RAF1_Hsap_RAF MEHI-QGAWKTI--SNG-FGFK----------------D-AVFD--------------GS
KSR2_Hsap_KSR MDEE-NMTKSEEQQ-----------------------------------------P----
KSR1_Hsap_KSR MDRA-ALRAAAMGEKKEGGGGG----------------DAAAA------EGGA--G----
phl_Dmel_RAF MSSE-SSTEGDS--D---------------------------------------------
ksr_Dmel_KSR MSSN-NNAPASAPD--T--GST------------------NA---------ND--P----
KSR2_Mmus_KSR MDEE-NMTKSEEQQ-----------------------------------------P----
KSR1_Mmus_KSR MDRA-ALRAAAMGEKKEGGGGG------------------AAA------DGGA--G----
BRAF_Mmus_RAF MAAL-SGGGGSS--SGG-GGGGGGGGGGGDGGGGAEQGQ-ALFNGDMEPEAGA--GAAAS
ARAF_Mmus_RAF MEPP-RGPPVSG--A---------------------------------------------
lin-45_Cele_RAF MSRI-NFKKSSA--STT-PT--------------------------------------SP
ksr-2_Cele_RAF MSDE-KKKKRGFFR-----------------------------------------Y----
ksr-1_Cele_KSR MMQT-QVASRAGY-SNL-PQF------------------------------GA--G----
BRAF_Hsap_RAF MAAL-SGGGGGG--AE--------------------PGQ-ALFNGDMEPEAGAGAGAAAS
ARAF_Hsap_RAF MEPP-RGPPANG--A---------------------------------------------
RAF1_Mmus_RAF MEHI-QGAWKTI--SNG-FGLK----------------D-AVFD--------------GS
KSR1_Spur_KSR LLME-KVQ----------------------------------------------------
Raf_Spur_RAF MGDR-TKT----------------------------------------------------
KSR2_Spur_KSR MQPK-EHIALIM------------------------------------------------
AqueK675_Aque_KSR MSTR-RDILSL-L-----------------------------------------------
AqueK676_Aque_KSR MSAT-TATAVYS--SSI--GQ------------------------------TQ--D-DKK
AqueK677_Aque_RAF MESA-QFLE---------------------------------------------------
AqueK678_Aque_RAF DYFIPSAST---------------------------------------------------
AqueK679_Aque_RAF MATD-SATEDGE------------------------------------------------
RAF1_Hsap_RAF SCISPTI---------------------VQQF----------------------------
KSR2_Hsap_KSR LSLQKAL-QQCELVQNMIDLSISNLEGLRTKCA-----TSNDLT---QKEIRTLESKLVK
KSR1_Hsap_KSR AAASRAL-QQCGQLQKLIDISIGSLRGLRTKCA-----VSNDLT---QQEIRTLEAKLVR
phl_Dmel_RAF -LYDP-LAEELHNVQLVKHVTRENIDALNAKF----------------------------
ksr_Dmel_KSR ISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCA-----ISSTLT---QQEIRCLESKLVR
KSR2_Mmus_KSR LSLQKAL-QQCELVQNMIDLSISNLEGLRTKCA-----ASNDLT---QKEIRTLESKLVK
KSR1_Mmus_KSR AAVSRAL-QQCGQLQKLIDISIGSLRGLRTKCS-----VSNDLT---QQEIRTLEAKLVK
BRAF_Mmus_RAF SAADPAIPEEVWNIKQMIKLTQEHIEALLDKF----------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF HCPSPRL-----------------------------------------------------
ksr-2_Cele_RAF SVL---------------------------------------------------------
ksr-1_Cele_KSR ------------IAQDIKTQAINNLKECLKLTT-----INRFLTSSYEEDAKSVERKIFS
BRAF_Hsap_RAF SAADPAIPEEVWNIKQMIKLTQEHIEALLDKF----------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF SCISPTI---------------------VQQF----------------------------
KSR1_Spur_KSR ------------NLSHLI------------------------------------------
Raf_Spur_RAF --------EQLNVIHMHMELKKKNIEELMERF----------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR DLFSVT-KGKMKVQQRMIDLTARELESTRVSSQSIPSDGSSDAL---KENIVLVENKLMK
AqueK677_Aque_RAF ----------VQAIRQVIRSTRTTLDEFQRSF----------------------------
AqueK678_Aque_RAF ----------LHATEIANHITEINLEKSETKY----------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR YFSRQLSCKKKVALQE--------------RNAEL-----DGFPQLRHWFRIVDVRKEVL
KSR1_Hsap_KSR YICKQRQCKLSVAPGE--------------RTPEL-----NSYPRFSDWLYTFNVRPEVV
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR YFSELLLAKMR--LNE--------------RIPANGLVPHTTGNELRQWLRVVGLSQGTL
KSR2_Mmus_KSR YFSRQLSCKKKVALQE--------------RNAEL-----DGFPQLRHWFRIVDVRKEVL
KSR1_Mmus_KSR YICKQQQSKLSVTPSD--------------RTAEL-----NSYPRFSDWLYIFNVRPEVV
BRAF_Mmus_RAF ------------------------------------------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR AVY---QMT-KIGLID-------------REKREI-----NA-----IWFTFVGLSAQNI
BRAF_Hsap_RAF ------------------------------------------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF ------------------------------------------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ---------------H-------------HQQ----------------------------
AqueK676_Aque_KSR LFSRQLMHK-HICLKELINAGGVSHFDFEQTNDEL-----DSLISFKMFLTVTGLEELSV
AqueK677_Aque_RAF ------------------------------------------------------------
AqueK678_Aque_RAF ------------------------------------------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ---------------------------------------------------------G--
KSR2_Hsap_KSR EEIS--PGQLSLEDLLEMTDEQVCETVEKYGAN--REECARLNASLSCLRNVH-------
KSR1_Hsap_KSR QEI---PRDLTLDALLEMNEAKVKETLRRCGAS--GDECGRLQYALTCLRKVT-------
phl_Dmel_RAF ---------------------------------------------------------ANL
ksr_Dmel_KSR TACL--ARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCM-------
KSR2_Mmus_KSR EEIS--PDQLSLEDLLEMTDEQVCETVEKYGAN--QEECARLNASLSCLRNVH-------
KSR1_Mmus_KSR QEI---PQELTLDALLEMDEAKAKEMLRRWGAS--TEECSRLQQALTCLRKVT-------
BRAF_Mmus_RAF ---------------------------------------------------------GGE
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ------------------------------------------------TTS---------
ksr-1_Cele_KSR RHLEI-CSITDFNALFSITNQELRSLADRGRLD--VETKRKLLQSTVILQNHW-------
BRAF_Hsap_RAF ---------------------------------------------------------GGE
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ---------------------------------------------------------G--
KSR1_Spur_KSR ----------------KHGESEIRTIMKICGC--EEKEITRLLDAVKNLKKTF-------
Raf_Spur_RAF ---------------------------------------------------------GTE
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR KSLSSEKEKLSVDRLFQMTPQELQYLFSRLEIT--ARDCHKLVSLLDLMSLYYEKWEKGE
AqueK677_Aque_RAF ---------------------------------------------------------PYG
AqueK678_Aque_RAF ---------------------------------------------------------INI
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR ------------------MS--------------GGN---LSKQDWTIQWPTTET----G
KSR1_Hsap_KSR ------------------GL--------------GGE---H-KED--SSWSSLDARRESG
phl_Dmel_RAF QEPPAMYLIEYQELTSKLHELEAKEQELMERLNSQDQQED-------S-----S------
ksr_Dmel_KSR ------------------E-----------SLESGTAASNNDPEQ--WHWDSWDRPTHIH
KSR2_Mmus_KSR ------------------KS--------------GGN---LSKQDWIIQWPTTEP----G
KSR1_Mmus_KSR ------------------GL--------------GGE---H-KMD--SGWSSTDARDSS-
BRAF_Mmus_RAF HNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGADFSV-------S-----S------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF --------ISLP------------------------RCAS-------S-----S------
ksr-2_Cele_RAF --------------------SFSSWRR---SSTSG-------------------------
ksr-1_Cele_KSR ------------------------NAYHSR-TSSGST----------------D------
BRAF_Hsap_RAF HNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSV-------S-----S------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ------------------NANYPSKDR---SLEDGAKS--------------PDAVS---
Raf_Spur_RAF QPPPPIFLEEYQDLTDQLSELQVEEQRINNEMSNGHT-----------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR -------------------------------KTRGTD-----------------------
AqueK676_Aque_KSR NPPPGLYDVRRNSSSGRLNSLTSLESRKDS-TSSHTI----------------S------
AqueK677_Aque_RAF QR-TSLVVEEESELKKRLEDLMRREKELSG---QGWDSS--------------D------
AqueK678_Aque_RAF RESPSMAAGAVEVVTNQVEEREAA-KECVESLVSQHRKE--------------D------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR -----------K---ENNPVCPPEPTPWIRT-HLSQSPRVPSK------------CVQHY
KSR1_Hsap_KSR SGPSTD---TLS---AASLPWPPGSSQLGRAGNSAQGPRS--------------------
phl_Dmel_RAF -LVERF---KEQ--PHYQNQT-------------QILQ----------------------
ksr_Dmel_KSR RGSVG-----N--------------IGLG--NNSTASPRTHHRQHGVKGKNSALANSTNF
KSR2_Mmus_KSR -----------Q---ESNPVCPPEPSPWIRT-HLSQSPRVQTK------------CPQHF
KSR1_Mmus_KSR LGPPMD---ML--------------SSLGRAGASTQGPRS--------------------
BRAF_Mmus_RAF -SASMD---TVT--SSSSSSL-------------SVLP----------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF -IDRKD---QAS--PMASPST-------------PLYP----------------------
ksr-2_Cele_RAF --S------------------------------ISQSSRTTSK------------TT---
ksr-1_Cele_KSR -EP--------S--GQSTPAI-------------V-TP-----------------SPKF-
BRAF_Hsap_RAF -SASMD---TVT--SSSSSSL-------------SVLP----------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR MGNSIE---TV--------------IDLS--RSRSNSPSV--------------------
Raf_Spur_RAF -SPNLQ---TTP--PPEPADL-------------H-VP----------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ---------------QSSPVN-------------V-------------------------
AqueK676_Aque_KSR -PPAGN---HGS--RSSTPLT-------------PLTP-----------------SSTQS
