur AMVRAVSLAGEGPWTKPVMFSVPDITNNPTYEPDKALPPMMGVTI-AVSIAAVIIIIVFI
: . * : : ::.
IRR_Hsap ALGFFYGKKRN-R-----T-LYASVNPEYFSASD------MYVPDEWEVPREQISIIREL
INSR_Hsap GSIYLFLRKRQPDG-PLGP-LYASSNPEYLSASDV-FPCSVYVPDEWEVSREKITLLREL
IGF1R_Hsap IMLYVFHRKRNNSRLGNGV-LYASVNPEYFSAAD------VYVPDEWEVAREKITMSREL
InR_Dmel YVCYLH--KRKVPS-NDLH-MNTEVNPFY--ASM------QYIPDDWEVLRENIIQLAPL
IRR_Mmus ALGFFYSRKRN-S-----T-LYTSVNPEYFSASH------MYVPDEWEVPREQIAIIREL
INSR_Mmus GSIYLFLRKRQPDG-PMGP-LYASSNPEYLSASDVVFPSSVYVPDEWEVPREKITLLREL
IGF1R_Mmus IMLYVFHRKRNNSRLGNGV-LYASVNPEYFSAAD------VYVPDEWEVAREKITMNREL
daf-2_Cele CIIYYYIQVRYGKKVKALS-DFMQLNPEYC-VDN------KYNADDWELRQDDVVLGQQC
ILGFR_Spur --LAVFIKRRYDRKVKRTEQHIKQLTLMGLGEGA------LITLDEWEMPRENVVLNRKL
InsRL_Spur I-IFLRWHYRKDQM-PDGV-LYASVNPEYMSTSD------MYVADEWEFPRDKLEIIREL
* . . *:**. ::.:
IRR_Hsap GQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASPRECIEFLKEASVMKAFKCHHV
INSR_Hsap GQGSFGMVYEGNARDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHV
IGF1R_Hsap GQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHV
InR_Dmel GQGSFGMVYEGILKSFPP--NGV-DRECAIKTVNENATDRERTNFLSEASVMKEFDTYHV
IRR_Mmus GQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASARERVEFLKEASVMKAFKCHHV
INSR_Mmus GQGSFGMVYEGNAKDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHV
IGF1R_Mmus GQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHV
daf-2_Cele GEGSFGKVYLGTGNNVVSLMGDR-FGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFI
ILGFR_Spur GEGAFGTVYGGEA--LLD--DNK-WAAVAVKTLKLGASVEEKLDFLSEAEVMKRFNHKNI
InsRL_Spur GKGSFGMVYEGLAKGILP--EEEEISRVAIKSVQANASMRDRIEFLNEASVMKLIDAHNV
*:*:** ** * . *:* .: : ::* **.:** : :
IRR_Hsap VRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPGL------------PQPAL
INSR_Hsap VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE-NNPGR------------PPPTL
IGF1R_Hsap VRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME-NNPVL------------APPSL
InR_Dmel VRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEER-DEAMMTYLNRIGVTGNVQPPTY
IRR_Mmus VRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPGL------------PQPAL
INSR_Mmus VRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAE-NNPGR------------PPPTL
IGF1R_Mmus VRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLVL------------IPPSL
daf-2_Cele VKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVF-NETDC--------NFFDIIPR
ILGFR_Spur VNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGE-GVYER--------N-QHVMCP
InsRL_Spur VRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQ-QDLPLI--------DRKSVPTL
*.* ** : :* .:**:* *:*: * . *
IRR_Hsap GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKG
INSR_Hsap QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG
IGF1R_Hsap SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG
InR_Dmel GRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKG
IRR_Mmus SDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKG
INSR_Mmus QEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG
IGF1R_Mmus SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG
daf-2_Cele DKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPS
ILGFR_Spur DQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRALYDSDYYRLG
InsRL_Spur EQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQSDYYRKE
: . . :*..*:::* : :: ****:.***:: . * *:.***::* :: ***:
IRR_Hsap GKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV-MDG
INSR_Hsap GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG
IGF1R_Hsap GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG
InR_Dmel TKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV-IDG
IRR_Mmus GKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV-MDG
INSR_Mmus GKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG
IGF1R_Mmus GKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG
daf-2_Cele GKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMAR
ILGFR_Spur KRSKLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNAEVLDYI-RNR
InsRL_Spur RGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAGEYI-KGG
:*:***.***: :* : : **::*:*::::*:.::. ** *** :. ::
IRR_Hsap GVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEE-------------------
INSR_Hsap GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDD-------------------
IGF1R_Hsap GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEE-------------------
InR_Dmel GVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQ-------------------
IRR_Mmus GVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDE-------------------
INSR_Mmus GYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDD-------------------
IGF1R_Mmus GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDE-------------------
daf-2_Cele KVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAE-------------------
ILGFR_Spur NSLRPPEGCSPALGALMMQCWAIQPQHRPTAKDVNDILCQRPHLITPCLGVPLGSIPPEE
InsRL_Spur NVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDYG------------------
: : * :* ** ** .: :
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------------------------------
InR_Dmel ------------------------------------------------------------
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------------------------------
daf-2_Cele ------------------------------------------------------------
ILGFR_Spur IHSTGLPLSPVRPKHPAPKHSTRSNSSTEMHMGREFNRIHDDEFLTGHLASVGHIFRASK
InsRL_Spur ------------------------------------------------------------
IRR_Hsap ----LRPSFRLLSFYYSPECRG--------------------------------------
INSR_Hsap ----LHPSFPEVSFFHSEENKA--------------------------------------
IGF1R_Hsap ----MEPGFREVSFYYSEENKL--------------------------------------
InR_Dmel ---CPNSQFKEVSFYHSEAGLQ--------------------------------------
IRR_Mmus ----LRPSFRLCSFYYSPECQR--------------------------------------
INSR_Mmus ----LHPSFPEVSFFYSEENKA--------------------------------------
IGF1R_Mmus ----MEPSFQEVSFYYSEENKP--------------------------------------
daf-2_Cele ----ASPEFRDLSFVLTDNQMI--------------------------------------
ILGFR_Spur RRSKNKKSFSRCSFELAPSGSRRLRRDSETERNCISIISSTASAPSTSMSNTSTPSTSQD
InsRL_Spur ---LLRDSFAQNCFFLNEQLNA--------------------------------------
* .*
IRR_Hsap ----------------------------------------------------ARGSLPTT
INSR_Hsap ----------------------------------------------------PESEELEM
IGF1R_Hsap ----------------------------------------------------PEPEELDL
InR_Dmel ---------------------------------------------------HREKERKER
IRR_Mmus ----------------------------------------------------GQASLLPT
INSR_Mmus ----------------------------------------------------PESEELEM
IGF1R_Mmus ----------------------------------------------------PEPEELEM
daf-2_Cele ---------------------------------------------------LDDSEALDL
ILGFR_Spur SCVVAVEDLPPVIHRGRSRTSATLEHNFLHRLPSGGTFTKLLKKAATEDNIYSESESRQH
InsRL_Spur ----------------------------------------------------SAA-PADM
IRR_Hsap D-----------------------------AEP-DSSPT---------PRD---C-----
INSR_Hsap E-----------------------------FEDMENVPL---------DRSSHCQ-----
IGF1R_Hsap E-----------------------------PENMESVPL---------DPSASSS-----
InR_Dmel NQ----------------------------LDAFAAVPL---------DQDLQDREQQED
IRR_Mmus E-----------------------------AEP-DSPPT---------LNGASDY-----
INSR_Mmus E-----------------------------FEDMENVPL---------DRSSHCQ-----
IGF1R_Mmus E-----------------------------PENMESVPL---------DPSASSA-----
daf-2_Cele DD-IDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATTSHS-----
ILGFR_Spur SWSL-----------------FSCI----DSERFEGLPL---------LQHQSSR-----
InsRL_Spur S-----------------------------SKELETVSIL--------DQNAKN------
. .