AqueK677_Aque_RAF -SAEQE---LVS--SSSPDGS-------------DQSP----------------------
AqueK678_Aque_RAF -CQQKECLKIDEYGISSIS-----------------------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR CHTSPTPG--APVYTHVDRLT--VDAYPGLC-----------------------------
KSR1_Hsap_KSR -------------------IS--VSALPASD-----------------------------
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR KSGRQSPSA-------TEELNSTQGSQLTLT-----------------------------
KSR2_Mmus_KSR CPTSPTPG--TPVYTQVDRLT--VDAYPNLC-----------------------------
KSR1_Mmus_KSR -------------------IS--VSALPASD-----------------------------
BRAF_Mmus_RAF ------------------------------------------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ---TSS--------------S--VTSSNPIN-----------------------------
ksr-1_Cele_KSR ---------N----------------VPSLSV----------------------------
BRAF_Hsap_RAF ------------------------------------------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ---SSSPEQKRP---SIDSLSSDLSEVPSVP-----------------------------
Raf_Spur_RAF -------------------------------YHNK-------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ---------A----------------VPSITV----------------------------
AqueK676_Aque_KSR PFQGLVHQNS----------------TPSIPTHSVPYDNIRSTSSCGCGGHALSESSGQH
AqueK677_Aque_RAF ------------------------------------------------------------
AqueK678_Aque_RAF ------------------------------------------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ----------------------------------------------Y-QRRA--SD----
KSR2_Hsap_KSR ---------------------------------------------P--P-PP--LESGHR
KSR1_Hsap_KSR ---------------------------------------------SP-T-PS--FSEGLS
phl_Dmel_RAF --------------------------Q----QR----------QLARVHHGNDLTD----
ksr_Dmel_KSR ---------------------------------------------LT-P-SP--------
KSR2_Mmus_KSR ---------------------------------------------PP-P-PP--LESGHR
KSR1_Mmus_KSR ---------------------------------------------SP-V-PG--LSEGLS
BRAF_Mmus_RAF --------------------------S----------------SLSV-FQTP--TD----
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF --------------------------KHSDSLH----------SLSG-HHSA--GG----
ksr-2_Cele_RAF ---------------------------------------------AP-P-PT--ATS---
ksr-1_Cele_KSR ---------------------------------------T---SAKM-IQSS--SM----
BRAF_Hsap_RAF --------------------------S----------------SLSV-FQNP--TD----
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ----------------------------------------------Y-QRRA--SD----
KSR1_Spur_KSR ---------------------------------------------IT-P-PP--FNNKIF
Raf_Spur_RAF --------------------------Q----------------SLAP-PHKR--EF----
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ---------------------------------------SSPRSRSN-SRNA--VI----
AqueK676_Aque_KSR LSSSMSSLGSDLGLHVAHSNETTHLPTA-SNQSHDVYQTTPPAPPTY-SSSL--RA----
AqueK677_Aque_RAF --------------------------R----------------GPLS-PRNP--LT----
AqueK678_Aque_RAF ------------------------------------------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF --DG----------------------------------KL--------------------
KSR2_Hsap_KSR --S---LPPSPRQRHAVRTPPRTPNIVTT---------VT----PPGTPPMRK----KNK
KSR1_Hsap_KSR DTC---IPLHA----SGRLTPRAL--HSF---------IT----PPTTPQLRR----HTK
phl_Dmel_RAF --SL----------------------------------GSQPGSQCG-------------
ksr_Dmel_KSR --------------------------------------PN----SPFTPSSGLSSSLNGT
KSR2_Mmus_KSR --S---LPPSPRQRHVVRTPPRTPNIVTT---------VT----PPGTPPMRR----KNK
KSR1_Mmus_KSR DSC---IPLHT----SGRLTPRAL--HSF---------IT----PPTTPQLRR----HAK
BRAF_Mmus_RAF --AS----------------------------------RN--------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF --AG----------------------------------TS-----DK-------------
ksr-2_Cele_RAF -----------------------------------------------------SSSV--L
ksr-1_Cele_KSR ------------------------------------GFAT--------------------
BRAF_Hsap_RAF --VA----------------------------------RS--------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF --DG----------------------------------KL--------------------
KSR1_Spur_KSR --K---LPP-------------------M---------PT----PPHTPTFNK-------
Raf_Spur_RAF --TN----------------------------------QQ--------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------GGNG--------------------
AqueK676_Aque_KSR -KK----KIGHT-RS-HSNPPLANLIMPEAVPENSVPEYR--------------------
AqueK677_Aque_RAF --VSHSYPLSPV-RHLPPLPPVTVSIEND---------TV----APS-------------
AqueK678_Aque_RAF --------------------------------------------KCT-------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ---TD--P----------------------------------------------------
KSR2_Hsap_KSR L-KPP--G----------------------------------------------------
KSR1_Hsap_KSR L-KPP--R----------------------------------------------------
phl_Dmel_RAF ---TL--T----------------------------------------------------
ksr_Dmel_KSR PQRSR--G----------------------------------------------------
KSR2_Mmus_KSR L-KPP--G----------------------------------------------------
KSR1_Mmus_KSR L-KPP--R----------------------------------------------------
BRAF_Mmus_RAF ---NP--K----------------------------------------------------
ARAF_Mmus_RAF ----E--P----------------------------------------------------
lin-45_Cele_RAF ---EP--P----------------------------------------------------
ksr-2_Cele_RAF PS-TS--S----------------------------------------------------
ksr-1_Cele_KSR ---TP-------------------------------------------------------
BRAF_Hsap_RAF ---NP--K----------------------------------------------------
ARAF_Hsap_RAF ----E--P----------------------------------------------------
RAF1_Mmus_RAF ---TD--S----------------------------------------------------
KSR1_Spur_KSR --RVK--G----------------------------------------------------
Raf_Spur_RAF ---HP--K----------------------------------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ---YP-------------------------------------------------------
AqueK676_Aque_KSR ---SPSPPYYNGHAPPTRTGSHPSIIHNSIANSNQSLANSTSTKSHPQVRRLMAGNYNFS
AqueK677_Aque_RAF ---SP--V----------------------------------------------------
AqueK678_Aque_RAF ---TL--L----------------------------------------------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF -------------S-----KTSNTIRVFLPNKQRTVVNVRNGMSLHDC-LMKALKVRGLQ
KSR2_Hsap_KSR -------------T-----PPPSSRKL-----------------------------IHLI
KSR1_Hsap_KSR -------------T-----PPPPSRKV-----------------------------FQLL
phl_Dmel_RAF -------------R-----QPKILLRAHLPNQQRTSVEVISGVRLCDA-LMKALKLRQLT
ksr_Dmel_KSR -------------------TPPPARKH-----------------------------QTLL
KSR2_Mmus_KSR -------------T-----PPPSSRKL-----------------------------IHLI
KSR1_Mmus_KSR -------------T-----PPPPSRKV-----------------------------FQLL
BRAF_Mmus_RAF -------------S-----PQKPIVRVFLPNKQRTVVPARCGVTVRDS-LKKALMMRGLI
ARAF_Mmus_RAF -------------S-----RAVGTVKVYLPNKQRTVVTVREGMSVYDS-LDKALKVRGLN
lin-45_Cele_RAF -------------K-----FKYKMIMVHLPFDQHSRVEVRPGETARDA-ISKLLKKRNIT
ksr-2_Cele_RAF -------------E-----PPPPASA----------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF -------------S-----PQKPIVRVFLPNKQRTVVPARCGVTVRDS-LKKALMMRGLI
ARAF_Hsap_RAF -------------S-----RAVGTVKVYLPNKQRTVVTVRDGMSVYDS-LDKALKVRGLN
RAF1_Mmus_RAF -------------S-----KTSNTIRVFLPNKQRTVVNVRNGMSLHDC-LMKALKVRGLQ
KSR1_Spur_KSR -------------K-----TPPLTRKT-----------------------------NLPL
Raf_Spur_RAF -------------S-----PLSQSVRAFLPNQQRTSVLAKSGTTLKYC-LSKAMKMRELT
KSR2_Spur_KSR ----------------------------------------------EQ-L----------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR RSISTDLGDVQPDPPLRSNSEASSVQSASPRQRRLSKEVGTSTSMVDLPLIQCSVEQSEF
AqueK677_Aque_RAF -------------T-----THAALIRAHLPEGQRTIVPIRQGVTIQDA-LMKAMKTRNLT
AqueK678_Aque_RAF -------------R-----EKQVLIRAHLPEGQRTIVPIRQGVTIQDA-LMKAMKTRNLT
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF PECCAVFRLLHEHKGKKA-----------------------RLDWNTD--AASLIGEELQ
KSR2_Hsap_KSR PGFTALHRSK---S-HEF-QLGHRVDEAHTPKAKKKSK-----PLNLK--IHSSVGSCEN
KSR1_Hsap_KSR PSFPTLTRSK---S-HES-QLGNRIDDVSS------------------------------
phl_Dmel_RAF PDMCEVSTTH---SG-RH-----------------------IIPWHTD--IGTLHVEEIF
ksr_Dmel_KSR SQ------------------SHVQVDGEQLARNRL------PTDPSPD--SHSSTSSDIF
KSR2_Mmus_KSR PGFTALHRSK---S-HEF-QLGNRVDEANTPKAKKKSK-----PLNLK--IHSGVGSCEN
KSR1_Mmus_KSR PSFPTLTRSK---S-HES-QLGNRIDDVTP------------------------------
BRAF_Mmus_RAF PECCAVYRIQ---DGEKK-----------------------PIGWDTD--ISWLTGEELH
ARAF_Mmus_RAF QDCCVVYRLI---KGRKT-----------------------VTAWDTA--IAPLDGEELI
lin-45_Cele_RAF PQLCHVNASS---DPKQE-S---------------IEL---SLTMEEI--ASRLPGNELW
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF PECCAVYRIQ---DGEKK-----------------------PIGWDTD--ISWLTGEELH
ARAF_Hsap_RAF QDCCVVYRLI---KGRKT-----------------------VTAWDTA--IAPLDGEELI
RAF1_Mmus_RAF PECCAVFRLLQEHKGKKA-----------------------RLDWNTD--AASLIGEELQ
KSR1_Spur_KSR PAQSNWNSDN---H-LNK-RSGPGYDSATLGRIQVRSRDQHTRRYSDDQSVMRLSSPCRS
Raf_Spur_RAF PEMCIVYRVN-----PRM-----------------------ALSWDTD--MMYLAGEEIS
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR PSSSVKSHSV-----PRLAN---------------LTI-------NT------TTGDHNS
AqueK677_Aque_RAF PNTCIVYAE-----SPRL-----------------------LIEWDTD--TTQLSGKEVF
AqueK678_Aque_RAF PNTCIVYAE-----SPRL-----------------------LIEWDTD--TTQLSGKEVF
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF V--------------------------------------------D--------FL-DHV
KSR2_Hsap_KSR IPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIP---R--R
KSR1_Hsap_KSR ----------------------------------------MRFDLSHGSPQMV---R--R
phl_Dmel_RAF V--------------------------------------------R--------LL-DKF
ksr_Dmel_KSR VDPNTNASS---------------------------GGSSSNVLMVPCSPGVG---H--V
KSR2_Mmus_KSR IPAQQRSPLLSERSLRSFFVGHGPFLPSTPPVHTEANFSANTLSVPRWSPQIP---R--R
KSR1_Mmus_KSR ----------------------------------------MKFELPHGSPQLV---R--R
BRAF_Mmus_RAF V--------------------------------------------E--------VL-ENV
ARAF_Mmus_RAF V--------------------------------------------E--------VL-EDV
lin-45_Cele_RAF V------------------------------------------HSE--------YL-NTV
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR -----------------------------------------------KSPKTSS------
BRAF_Hsap_RAF V--------------------------------------------E--------VL-ENV
ARAF_Hsap_RAF V--------------------------------------------E--------VL-EDV
RAF1_Mmus_RAF V--------------------------------------------D--------FL-DHV
KSR1_Spur_KSR EERLTDIGV----------------------------PPKQGKLVPPKSPRAT---H-RS
Raf_Spur_RAF V--------------------------------------------E--------LKAQNF
KSR2_Spur_KSR ---------------------------------------------------------QK-
AqueK675_Aque_KSR -----------------------------------------------QPP--AS------
AqueK676_Aque_KSR T------------------------------------------SVP-TSPRIPTNYNPTG
AqueK677_Aque_RAF V--------------------------------------------E--------YQ-KSP
AqueK678_Aque_RAF V--------------------------------------------V--------VF-MAY
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF P---L---TTHNFARKTFLKLAFCDICQKFL-L----------NGF-----RCQTCGYKF
KSR2_Hsap_KSR DLGNS---IKHRFSTKYWMS-QTCTVCGKGM-L----------FGL-----KCKNCKLKC
KSR1_Hsap_KSR DIGLS---VTHRFSTKSWLS-QVCHVCQKSM-I----------FGV-----KCKHCRLKC
phl_Dmel_RAF PIRTH---IKHQIIRKTFFSLVFCEGCRRLL-F----------TGF-----YCSQCNFRF
ksr_Dmel_KSR GMGHA---IKHRFTKALGF-MATCTLCQKQV-FH---------RWM-----KCTDCKYIC
KSR2_Mmus_KSR DLGNS---IKHRFSTKYWMS-QTCTVCGKGM-L----------FGL-----KCKNCKLKC
KSR1_Mmus_KSR DIGLS---VTHRFSTKSWLS-QVCNVCQKSM-I----------FGV-----KCKHCRLKC
BRAF_Mmus_RAF P---L---TTHNFVRKTFFTLAFCDFCRKLL-F----------QGF-----RCQTCGYKF
ARAF_Mmus_RAF P---L---TMHNFVRKTFFSLAFCDFCLKFL-F----------HGF-----RCQTCGYKF
lin-45_Cele_RAF ---SS---IKHAIVRRTFIPPKSCDVCNNPIWM----------MGF-----RCEFCQFKF
ksr-2_Cele_RAF PPRIS---IYHKMVPSKSK-FRQCDVCEHIF-IFDFVRKQHLDDVY-----ACNVCGIRV
ksr-1_Cele_KSR RLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLG-----------FGFLNAWEKCRSCKWKV
BRAF_Hsap_RAF P---L---TTHNFVRKTFFTLAFCDFCRKLL-F----------QGF-----RCQTCGYKF
ARAF_Hsap_RAF P---L---TMHNFVRKTFFSLAFCDFCLKFL-F----------HGF-----RCQTCGYKF
RAF1_Mmus_RAF P---L---TTHNFARKTFLKLAFCDICQKFL-L----------NGF-----RCQTCGYKF
KSR1_Spur_KSR NMIHA---IKHRFSKKTSMKPQSCDYCHEKIVIL---------QRY-----KCKDCKYIC
Raf_Spur_RAF PAPSS---ISHNFVRKTFFAIAFCDSCQKLL-F----------HGF-----RCQTCSYKF
KSR2_Spur_KSR TLLLR---AKHCYTRQLVSPAKRCDFCKKSMFV----------MTL-----RCKDCRVRC
AqueK675_Aque_KSR PLLHWSTG----------------------------------------------------
AqueK676_Aque_KSR VMGHK---IDHRFINHIFFGVQECDYCKKSMVV----------SGY-----RCRYCKSKF
AqueK677_Aque_RAF KLAST---NHHNFVRKTFIALAFCDVCKKLL-F----------QGF-----RCETCGFRY
AqueK678_Aque_RAF PFLSL---FHHFFVRKTFIALAFCDVCKKLL-F----------QGF-----RCETCGFRY
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF HEHCSTK---VPTMCVDWSN----IRQ---LLLFP-NS-TI---------------GD-S
KSR2_Hsap_KSR HNKCTKE---APP-CHLLIIHRGDPAR---LVRTESVPCDI---------------NN-P
KSR1_Hsap_KSR HNKCTKE---APA-CRISFLPL---TR---LRRTESVPSDI---------------NN-P
phl_Dmel_RAF HQRCANR---VPMLCQPFPMDS--YYQ---LLLAENPDNGV---------------GF-P
ksr_Dmel_KSR HKSCAPH---VPPSCGLPREYV---DE---FRHIKEQGGYA---------------SL-P
KSR2_Mmus_KSR HNKCTKE---APP-CHLLIIHRGDPAR---LVRTESVPCDI---------------NN-P
KSR1_Mmus_KSR HNKCTKE---APA-CRITFLPL---AR---LRRTESVPSDI---------------NN-P
BRAF_Mmus_RAF HQRCSTE---VPLMCVNYDQ----LDL---LFVSKFFE-HH---------------PV-P
ARAF_Mmus_RAF HQHCSSK---VPTVCVDMST----NRR---QFYHSIQD-LS---------------GG-S
lin-45_Cele_RAF HQRCSSF---APLYCDLLQSVP--KNE---DLV---KE-LF---------------GI-A
ksr-2_Cele_RAF HKGCLDR---VKNDCKITTQYM---GG---ILENAVIQS---------------------
ksr-1_Cele_KSR HTQCKGR---VGDSCGLTPDHL---RF---LFDKLIQE-NN---------------GGMW
BRAF_Hsap_RAF HQRCSTE---VPLMCVNYDQ----LDL---LFVSKFFE-HH---------------PI-P
ARAF_Hsap_RAF HQHCSSK---VPTVCVDMST----NRQ---QFYHSVQD-LS---------------GG-S
RAF1_Mmus_RAF HEHCSTK---VPTMCVDWSN----IRQ---LLLFP-NS-TV---------------GD-S
KSR1_Spur_KSR HSNCKFHAEKVPS-CGLPRKYE---EI---FRETINS--AR---------------TD-P
Raf_Spur_RAF HQRCANK---VPTICISTTGDN--LYK---LLLALRKE-D-----------------D-Y
KSR2_Spur_KSR HRRCAQQ---AANLCELAAKHN---------LTTGPES-RN-------------------
AqueK675_Aque_KSR --------------------------------------------------------R---
AqueK676_Aque_KSR HKNCSKL---APPICGLPKYFL---NYARQHFMMSPSH-ESVYQVNKTGHLTSSGEYGSC
AqueK677_Aque_RAF HQRCSPR---VPIQCGGVDDDL--IMA---YILSQ----HP---------------PK-P
AqueK678_Aque_RAF HQRCSPR---VPIQCGGVDDDL--IMA---YILSQ----HP---------------PK-P
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF G-V-----------------------P-ALPS-------L------------------T-
KSR2_Hsap_KSR LRKPPRYSDLHISQTLPKTNKINKD----HIP-------VPYQ---------------P-
KSR1_Hsap_KSR VDR---AAEPHF-GTLPKAL-TKKE----HPP-------AMNH---------------L-
phl_Dmel_RAF G-R-----------------------G-TAVR-------F------------------N-
ksr_Dmel_KSR ----------HVHGAAKGSPLVKKSTL-GKPL-------HQQH---------------G-
KSR2_Mmus_KSR VRKPARYSDLHISQTLPKTNKINKD----HIP-------VPYQ---------------P-
KSR1_Mmus_KSR VDR---AAEPHF-GTLPKAL-TKKE----HPP-------AM-N---------------L-
BRAF_Mmus_RAF Q-E-----------------------E-AS---------F------------------P-
ARAF_Mmus_RAF R-Q-----------------------Q-EAPS-------N--------------------
lin-45_Cele_RAF S-Q-----------------------V-EGPDRSVAEIVL------------------A-
ksr-2_Cele_RAF -------------------NK-KQ--W-EKPT-------TASI---------------SK
ksr-1_Cele_KSR K-D-----------------------PQSVPG-------S--RSMNEPA------FQFP-
BRAF_Hsap_RAF Q-E-----------------------E-AS---------L------------------A-
ARAF_Hsap_RAF R-Q-----------------------H-EAPS-------N--------------------
RAF1_Mmus_RAF G-V-----------------------P-APPS-------F------------------P-
KSR1_Spur_KSR ----------P--------------TV-VN-V-------ASST---------------G-
Raf_Spur_RAF --------------------------N-DYPD----------------------------
KSR2_Spur_KSR V-V-----------------------PT--C-----------------------------
AqueK675_Aque_KSR -----------------------------------------------RV------WSEP-
AqueK676_Aque_KSR N-T-----------------------PT--PS-------S--EQLREETFFIHDLNREP-
AqueK677_Aque_RAF --------------------------D-DS----------------------------P-
AqueK678_Aque_RAF --------------------------D-DS----------------------------P-
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ---------MRRMRES-VS--RMPVSS-----------------QH--RYSTPHAF-TFN
KSR2_Hsap_KSR DSS----S-NPSSTTS-STP-SSPAP----PLP------PSATP----PS-PLHPS-P--
KSR1_Hsap_KSR DSS----S-NPSSTTS-STP-SSPAP----F-P------TSSNP----SSATTPPN-P--
phl_Dmel_RAF ---------MSSRSRSRRCS-SSGSSSSSKPPS------SSSG-NH--R-----------
ksr_Dmel_KSR DSS----S-PSSSCTS-STP-SSPAL----FQQRERELDQAGS--S--SSANLLPT-P--
KSR2_Mmus_KSR DSS----S-NPSSTTS-STP-SSPAP----PLP------PSATP----PS-PLHPS-P--
KSR1_Mmus_KSR DSS----S-NPSSTTS-STP-SSPAP----F-L------TSSNP----SSATTPPN-P--
BRAF_Mmus_RAF ---------ETALPSG-SS--SAPPSDSTGPQI------LTSP-SP--SKSIPIPQ-PFR
ARAF_Mmus_RAF ----------LSVNEL-LTP-QGPSP------------------FT--QQRDQEHF-SF-
lin-45_Cele_RAF ---------NLAPTSG-QSPAATPD--SSHPDL------TSIK-RTGGVKRHPMAVSPQN