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------------------------------
InR_Dmel ATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQN
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------------------------------
daf-2_Cele ----------------------------------TISIDETPMKAKQREGSLDEEYALMN
ILGFR_Spur ------------------------------------------------------------
InsRL_Spur ------------------------------------------------------------
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ------------------------------------SLPLP-------------------
InR_Dmel IPAAQGDISATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPR
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ------------------------------------SLPLP-------------------
daf-2_Cele HSGGPSDAEVRTYAGDGDYVERDV---------RENDVPTR-------------------
ILGFR_Spur ------------------------------------RG----------------------
InsRL_Spur ------------------------------------NENLY-------------------
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ------------------------------------------------------------
IGF1R_Hsap ----------------------------------DRHSGH--------------------
InR_Dmel KGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTGRPSLKKTVADSVRNKANFINR
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ------------------------------------------------------------
IGF1R_Mmus ----------------------------------ERHSGH--------------------
daf-2_Cele -----------------------------------RNTGAS-------------------
ILGFR_Spur --------------------------------------SK--------------------
InsRL_Spur ----------------------------------TSMSNN--------------------
IRR_Hsap --------------S---------P-----------------------------------
INSR_Hsap --------------R---------E------------------E--AGGRDGGSSLGFK-
IGF1R_Hsap --------------K---------A------------------E--NGP--GPGVLVLR-
InR_Dmel HLFNHKRTGSNASHKSNASNAPSTSSNTNLTSHPVAMGNLGTIES-GGSGSAGSYTGTPR
IRR_Mmus --------------S---------A-----------------------------------
INSR_Mmus --------------R---------E------------------E--AGGREGGSSLSIK-
IGF1R_Mmus --------------K---------A------------------E--NGP--GPGVLVLR-
daf-2_Cele -------------TSSYTGGGPYCL------------------TNRGGSNERGAGFGEAV
ILGFR_Spur --------------R------PRSK------------------S--LGSKSSGSK-----
InsRL_Spur --------------K------PEGA------------------SN-GGNRAGGSVEVPI-
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ---------------------------------------------RSYEEH---------
IGF1R_Hsap ---------------------------------------------ASFDER---------
InR_Dmel FYTPSATPGGGSGMAISD------------NPNYRLLDESIASEQATILTTSSPNPNYEM
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ---------------------------------------------RTYDEH---------
IGF1R_Mmus ---------------------------------------------ASFDER---------
daf-2_Cele R----------------LTDGVGSGHLNDDD--------YVEKEISSMDTRRSTGASSS-
ILGFR_Spur ---------------------------------------------SPSSKH---------
InsRL_Spur ---------------------------------------------VTGPSS---------
IRR_Hsap ------------------------------------------------------------
INSR_Hsap ----IPY-----------------------------------------------------
IGF1R_Hsap ----QPY-----------------------------------------------------
InR_Dmel MHPP--TSLVSTNPNYMPMNETPVQMAGVTISHNPNYQPMQAPLNARQSQSSSDEDNEQE
IRR_Mmus ------------------------------------------------------------
INSR_Mmus ----IPY-----------------------------------------------------
IGF1R_Mmus ----QPY-----------------------------------------------------
daf-2_Cele -SYGVPQ--TNWSGN-----------RGA-------------TYYTSKAQQAATAAAAAA
ILGFR_Spur ----SLY-----------------------------------------------------
InsRL_Spur ----SPK--DR-------------------------------------------------
IRR_Hsap ----------------------QNGG----------------------------------
INSR_Hsap --------------------THMNGGKKNGRILTLP------------------------
IGF1R_Hsap --------------------AHMNGGRKNERALPLP------------------------
InR_Dmel EDDEDEDDDVDDEHVEHIKMERMPLSRPRQRALPSKTQ-----------------PPRS-
IRR_Mmus ----------------------PNGG----------------------------------
INSR_Mmus --------------------THMNGGKKNGRVLTLP------------------------
IGF1R_Mmus --------------------AHMNGGRANERALPLP------------------------
daf-2_Cele A----------------ALQQQQNGGRG-DRLTQLPGTGHLQSTRGGQDGDYIETEPKNY
ILGFR_Spur -----------------VT-LSRNGFDDSKEEETMI------------------------
InsRL_Spur -------------------NGSLTGNGSIPHGVGVG------------------------
IRR_Hsap --------------------------------------------------PGH
INSR_Hsap ------------------------------------------------RSNPS
IGF1R_Hsap ------------------------------------------------QSSTC
InR_Dmel RSVSQTRKSPTNPNSGIGATGAGNRSNLLKENWLRPASTPRPPPPNGFIGREA
IRR_Mmus --------------------------------------------------PGH
INSR_Mmus ------------------------------------------------RSNPS
IGF1R_Mmus ------------------------------------------------QSSTC
daf-2_Cele RNNGSPSRNGNSRDIFNGRSAFGENEHLIED-------NE--------HHPLV
ILGFR_Spur ------------------------------------------------SFVSN
InsRL_Spur ------------------------------------------------KCTEC