ksr-2_Cele_RAF SLT----T-SPTCST--STT-MSPA----------------GVE-----SML--------
ksr-1_Cele_KSR DTA----IDSSSSTNS-SAP-STPAL----PAG------ISGN-----------------
BRAF_Hsap_RAF ---------ETALTSG-SSP-SAPASDSIGPQI------LTSP-SP--SKSIPIPQ-PFR
ARAF_Hsap_RAF ----------RPLNEL-LTP-QGPSP------------------RT--QHCDPEHF-PF-
RAF1_Mmus_RAF ---------MRRMRES-VS--RMPASS-----------------QH--RYSTPHAF-TFN
KSR1_Spur_KSR DSS----S-NPSSTTS-STP-SSPAP----FIS------TSGIPLP--SPSPALPS-P--
Raf_Spur_RAF -------------TFP-DEP-ESPSSDD-------------QD-----------------
KSR2_Spur_KSR ----HAALAEASRRHQ-SAN-STPVPTH-RRKS------STES--F--REIETHQS----
AqueK675_Aque_KSR GGS----SGLSA-SSL-LVD--------------------S-G-----------------
AqueK676_Aque_KSR SKNQFSPVTSTKRPHP-PAP-SSPAHDH-APFS------SSHS--T--SRLEVPQL--FL
AqueK677_Aque_RAF ---------Q---PSS-PVP-HSPT----VPLL----------------------V-PTK
AqueK678_Aque_RAF ---------Q---PSS-PVP-HSPT----VPLL----------------------V-PTK
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF TSSPS--S--------------EGSLSQR-QRSTSTPNVHMVSTTLPV----DSRMIED-
KSR2_Hsap_KSR ------------------------QCTRQ-QKNFNLPASHYYKY----------------
KSR1_Hsap_KSR ------------------------SPGQR-DSRFNFPAAYFIHH----------------
phl_Dmel_RAF ---QG--R--------------PPRISQD-DRSNSAPNVCINN-IRSVTSEVQRSLIM--
ksr_Dmel_KSR ------------------------SLGKHQPSQFNFPNVTVTSS----------------
KSR2_Mmus_KSR ------------------------QCPRQ-KKNFNLPASHYYKY----------------
KSR1_Mmus_KSR ------------------------SPGQR-DSRFSFPAAYFIHH----------------
BRAF_Mmus_RAF PADED--H--------------RNQFGQR-DRSSSAPNVHINT-IEPVN--IDEKFPEV-
ARAF_Mmus_RAF ---PA--P--------------ANPPLQR-IRSTSTPNVHMVSTTAPM----DSSLMQF-
lin-45_Cele_RAF ETSQL--S--------------PSGPYPR-DRSSSAPNINAINDEATVQHN--QRIL-D-
ksr-2_Cele_RAF --------------------------E-------KWNKTKFLKN----------------
ksr-1_Cele_KSR -------------------VSSLTAPYRS-ERKFLFPDTENYS---------VH------
BRAF_Hsap_RAF PADED--H--------------RNQFGQR-DRSSSAPNVHINT-IEPVN--IDDL-----
ARAF_Hsap_RAF ---PA--P--------------ANAPLQR-IRSTSTPNVHMVSTTAPM----DSNLIQL-
RAF1_Mmus_RAF TSSPS--S--------------EGSLSQR-QRSTSTPNVHMVSTTLHV----DSRMIED-
KSR1_Spur_KSR ------------------------SPRMM-VPQFKFPPDVSDDV----------------
Raf_Spur_RAF -------F--------------PRNTLPR-ERSTSAPNICQNAVNVPG----QQ--FDS-
KSR2_Spur_KSR -------------------------TFSV-RRSTTRQRLS--TTTVPK----DHSLGRV-
AqueK675_Aque_KSR -------------------RSSLTSY-GS-QESLLFTSPL--------------------
AqueK676_Aque_KSR PGVRS--HSNYRHPHHHRVPPHSTSSSPS-TSSQSSPCLTPMSPRSPL----DPPV-EYS
AqueK677_Aque_RAF GGDEGETHSR------------FLNTSSR-ERSISTPNVLYNS---PAN--YDPYPTTT-
AqueK678_Aque_RAF GGDEGETHSR------------FLNTSSR-ERSISTPNVLYNS---PAN--YDPYPTTT-
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ---------------AIRSHS----------------------------------E----
KSR2_Hsap_KSR -------------------KQ--QFIFPD-------------------------------
KSR1_Hsap_KSR -------------------RQ--QFIFPVPSA----GHCW--------------------
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR --------------------G----------------GSG--------------------
KSR2_Mmus_KSR -------------------KQ--QFIFPD-------------------------------
KSR1_Mmus_KSR -------------------RQ--QFIFPD-------------------------------
BRAF_Mmus_RAF ---------------ELQDQR--DLI-------RDQGFRGDGAPLNQLMRCLRKYQ----
ARAF_Mmus_RAF ---------------TAQSFS----------------------------------T----
lin-45_Cele_RAF ---------------ALEAQR----L-------E---------------------E----
ksr-2_Cele_RAF -------------------RE--NIC--K-------------------------------
ksr-1_Cele_KSR -----NRLPILVISEGDHPTTT--EI-------Q---------------------QE---
BRAF_Hsap_RAF -------------------------I-------RDQGFRGDGAPLNQLMRCLRKYQ----
ARAF_Hsap_RAF ---------------TGQSFS----------------------------------T----
RAF1_Mmus_RAF ---------------AIRSHS----------------------------------E----
KSR1_Spur_KSR --------------------S---------------------------------------
Raf_Spur_RAF -----------------EAFS--RFAFPVKSSLN---------P---------NGH----
KSR2_Spur_KSR ---------------SRSTLSSQSSN-------R---------------------SSVSG
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR GFNSLHRSIAIVLSTDDNTSSTDEEG-------D---------------------GPDGE
AqueK677_Aque_RAF -----------------EDNR--EFLGPMPF-------SS-------------VSG----
AqueK678_Aque_RAF -----------------EDNR--EFLGPMPF-------SS-------------VSG----
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF -------SASPS------------------------------------------A-----
KSR2_Hsap_KSR --------------------------------------------VVPVPETPTRAPQV--
KSR1_Hsap_KSR ----------KCL-LIA--------------ESLKEN-AFN---ISAFAH---AAP----
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR ----------GVS-LIS--------------NE-------------PVPEQFPTAPAT--
KSR2_Mmus_KSR --------------------------------------------VVPVPETPTRAPQV--
KSR1_Mmus_KSR --------------------------------------------ISACSQ---AAP----
BRAF_Mmus_RAF -------SRTPSP-LLH--------------SVPSEI-VFD-FEPGPVFRGSTTG--L--
ARAF_Mmus_RAF -------DAAG-----------------------------------------RG---G--
lin-45_Cele_RAF -------ESR----------------------------------------DKT-------
ksr-2_Cele_RAF --------------------------------------------IE--------------
ksr-1_Cele_KSR ----TEN-------------------HNK----------------S--------A--AA-
BRAF_Hsap_RAF -------SRTPSP-LLH--------------SVPSEI-VFD-FEPGPVFRGSTTG--L--
ARAF_Hsap_RAF -------DAAGS----------------------------------------RGG--S--
RAF1_Mmus_RAF -------SASPS------------------------------------------A-----
KSR1_Spur_KSR -------------------------------------------------E----------
Raf_Spur_RAF -------TASAAV-NIHGAHGGGHGKVLTPNSAVQDG-VFD-YDPTNIANDGHTA--SAA
KSR2_Spur_KSR Y-YS---QESDASLLS-------------ECDTPKEISVFDSFGPG--------D--VT-
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR FYEGSEGFTSDSSNSSFNEVGLVGPAHNRGLKLP------------------------S-
AqueK677_Aque_RAF -------SYVDNH-LSH--------------STEYNS-VFD-YNVSSSGNSSRDA--PIA
AqueK678_Aque_RAF -------SYVDNH-LSH--------------STEYNS-VFD-YNVSSSGNSSRDA--PIA
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR ------------------------------------------------------------
KSR1_Hsap_KSR ------------------------------------------------------------
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR ----------------------ANGGLDS-------------------------------
KSR2_Mmus_KSR ------------------------------------------------------------
KSR1_Mmus_KSR ------------------------------------------------------------
BRAF_Mmus_RAF ------------------------------------------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF ------------------------------------------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF VNIHGAH---GG-------------------------GHGK-------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------RGIA--------------------------------
AqueK677_Aque_RAF HPPHSRRGLCGRGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKERR
AqueK678_Aque_RAF HPPHSRRGLCGRGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKERR
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR -------------------------------------------------------I----
KSR1_Hsap_KSR ------------------------------------------------------------
phl_Dmel_RAF ------------------------------------------QAR---------------
ksr_Dmel_KSR --------------------------------------------LVSSSNGHMSSLIGSQ
KSR2_Mmus_KSR -------------------------------------------------------I----
KSR1_Mmus_KSR ------------------------------------------------------------
BRAF_Mmus_RAF ------------------------------------------SAT---------------
ARAF_Mmus_RAF ------------------------------------------DGA---------------
lin-45_Cele_RAF ----------GSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCT---------------
ksr-2_Cele_RAF -------------------------------------------------NVHK-------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF ------------------------------------------SAT---------------
ARAF_Hsap_RAF ------------------------------------------DGT---------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR -------------------------------------------------------FLDNN
Raf_Spur_RAF ------------------------------------------VLT---------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------------------------------------------
AqueK677_Aque_RAF NSTEGRSPMERRLHSSSERHRHRSLERRS-------------SSG---------------
AqueK678_Aque_RAF NSTEGRSPMERRLHSSSERHRHRSLERRS-------------SSG---------------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ---------------------------------------------------LSSSPN-N-
KSR2_Hsap_KSR ---------LHPV----TSNP---------------------------------------
KSR1_Hsap_KSR ---------LPEA----ADGT---------------------------------------
phl_Dmel_RAF ---------------------PP-----------------------------LPHPCTD-
ksr_Dmel_KSR TSNASTAATLTGSLVNSTTTTST----------------------------CSFFPR-K-
KSR2_Mmus_KSR ---------LHPV----TSNT---------------------------------------
KSR1_Mmus_KSR ---------LSST----ADST---------------------------------------
BRAF_Mmus_RAF ---------------------PP-----------------------------ASLPG-S-
ARAF_Mmus_RAF ---------------------PR----------------------------GSPSPA-S-
lin-45_Cele_RAF ---------------------PL----------------------------GSNSPS-S-
ksr-2_Cele_RAF ------------T-------------------------------------------R-K-
ksr-1_Cele_KSR -----------------------------------------------------SMSG-N-
BRAF_Hsap_RAF ---------------------PP-----------------------------ASLPG-S-
ARAF_Hsap_RAF ---------------------PR----------------------------GSPSPA-S-
RAF1_Mmus_RAF ---------------------------------------------------LSSSPN-N-
KSR1_Spur_KSR -E-----------NVTSTSSD-----------------------------------R-T-
Raf_Spur_RAF ---------------------PNSAVQDGVFDYDPTNIANGLASSLPNTRNLIHSPK-R-
KSR2_Spur_KSR ----------------------------------------------------SPIPS-S-
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ---------------------------------------------------AQSLPN-LL
AqueK677_Aque_RAF ---------------------DR----------------------------TSATPD-S-
AqueK678_Aque_RAF ---------------------DR----------------------------TSATPD-S-
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF --LSP-------------------------------------------------------
KSR2_Hsap_KSR -----------------ILEG---------------------------------------
KSR1_Hsap_KSR -----------------RLDD---------------------------------------
phl_Dmel_RAF --HSN-------------------------------------------------------
ksr_Dmel_KSR --LST-----------AGVDK----------------------------R----------
KSR2_Mmus_KSR -----------------ILEG---------------------------------------
KSR1_Mmus_KSR -----------------RLDD---------------------------------------
BRAF_Mmus_RAF --LTN-------------------------------------------------------
ARAF_Mmus_RAF --VS--------------------------------------------------------
lin-45_Cele_RAF --TCS---SPPGGLIGQPTLGQ------SPNVSGSTTSSLVAAHLHTLPLTPPQS-----
ksr-2_Cele_RAF --L---------------------------------------------------------
ksr-1_Cele_KSR --IES-------------------------------------------------------
BRAF_Hsap_RAF --LTN-------------------------------------------------------
ARAF_Hsap_RAF --VS--------------------------------------------------------
RAF1_Mmus_RAF --LSP-------------------------------------------------------
KSR1_Spur_KSR --I---------------------------------------------------------
Raf_Spur_RAF --ESG-------------------------------------------------------
KSR2_Spur_KSR --SRSRRHE-----------AW------AA------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR MAERRQSRG-----------GGANGEGLYA------------------------------
AqueK677_Aque_RAF --MSP-----------SYSTGQ------SPL------------------QTPTGSKPPLQ
AqueK678_Aque_RAF --MSP-----------SYSTGQ------SPL------------------QTPTGSKPPLQ
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF --------------T-------------------------------------G-WSQPKT
KSR2_Hsap_KSR --------------NPL-------------------------------------LQIEVE
KSR1_Hsap_KSR --------------QPK-AD--------------------------------V-LEAHEA
phl_Dmel_RAF --------------S-------------------------------------T-QASPTS
ksr_Dmel_KSR --------------TPFTSE--------------------------------Y-TDTHKS
KSR2_Mmus_KSR --------------NPL-------------------------------------LQIEVE
KSR1_Mmus_KSR --------------QPK-TD--------------------------------V-LGVHEA
BRAF_Mmus_RAF ----------------------------------------------------V-KALQKS
ARAF_Mmus_RAF --------------S-------------------------------------G-RKSPHS
lin-45_Cele_RAF -------------------------------------------------------APPQK
ksr-2_Cele_RAF ------------------------------------------------------ISMTTS
ksr-1_Cele_KSR ---------------------------------------------------EGTIVANHE
BRAF_Hsap_RAF ----------------------------------------------------V-KALQKS
ARAF_Hsap_RAF --------------S-------------------------------------G-RKSPHS
RAF1_Mmus_RAF --------------T-------------------------------------G-WSQPKT
KSR1_Spur_KSR -----------------TV------------------------------------DSHDT
Raf_Spur_RAF ----------------------------------------------------S-HSSQPS
KSR2_Spur_KSR --------------T----K--PAPTSTYMDCPAHGNCESGAETNLMMSLDGGSLVATWP
AqueK675_Aque_KSR -------------------------------------------------------ATDSD
AqueK676_Aque_KSR --------------T----SEDNLQSWYD-RKPSLSGTISTADSKT-STL-VGSIMEGSD
AqueK677_Aque_RAF TSLSSGDSGLGGSRS-------------------------------------S-TSYSSS
AqueK678_Aque_RAF TSLSSGDSGLGGSRS-------------------------------------S-TSYSSS
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF PV---------PA-----Q-RERAP--VS-GT-QEK------------NK----------
KSR2_Hsap_KSR PT---------S-----EN-EEVH-DEAE-ES-EDDFEEMNLSLLSAR-S----------
KSR1_Hsap_KSR EA---------E-----EP-EAGK-SEAE-DD-EDEVDDLPSSRRPWRGP----------
phl_Dmel_RAF TL---------KH-----N-RPRAR---S-AD-ESN------------KN----------
ksr_Dmel_KSR ND---------S-----DK-TVSLSGSASTDSDRTPVRVDS-TEDGDS------------
KSR2_Mmus_KSR PT---------S-----EN-EESH-NEAE-ES-EDEFEEMNLSLLSAR-S----------
KSR1_Mmus_KSR EA---------E-----EP-EAGK-SEAE-DDEEDEVDDLPSSRRPWRGP----------
BRAF_Mmus_RAF -----------PG----PQ-RERKSSSSS-SS-EDR------------SR----------
ARAF_Mmus_RAF KL---------PS----EQ-RERK----S-LA-DEK------------KK----------
lin-45_Cele_RAF IS---------PG----FF-RNRSR--SP-GE-RLD------------AQ----------
ksr-2_Cele_RAF TL---------D-----DV-TTFN-SEIN-EE-MDE------------------------
ksr-1_Cele_KSR DS---------T-GSQEVD-SE--AAPSQ-EA-VDK------------FNKRADGGFTWE
BRAF_Hsap_RAF -----------PG----PQ-RERKS--SS-SS-EDR------------NR----------
ARAF_Hsap_RAF KS---------PA----EQ-RERK----S-LA-DDK------------KK----------
RAF1_Mmus_RAF PV---------PA-----Q-RERAP--GS-GT-QEK------------NK----------
KSR1_Spur_KSR HD---------P------F-TD---SERTLPEQVEPVDEVS-DPEPNILL----------
Raf_Spur_RAF -----------PT----HQPRWKDVLPGS-DS-KD-------------NK----------
KSR2_Spur_KSR QDRKCNCCPHIPENNCNSN-DQM-VSDWT-EE-YRR------------SS----------
AqueK675_Aque_KSR VF---------S-DCYTDD-EE--EEEEE-DE-IEE------------VP----------
AqueK676_Aque_KSR DDD----------DSYADS-EGVGSSGGL-DE-PEV------------NK----------
AqueK677_Aque_RAF TL---------PS-----Q-RRRQR---T-SS-EDK------------RA----------
AqueK678_Aque_RAF TL---------PS-----Q-RRRQR---T-SS-EDK------------RA----------
AqueK679_Aque_RAF ------------------------------------------------------------
RAF1_Hsap_RAF ------I--------RP--R--GQRDSSYYWEIEASEVML---STRIGSGSFGTVYKGKW
KSR2_Hsap_KSR ------F--------PR--KASQTSIFLQEWDIPFEQLEI---GELIGKGRFGQVYHGRW
KSR1_Hsap_KSR ------I--------SR--KASQTSVYLQEWDIPFEQVEL---GEPIGQGRWGRVHRGRW
phl_Dmel_RAF ------L--------LL--R--DAKSSEENWNILAEEILI---GPRIGSGSFGTVYRAHW
ksr_Dmel_KSR ------G--------QW--R--QNSISLKEWDIPYGDLLL---LERIGQGRFGTVHRALW
KSR2_Mmus_KSR ------F--------PR--KASQTSIFLQEWDIPFEQLEI---GELIGKGRFGQVYHGRW
KSR1_Mmus_KSR ------I--------SR--KASQTSVYLQEWDIPFEQVEL---GEPIGQGRWGRVHRGRW
BRAF_Mmus_RAF ------M--------KT--L--GRRDSSDDWEIPDGQITV---GQRIGSGSFGTVYKGKW
ARAF_Mmus_RAF ------V--------KN--L--GYRDSGYYWEVPPSEVQL---LKRIGTGSFGTVFRGRW
lin-45_Cele_RAF ------R--------PR--P--PQKPHHEDWEILPNEFII---QYKVGSGSFGTVYRGEF
ksr-2_Cele_RAF -------------------E--TVLMTWEDVTIKLTDVDV---MTKIGDGRFGSVYFGGY
ksr-1_Cele_KSR RHAWNMS--------TIRGP--NAQASWNEVTIQFETIEFDKQAPIIGRGRFGKVLRGFH
BRAF_Hsap_RAF ------M--------KT--L--GRRDSSDDWEIPDGQITV---GQRIGSGSFGTVYKGKW
ARAF_Hsap_RAF ------V--------KN--L--GYRDSGYYWEVPPSEVQL---LKRIGTGSFGTVFRGRW
RAF1_Mmus_RAF ------I--------RP--R--GQRDSSYYWEIEASEVML---STRIGSGSFGTVYKGKW
KSR1_Spur_KSR ------A--------TR--K--NSQKLLSEWDIPFEQLEI---LDLIGTGRFGAVH----
Raf_Spur_RAF ------IKPPTTLLGHR--R--TRRDSNDDWEIPTEEIRL---GSRIGAGSFGTVFSGQW
KSR2_Spur_KSR ------L--------HY--E--AQKEGLSEWTIPHANLKY---GRCIEKGKLGSTYKGHW
AqueK675_Aque_KSR ------L--------SV-----YLQGKWKEWMVGSEEIQL---YGEAASSCKETVQKGYW
AqueK676_Aque_KSR ------Y--------RI--R--HRNSVVDEWIIPYNDLKL---LEKLGSGPVAEVYKGYW
AqueK677_Aque_RAF ----------------K--V--KCKDSSDVWEIPYNEIEV---GERIGSGSFGTVYKGKW
AqueK678_Aque_RAF ------L--------QK--V--KCKDSSDVWEIPYNEIEV---GERIGSGSFGTVYKGKW
AqueK679_Aque_RAF --------------------------------FKFRQVT--ILKETLGNGAYGVVYKAKC
. . . .
RAF1_Hsap_RAF HGDVA-VKILKV------VDPTP--EQFQAFRNEV-AVLRKTRHVNILLFMGYM-TKD--
KSR2_Hsap_KSR HGEVA-IRLIDI------ERDNE--DQLKAFKREV-MAYRQTRHENVVLFMGACMSPP--
KSR1_Hsap_KSR HGEVA-IRLLEM------DGHNQ--DHLKLFKKEV-MNYRQTRHENVVLFMGACMNPP--
phl_Dmel_RAF HGPVA-VKTLNV------KTPSP--AQLQAFKNEV-AMLKKTRHCNILLFMGCV-SKP--
ksr_Dmel_KSR HGDVA-VKLLNE------DYLQDE-HMLETFRSEV-ANFKNTRHENLVLFMGACMNPP--
KSR2_Mmus_KSR HGEVA-IRLIDI------ERDNE--DQLKAFKREV-MAYRQTRHENVVLFMGACMSPP--
KSR1_Mmus_KSR HGEVA-IRLLEM------DGHNQ--DHLKLFKKEV-MNYRQTRHENVVLFMGACMNPP--
BRAF_Mmus_RAF HGDVA-VKMLNV------TAPTP--QQLQAFKNEV-GVLRKTRHVNILLFMGYS-TKP--
ARAF_Mmus_RAF HGDVA-VKVLKV------AQPTA--EQAQAFKNEM-QVLRKTRHVNILLFMGFM-TRP--
lin-45_Cele_RAF FGTVA-IKKLNV------VDPTP--SQMAAFKNEV-AVLKKTRHLNVLLFMGWV-REP--
ksr-2_Cele_RAF HGNAA-VRFVNM------NYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYV-SDPVT
ksr-1_Cele_KSR YGDVA-VKVYTM------EHISDASKKAEEFKLEV-SAYKNTRHDNIALFLGYFMSDG--
BRAF_Hsap_RAF HGDVA-VKMLNV------TAPTP--QQLQAFKNEV-GVLRKTRHVNILLFMGYS-TKP--
ARAF_Hsap_RAF HGDVA-VKVLKV------SQPTA--EQAQAFKNEM-QVLRKTRHVNILLFMGFM-TRP--
RAF1_Mmus_RAF HGDVA-VKILKV------VDPTP--EQLQAFRNEV-AVLRKTRHVNILLFMGYM-TKD--
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF HGSVA-VKRLNV------KDPTP--SQLQAFKNEV-AVLRKTRHANILLFMGCT-SKP--
KSR2_Spur_KSR HGEVL-IQTR---------YSKS--TDINDFLDEV-AMLSKIRHENIALFMGACVEPG--
AqueK675_Aque_KSR HGNVW-VHQRTI------K--RQ--EDVRSFANEV-NTLCCIRHENIQLFMGVCLDLPAG
AqueK676_Aque_KSR HGEVA-VKRFVL------PNATP--KQINKFREEV-AVLKKIRHENLALFMGVCLTTP--
AqueK677_Aque_RAF HGPVA-VKKLNV------SNPTE--QQMQAFKNEV-AVLMKTRHANILLFMGWT-SKP--
AqueK678_Aque_RAF HGPVA-VKKLNV------SNPTE--QQMQAFKNEV-AVLMKTRHANILLFMGWT-SKP--
AqueK679_Aque_RAF DELICAAKYMHPIFFALSEDPAVNVVATDKFKKEC-QLLSRLKHPNIVQYLGTH-EVN--
RAF1_Hsap_RAF -NLAIVTQWC--EGS-SLYKHLHVQ-ET--KFQMFQLIDIARQTAQGMDYLHAKNIIHRD
KSR2_Hsap_KSR -HLAIITSLC--KGR-TLYSVVRDA-KI--VLDVNKTRQIAQEIVKGMGYLHAKGILHKD
KSR1_Hsap_KSR -HLAIITSFC--KGR-TLHSFVRDP-KT--SLDINKTRQIAQEIIKGMGYLHAKGIVHKD
phl_Dmel_RAF -SLAIVTQWC--EGS-SLYKHVHVS-ET--KFKLNTLIDIGRQVAQGMDYLHAKNIIHRD
ksr_Dmel_KSR -YLAIVTSLC--KGN-TLYTYIHQR-RE--KFAMNRTLLIAQQIAQGMGYLHAREIIHKD
KSR2_Mmus_KSR -HLAIITSLC--KGR-TLYSVVRDA-KI--VLDVNKTRQIAQEIVKGMGYLHAKGILHKD
KSR1_Mmus_KSR -HLAIITSFC--KGR-TLHSFVRDP-KT--SLDINKTRQIAQEIIKGMGYLHAKGIVHKD
BRAF_Mmus_RAF -QLAIVTQWC--EGS-SLYHHLHII-ET--KFEMIKLIDIARQTAQGMDYLHAKSIIHRD
ARAF_Mmus_RAF -GFAIITQWC--EGS-SLYHHLHVA-DT--RFDMVQLIDVARQTAQGMDYLHAKNIIHRD
lin-45_Cele_RAF -EIAIITQWC--EGS-SLYRHIHVQ-EPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRD
ksr-2_Cele_RAF NTYAIVTNFY--QHN-TLYHRIHEQLSE--DFDQSWTFQISLQICQAMSYLHKKKILHRD
ksr-1_Cele_KSR -QYGMVMSLS--KGSQSLYTLLHVV-RE--KLDLATTRKIAQQICQAVSYLHTKKILHKD
BRAF_Hsap_RAF -QLAIVTQWC--EGS-SLYHHLHII-ET--KFEMIKLIDIARQTAQGMDYLHAKSIIHRD
ARAF_Hsap_RAF -GFAIITQWC--EGS-SLYHHLHVA-DT--RFDMVQLIDVARQTAQGMDYLHAKNIIHRD
RAF1_Mmus_RAF -NLAIVTQWC--EGS-SLYKHLHVQ-ET--KFQMFQLIDIARQTAQGMDYLHAKNIIHRD
KSR1_Spur_KSR -------NLC--KGQ-TLYTHIHLR-KD--RFNINRTIQIATQITQGMSYLHHKGIVHKD
Raf_Spur_RAF -QLAIVTQWC--EGS-SLYKHLHVL-DT--KLVMHQLIDISRQTAQGMDYLHAKNIIHRD
KSR2_Spur_KSR -NLAVVNSIH--KGP-SLYHHLHVQ-RR--KLQTSSKMDIARQIGQAMGYLQAKGIIVGH
AqueK675_Aque_KSR DTFGIIMSEV--KGD-TLYNHIHKL-GH--NFTTPSKLKILRQISEGMEYLHAKGIQHGG
AqueK676_Aque_KSR -NLAIITSYC--KGY-TLYKLLHYW-SE--AFSLERLANIGRQIAQAMGYLHARGIIHKG
AqueK677_Aque_RAF -RLTIVTQWC--DGS-TLFSHIHVL-ED--RFEMYKIIDICRQTAQGVDYLHAKQIIHRD
AqueK678_Aque_RAF -RLTIVTQWC--DGS-TLFSHIHVL-ED--RFEMYKIIDICRQTAQGVDYLHAKQIIHRD
AqueK679_Aque_RAF -GIDTVVLLMELMDS-SLHAYLHAHVDS--PLPFHQEINISLDVARALDYLHVNNIHHRD
:*. :: : : : .: **: . *
RAF1_Hsap_RAF MKSNNIFLHE---GL-TVKIGDFGLATVKSRW---SGS--QQVEQ--PTGSVLWMAPEVI
KSR2_Hsap_KSR LKSKNVFYDN---G--KVVITDFGLFSISGVLQAGR--REDKLRI--QNGWLCHLAPEII
KSR1_Hsap_KSR LKSKNVFYDN---G--KVVITDFGLFGISGVVREGR--RENQLKL--SHDWLCYLAPEIV
phl_Dmel_RAF LKSNNIFLHE---DL-SVKIGDFGLATAKTRW---SGE--KQANQ--PTGSILWMAPEVI
ksr_Dmel_KSR LRTKNIFIEN---G--KVIITDFGLFSSTKLLYC-----DMGLGV--PHNWLCYLAPELI
KSR2_Mmus_KSR LKSKNVFYDN---G--KVVITDFGLFSISGVLQAGR--RDDKLRI--QNGWLCHLAPEII
KSR1_Mmus_KSR LKSKNVFYDN---G--KVVITDFGLFGISGVVREER--RENQLKL--SHDWLCYLAPEIV
BRAF_Mmus_RAF LKSNNIFLHE---DL-TVKIGDFGLATVKSRW---SGS--HQFEQ--LSGSILWMAPEVI
ARAF_Mmus_RAF LKSNNIFLHE---GL-TVKIGDFGLATVKTRW---SGA--QPLEQ--PSGSVLWMAAEVI
lin-45_Cele_RAF LKTNNIFLMD---DMSTVKIGDFGLATVKTKWTV-NGG--QQQQQ--PTGSILWMAPEVI
ksr-2_Cele_RAF LRTKNILLDN---PN-RVVVTDFALMKLERLEN-PR--RNCTLLI--PNHWIDYLSPEIA
ksr-1_Cele_KSR LRSKNILLES---KN-KVVITDFGILSMKRLA-HP--KQ--KSGYLTSKFWTNYIAPELA
BRAF_Hsap_RAF LKSNNIFLHE---DL-TVKIGDFGLATVKSRW---SGS--HQFEQ--LSGSILWMAPEVI
ARAF_Hsap_RAF LKSNNIFLHE---GL-TVKIGDFGLATVKTRW---SGA--QPLEQ--PSGSVLWMAAEVI
RAF1_Mmus_RAF MKSNNIFLHE---GL-TVKIGDFGLATVKSRW---SGS--QQVEQ--PTGSVLWMAPEVI
KSR1_Spur_KSR LKSKNIFIEN---G--KVVLTDFALFSIGRLSKQKT--RKDSLVI--PDGWLCYLAPELI
Raf_Spur_RAF LKSNNIFLHD---DL-TVKIGDFGLATVKSRW---SGS--QQFEQ--PSGSILWMAPEVI
KSR2_Spur_KSR LSSRCVYLES---KV-KLSVTRVDTSDVTC-----QRA--SHACL--PRGKLQYLAPELL
AqueK675_Aque_KSR LSSKLVTINH---RV-CISL-SF----------HN--TN--NRQLEG--CDLPYLTPEEI
AqueK676_Aque_KSR LNTKNIFLEKRDQKE-KVIITDMGLSSLSSLLYDNTTSKGGVVTF--PRAQLYSLAPEII
AqueK677_Aque_RAF LKSNNIFLHD---DM-TVKIGDFGLATVKTRW---DGN--EKVRQ--PTGSILWMAPEVI
AqueK678_Aque_RAF LKSNNIFLHD---DM-TVKIGDFGLATVKTRW---DGN--EKVRQ--PTGSILWMAPEVI
AqueK679_Aque_RAF LSAKNILMLG---DY-RAKVSDFGQSKLRNPNG---GF--SSNSP--CPGNILYMPPETL
: :. : : . :..*
RAF1_Hsap_RAF RMQ-----------DNNP--FSFQSDVYSYGIVLYELMTGELPYSHIN-----NRDQIIF
KSR2_Hsap_KSR RQLSPDT-----EEDKLP--FSKHSDVFALGTIWYELHAREWPFKTQ------PAEAIIW
KSR1_Hsap_KSR REMTPGK-----DEDQLP--FSKAADVYAFGTVWYELQARDWPLKNQ------AAEASIW
phl_Dmel_RAF RMQ-----------ELNP--YSFQSDVYAFGIVMYELLAECLPYGHIS-----NKDQILF
ksr_Dmel_KSR RALQPEKP----RGECLE--FTPYSDVYSFGTVWYELICGEFTFKDQ------PAESIIW
KSR2_Mmus_KSR RQLSPDT-----EEDKLP--FSKHSDVFALGTIWYELHAREWPFKTQ------PAEAIIW
KSR1_Mmus_KSR REMIPGR-----DEDQLP--FSKAADVYAFGTVWYELQARDWPFKHQ------PAEALIW
BRAF_Mmus_RAF RMQ-----------DKNP--YSFQSDVYAFGIVLYELMTGQLPYSNIN-----NRDQIIF
ARAF_Mmus_RAF RMQ-----------DPNP--YSFQSDVYAYGVVLYELMTGSLPYSHIG-----SRDQIIF
lin-45_Cele_RAF RMQ-----------DDNP--YTPQSDVYSFGICMYEILSSHLPYSNIN-----NRDQILF
ksr-2_Cele_RAF GNLMIDWRGDVLFQHELP--FSQESDVYSFGTIFFELLLRRMPTGCD------SWDQKLY
ksr-1_Cele_KSR MAMRTEYDE--YECDDFP--FSENSDVYAFGCVWFEMLTGALPYAGEL------PHQILF
BRAF_Hsap_RAF RMQ-----------DKNP--YSFQSDVYAFGIVLYELMTGQLPYSNIN-----NRDQIIF
ARAF_Hsap_RAF RMQ-----------DPNP--YSFQSDVYAYGVVLYELMTGSLPYSHIG-----CRDQIIF
RAF1_Mmus_RAF RMQ-----------DDNP--FSFQSDVYSYGIVLYELMAGELPYAHIN-----NRDQIIF
KSR1_Spur_KSR TSLKINTDG--TQDMELP--FSEKSDVYSFGTIWYELLAGEWPFHKQ------PVETVIW
Raf_Spur_RAF RMR-----------DTNP--YSFQSDVYAFGVVLFELVTQSLPYQNIK-----HKDQIIW
KSR2_Spur_KSR AKARVVPPE---FITGNE--QTHSTDVYAFGTILFEIIAGRWPLQYAC------SESVIY
AqueK675_Aque_KSR RSITQLSNG--YLFLPTK--PTPSTDIFAFGTIAYELTTLKLPFLNQS------LLDLIW
AqueK676_Aque_KSR RKISPTPVV---QIDQEPYSYNYATDVYAFGTILYELITKRFPFSTDSLGFAYEFEVVIF
AqueK677_Aque_RAF RME-----------EPDP--YTFYCDVYSFGVVVYELISGQLPYPHVQ-----DRDQILF
AqueK678_Aque_RAF RME-----------EPDP--YTFYCDVYSFGVVVYELISGQLPYPHVQ-----DRDQILF
AqueK679_Aque_RAF KVP---------------PDFAPTLDEFSFGIVTIQIMSRKDPKPSD-----LHRTG--S
* :: * :: .
RAF1_Hsap_RAF MVGRG--YASPDLSKLYKNC-----PKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS
KSR2_Hsap_KSR QMGTG--M-KPNLSQ--IGM-----GKEISDILLFCWAFEQEERPTFTKLMDMLEK----
KSR1_Hsap_KSR QIGSGEGM-KRVLTS--VSL-----GKEVSEILSACWAFDLQERPSFSLLMDMLEK----
phl_Dmel_RAF MVGRG--LLRPDMSQVRSDA-----PQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRT
ksr_Dmel_KSR QVGRG--M-KQSLAN--LQS-----GRDVKDLLMLCWTYEKEHRPQFARLLSLLEH----
KSR2_Mmus_KSR QMGTG--M-KPNLSQ--IGM-----GKEISDILLFCWAFEQEERPTFTKLMDMLEK----
KSR1_Mmus_KSR QIGSGEGV-RRVLAS--VSL-----GKEVGEILSACWAFDLQERPSFSLLMDMLER----
BRAF_Mmus_RAF MVGRG--YLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPLFPQILASIELLARS
ARAF_Mmus_RAF MVGRG--YLSPDLSKIFSNC-----PKAMRRLLTDCLKFQREERPLFPQILATIELLQRS
lin-45_Cele_RAF MVGRG--YLRPDRSKIRHDT-----PKSMLKLYDNCIMFDRNERPVFGEVLERLRDI--I
ksr-2_Cele_RAF AKMCGQKAALQRLDAQLQKI-----DGKLHELLLECWSSQPEKRPSFQQIVKRITV---Q
ksr-1_Cele_KSR AKTQG--IR-PVLPNV--KC-----TQELKELLVSCWNTAPQDRPTLTDINLKLTALP-K
BRAF_Hsap_RAF MVGRG--YLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPLFPQILASIELLARS
ARAF_Hsap_RAF MVGRG--YLSPDLSKISSNC-----PKAMRRLLSDCLKFQREERPLFPQILATIELLQRS
RAF1_Mmus_RAF MVGRG--YASPDLSRLYKNC-----PKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS
KSR1_Spur_KSR QVGKG--L-KQPLNH--LQA-----SRDVKEILMMCWSYSPDSRPIFQHIKKTILR----
Raf_Spur_RAF MVGRG--YLQPDLSKVRNDT-----PKALKRLITDCYALNRDERPLFPVVLAALESLARQ
KSR2_Spur_KSR QTCSG--RR-DDFRNV--TC-----SSTMKNLIQECWSQNPNERPSFQDIVKELKKN-VS
AqueK675_Aque_KSR SVGNN--GH-QSLKLL--P------RSCFRSVIHRCWSH--TRRTTFKDILSSIQDNT-S
AqueK676_Aque_KSR LVGHG--HR-QPFK-G--ET-----PKKLKDIVWECWSHQPQDRPPFSDLQERLARLCRK
AqueK677_Aque_RAF MVGRG--FLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPLFHQILADLESLSDS
AqueK678_Aque_RAF MVGRG--FLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPLFHQVYNNLESLSDS
AqueK679_Aque_RAF LIGTLV--EVPEIERRRDDIDSCDPSNPILGLSISCISNDPQERPPIERMCQLLSLLKNT
. : * *. : : :
RAF1_Hsap_RAF LP----------------------------------------------------------
KSR2_Hsap_KSR LP----------------------------------------------------------
KSR1_Hsap_KSR LP----------------------------------------------------------
phl_Dmel_RAF LP----------------------------------------------------------
ksr_Dmel_KSR LPKK--------------------------------------------------------
KSR2_Mmus_KSR LP----------------------------------------------------------
KSR1_Mmus_KSR LP----------------------------------------------------------
BRAF_Mmus_RAF LP----------------------------------------------------------
ARAF_Mmus_RAF LP----------------------------------------------------------
lin-45_Cele_RAF LP----------------------------------------------------------
ksr-2_Cele_RAF MPRKE-------------------------------------------------------
ksr-1_Cele_KSR KP----------------------------------------------------------
BRAF_Hsap_RAF LP----------------------------------------------------------
ARAF_Hsap_RAF LP----------------------------------------------------------
RAF1_Mmus_RAF LP----------------------------------------------------------
KSR1_Spur_KSR LPKKK-------------------------------------------------------
Raf_Spur_RAF LP----------------------------------------------------------
KSR2_Spur_KSR LG----------------------------------------------------------
AqueK675_Aque_KSR FPP---------------------------------------------------------
AqueK676_Aque_KSR HT----------------------------------------------------------
AqueK677_Aque_RAF MP----------------------------------------------------------
AqueK678_Aque_RAF MP----------------------------------------------------------
AqueK679_Aque_RAF -SQYKKSAMGLSSSSDEGKENVHPFEDYGEVLIVELNENDTHYSSKIDDLTRTIKDKENL
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR ------------------------------------------------------------
KSR1_Hsap_KSR ------------------------------------------------------------
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR ------------------------------------------------------------
KSR2_Mmus_KSR ------------------------------------------------------------
KSR1_Mmus_KSR ------------------------------------------------------------
BRAF_Mmus_RAF ------------------------------------------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF ------------------------------------------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF ------------------------------------------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------------------------------------------
AqueK677_Aque_RAF ------------------------------------------------------------
AqueK678_Aque_RAF ------------------------------------------------------------
AqueK679_Aque_RAF LKDQSNILELRNKQLLQKSNIIDKYKLQLEEKESEDAEADKKKSQLEIYNLELETKVSEL
RAF1_Hsap_RAF --KINRSASE--------------------------------------------------
KSR2_Hsap_KSR --KRNRRLSH--------------------------------------------------
KSR1_Hsap_KSR --KLNRRLSH--------------------------------------------------
phl_Dmel_RAF --KIHRSASE--------------------------------------------------
ksr_Dmel_KSR --RLARSPSH--------------------------------------------------
KSR2_Mmus_KSR --KRNRRLSH--------------------------------------------------
KSR1_Mmus_KSR --KLNRRLSH--------------------------------------------------
BRAF_Mmus_RAF --KIHRSASE--------------------------------------------------
ARAF_Mmus_RAF --KIERSASE--------------------------------------------------
lin-45_Cele_RAF --KLTRSQSA--------------------------------------------------
ksr-2_Cele_RAF --------SN--------------------------------------------------
ksr-1_Cele_KSR --RVNRSPSF--------------------------------------------------
BRAF_Hsap_RAF --KIHRSASE--------------------------------------------------
ARAF_Hsap_RAF --KIERSASE--------------------------------------------------
RAF1_Mmus_RAF --KINRSASE--------------------------------------------------
KSR1_Spur_KSR --GLHRSPSH--------------------------------------------------
Raf_Spur_RAF --KIHRSASE--------------------------------------------------
KSR2_Spur_KSR --NMKHSLSE--------------------------------------------------
AqueK675_Aque_KSR --TRFSSTSL--------------------------------------------------
AqueK676_Aque_KSR --PITRSPSH--------------------------------------------------
AqueK677_Aque_RAF --KIKRSNSE--------------------------------------------------
AqueK678_Aque_RAF --KIKRSNSE--------------------------------------------------
AqueK679_Aque_RAF KDQLNRKESEVIEKEKQLMEKEEQLRRKEEAIVAQQVSSDERYSICVSELEQLRAELDHL
*
RAF1_Hsap_RAF -------------------------------PS---------------------------
KSR2_Hsap_KSR -------------------------------PG---------------------------
KSR1_Hsap_KSR -------------------------------PG---------------------------
phl_Dmel_RAF -------------------------------PN---------------------------
ksr_Dmel_KSR -------------------------------PV---------------------------
KSR2_Mmus_KSR -------------------------------PG---------------------------
KSR1_Mmus_KSR -------------------------------PG---------------------------
BRAF_Mmus_RAF -------------------------------PS---------------------------
ARAF_Mmus_RAF -------------------------------PS---------------------------
lin-45_Cele_RAF -------------------------------PN---------------------------
ksr-2_Cele_RAF -------------------------------KQ---------------------------
ksr-1_Cele_KSR -------------------------------PV---------------------------
BRAF_Hsap_RAF -------------------------------PS---------------------------
ARAF_Hsap_RAF -------------------------------PS---------------------------
RAF1_Mmus_RAF -------------------------------PS---------------------------
KSR1_Spur_KSR -------------------------------PL---------------------------
Raf_Spur_RAF -------------------------------PS---------------------------
KSR2_Spur_KSR -------------------------------PD---------------------------
AqueK675_Aque_KSR -------------------------------PL---------------------------
AqueK676_Aque_KSR -------------------------------PI---------------------------
AqueK677_Aque_RAF -------------------------------PT---------------------------
AqueK678_Aque_RAF -------------------------------PN---------------------------
AqueK679_Aque_RAF QAEQAAKTPDSPFSLEPPFLSQPVPFEDNKQPRIPKKPKQLDLKWQTRKQSPVAFQPQSS
RAF1_Hsap_RAF ----------------------LHRAAH-T------------------------------
KSR2_Hsap_KSR ---------------------HFWKSA---------------------------------
KSR1_Hsap_KSR ---------------------HFWKSA-DI------------------------------
phl_Dmel_RAF ----------------------LTQSQLQN------------------------------
ksr_Dmel_KSR ---------------------NLSRSA---------------------------------
KSR2_Mmus_KSR ---------------------HFWKS----------------------------------
KSR1_Mmus_KSR ---------------------HFWKSA-DI------------------------------
BRAF_Mmus_RAF ----------------------LNRAGFQT------------------------------
ARAF_Mmus_RAF ----------------------LHRTQA--------------------------------
lin-45_Cele_RAF ---------------------VLHLDSQ-Y------------------------------
ksr-2_Cele_RAF ---------------------KRRSTA---------------------------------
ksr-1_Cele_KSR ---------------------MM-KSY---------------------------------
BRAF_Hsap_RAF ----------------------LNRAGFQT------------------------------
ARAF_Hsap_RAF ----------------------LHRTQA--------------------------------
RAF1_Mmus_RAF ----------------------LHRAAH-T------------------------------
KSR1_Spur_KSR ---------------------HLSRSA---------------------------------
Raf_Spur_RAF ---------------------SLNRARLHS------------------------------
KSR2_Spur_KSR ---------------------NLNRLGT--------------------------------
AqueK675_Aque_KSR ---------------------SS-QHC---------------------------------
AqueK676_Aque_KSR ---------------------NLSKSVD--------------------------------
AqueK677_Aque_RAF ---------------------TLCYAGLSY------------------------------
AqueK678_Aque_RAF ---------------------LI-KQNIQN------------------------------
AqueK679_Aque_RAF MAVACMDKIYITYCNYSRSEGKIYEYSLSTDTWTQLPLLRKSEFSLAVVNNDYIVAVGGS
RAF1_Hsap_RAF --------------------EDIN------------------------------------
KSR2_Hsap_KSR ------------------------------------------------------------
KSR1_Hsap_KSR -----------------------N------------------------------------
phl_Dmel_RAF --------------------DEF-------------------------------------
ksr_Dmel_KSR ------------------------------------------------------------
KSR2_Mmus_KSR ------------------------------------------------------------
KSR1_Mmus_KSR -----------------------N------------------------------------
BRAF_Mmus_RAF --------------------EDFS------------------------------------
ARAF_Mmus_RAF --------------------DELP------------------------------------
lin-45_Cele_RAF --------------------SVMDAVMRSQMLSWS-------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF --------------------EDFS------------------------------------
ARAF_Hsap_RAF --------------------DELP------------------------------------
RAF1_Mmus_RAF --------------------EDIN------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF --------------------DDFM------------------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------------------------------------------
AqueK677_Aque_RAF --------------------QEE-------------------------------------
AqueK678_Aque_RAF --------------------QKY-------------------------------------
AqueK679_Aque_RAF AALRKSGSILKYLSASSKWVKEFP-DMPTPRSFPSCVTVGNYLVVAGGEVNSEPVPVVEI
RAF1_Hsap_RAF ------------------------------------------------------------
KSR2_Hsap_KSR ------------------------------------------------------------
KSR1_Hsap_KSR ------------------------------------------------------------
phl_Dmel_RAF ------------------------------------------------------------
ksr_Dmel_KSR ------------------------------------------------------------
KSR2_Mmus_KSR ------------------------------------------------------------
KSR1_Mmus_KSR ------------------------------------------------------------
BRAF_Mmus_RAF ------------------------------------------------------------
ARAF_Mmus_RAF ------------------------------------------------------------
lin-45_Cele_RAF ------------------------------------------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF ------------------------------------------------------------
ARAF_Hsap_RAF ------------------------------------------------------------
RAF1_Mmus_RAF ------------------------------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF ------------------------------------------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------------------------------------------
AqueK677_Aque_RAF ------------------------------------------------------------
AqueK678_Aque_RAF ------------------------------------------------------------
AqueK679_Aque_RAF LDVTKMTWHFVLPFPTRNISRMTVSTDGTFAYFLGGFEEGSLSKLAYAVNVSRLIAETER
RAF1_Hsap_RAF ------------------ACTLTT------------------------------------
KSR2_Hsap_KSR ------------------------------------------------------------
KSR1_Hsap_KSR ------------------S--SKVVPRFE-RF----------------------------
phl_Dmel_RAF -----------------LYLPSPKTPVNF-NN----------------------------
ksr_Dmel_KSR ------------------------------------------------------------
KSR2_Mmus_KSR ------------------------------------------------------------
KSR1_Mmus_KSR ------------------S--SKVMPRFE-RF----------------------------
BRAF_Mmus_RAF ----------------LYACASPKTPIQA-G-----------------------------
ARAF_Mmus_RAF ------------------ACLLS-------------------------------------
lin-45_Cele_RAF ----------------YIPPATAKTPQSA-AA----------------------------
ksr-2_Cele_RAF ------------------------------------------------------------
ksr-1_Cele_KSR ------------------------------------------------------------
BRAF_Hsap_RAF ----------------LYACASPKTPIQA-G-----------------------------
ARAF_Hsap_RAF ------------------ACLLS-------------------------------------
RAF1_Mmus_RAF ------------------ACTLTT------------------------------------
KSR1_Spur_KSR ------------------------------------------------------------
Raf_Spur_RAF ------------------YCPSPKTPIQS-QF----------------------------
KSR2_Spur_KSR ------------------------------------------------------------
AqueK675_Aque_KSR ------------------------------------------------------------
AqueK676_Aque_KSR ------------------------------------------------------------
AqueK677_Aque_RAF ----------------L--NKSPHTPSHN-SS----------------------------
AqueK678_Aque_RAF ----------------L-PMPSYSTPV---------------------------------
AqueK679_Aque_RAF REGKKLWLELSSLPVSGATCASIRNRILALGGYDTMNKSSSDLIYEFDQIEGSWKPTGHL
RAF1_Hsap_RAF ------------------------------------SPRLPVF
KSR2_Hsap_KSR -----------------------------------------EL
KSR1_Hsap_KSR ---------------------------GLG---V-LESSNPKM
phl_Dmel_RAF ---------------------------F-Q-----FFGSAGNI
ksr_Dmel_KSR ---------------------------------------ESVF
KSR2_Mmus_KSR -----------------------------------------AE
KSR1_Mmus_KSR ---------------------------GLG---T-LESGNPKM
BRAF_Mmus_RAF -----------------------------------GYGGFPVH
ARAF_Mmus_RAF ------------------------------------A-ARLVP
lin-45_Cele_RAF ---------------------------AAAANKKAYYNVYGLI
ksr-2_Cele_RAF -------------------------------------HENPLF
ksr-1_Cele_KSR ---------------------------------------ESTF
BRAF_Hsap_RAF -----------------------------------GYGAFPVH
ARAF_Hsap_RAF ------------------------------------A-ARLVP
RAF1_Mmus_RAF ------------------------------------SPRLPVF
KSR1_Spur_KSR ---------------------------------------ESVL
Raf_Spur_RAF ---------------------------A-------VFPFDMRG
KSR2_Spur_KSR ---------------------------------------GLFR
AqueK675_Aque_KSR ---------------------------------------TLRQ
AqueK676_Aque_KSR --------------------------------------NLLHI
AqueK677_Aque_RAF ---------------------------ATG---AESAFHLVKQ
AqueK678_Aque_RAF ------------------------------------SFLNFSF
AqueK679_Aque_RAF PRPFTRGLVAVATYESRKLLVVIGGNMTNN---ISTATNIAYL