ARAF_Hsap -----------VQLLKRIGTGSFGTVFRGRWHGDVA-VKVLKV------SQPTAE--QAQ
RAF1_Hsap -----------VMLSTRIGSGSFGTVYKGKWHGDVA-VKILKV------VDPTPE--QFQ
BRAF_Hsap -----------ITVGQRIGSGSFGTVYKGKWHGDVA-VKMLNV------TAPTPQ--QLQ
ksr-2_Cele TWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAA-VRFVNM------NYLSQEDRRAD
lin-45_Cele -----------FIIQYKVGSGSFGTVYRGEFFGTVA-IKKLNV------VDPTPS--QMA
Raf_Spur -----------IRLGSRIGAGSFGTVFSGQWHGSVA-VKRLNV------KDPTPS--QLQ
ARAF_Mmus -----------VQLLKRIGTGSFGTVFRGRWHGDVA-VKVLKV------AQPTAE--QAQ
BRAF_Mmus -----------ITVGQRIGSGSFGTVYKGKWHGDVA-VKMLNV------TAPTPQ--QLQ
RAF1_Mmus -----------VMLSTRIGSGSFGTVYKGKWHGDVA-VKILKV------VDPTPE--QLQ
phl_Dmel -----------ILIGPRIGSGSFGTVYRAHWHGPVA-VKTLNV------KTPSPA--QLQ
AqueK677_Aque -----------IEVGERIGSGSFGTVYKGKWHGPVA-VKKLNV------SNPTEQ--QMQ
AqueK678_Aque -----------IEVGERIGSGSFGTVYKGKWHGPVA-VKKLNV------SNPTEQ--QMQ
AqueK679_Aque -----------TILKETLGNGAYGVVYKAKCDELICAAKYMHPIFFALSEDPAVNVVATD
: :* * :* *: . . : :: :
ARAF_Hsap AFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLYHHLHVA-DTR--
RAF1_Hsap AFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLYKHLHVQ-ETK--
BRAF_Hsap AFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLYHHLHII-ETK--
ksr-2_Cele VFATEIVSAykNSRHDHIALFYGYVSDPVTNTYAIVTNFYQ--HNTLYHRIHEQLSED--
lin-45_Cele AFKNEV-AVLKKTRHLNVLLFMGWVREP---EIAIITQWCE--GSSLYRHIHVQ-EPRVE
Raf_Spur AFKNEV-AVLRKTRHANILLFMGCTSKP---QLAIVTQWCE--GSSLYKHLHVL-DTK--
ARAF_Mmus AFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLYHHLHVA-DTR--
BRAF_Mmus AFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLYHHLHII-ETK--
RAF1_Mmus AFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLYKHLHVQ-ETK--
phl_Dmel AFKNEV-AMLKKTRHCNILLFMGCVSKP---SLAIVTQWCE--GSSLYKHVHVS-ETK--
AqueK677_Aque AFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLFSHIHVL-EDR--
AqueK678_Aque AFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLFSHIHVL-EDR--
AqueK679_Aque KFKKEC-QLLSRLKHPNIVQYLGTHEVN---GIDTVVLLMELMDSSLHAYLHAHVDSP--
* .* . :* :: : * :. : .:*. :* .
ARAF_Hsap FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGDFGLATVKTRWS-
RAF1_Hsap FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRWS-
BRAF_Hsap FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGDFGLATVKSRWS-
ksr-2_Cele FDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPN-RVVVTDFALMKLERLENP
lin-45_Cele FEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTV
Raf_Spur LVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDL-TVKIGDFGLATVKSRWS-
ARAF_Mmus FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGDFGLATVKTRWS-
BRAF_Mmus FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGDFGLATVKSRWS-
RAF1_Mmus FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRWS-
phl_Dmel FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDL-SVKIGDFGLATAKTRWS-
AqueK677_Aque FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGDFGLATVKTRWD-
AqueK678_Aque FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGDFGLATVKTRWD-
AqueK679_Aque LPFHQEINISLDVARALDYLHVNNIHHRDLSAKNILMLGDY-RAKVSDFGQSKLRNPNG-
: ::: : . .:.*** :.* ***: ::**:: . : **. . .
ARAF_Hsap -GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYAYGVVLYELMTGS
RAF1_Hsap -GSQQVEQPTGSVLWMAPEV-----------IRMQDNNPFSFQSDVYSYGIVLYELMTGE
BRAF_Hsap -GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYAFGIVLYELMTGQ
ksr-2_Cele RRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRR
lin-45_Cele NGGQQQQQPTGSILWMAPEV-----------IRMQDDNPYTPQSDVYSFGICMYEILSSH
Raf_Spur -GSQQFEQPSGSILWMAPEV-----------IRMRDTNPYSFQSDVYAFGVVLFELVTQS
ARAF_Mmus -GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYAYGVVLYELMTGS
BRAF_Mmus -GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYAFGIVLYELMTGQ
RAF1_Mmus -GSQQVEQPTGSVLWMAPEV-----------IRMQDDNPFSFQSDVYSYGIVLYELMAGE
phl_Dmel -GEKQANQPTGSILWMAPEV-----------IRMQELNPYSFQSDVYAFGIVMYELLAEC
AqueK677_Aque -GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYSFGVVVYELISGQ
AqueK678_Aque -GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYSFGVVVYELISGQ
AqueK679_Aque -GFSSNSPCPGNILYMPPET-----------LKVP--PDFAPTLDEFSFGIVTIQIMSRK
: ::..* : . :: * :::* :::
ARAF_Hsap LPYSHIGCRDQIIF--MVGRGYLSPDLSKISSNC-----PKAMRRLLSDCLKFQREERPL
RAF1_Hsap LPYSHINNRDQIIF--MVGRGYASPDLSKLYKNC-----PKAMKRLVADCVKKVKEERPL
BRAF_Hsap LPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPL
ksr-2_Cele MPTG-CDSWDQKLYAKMCGQKAALQRLDAQLQKI-----DGKLHELLLECWSSQPEKRPS
lin-45_Cele LPYSNINNRDQILF--MVGRGYLRPDRSKIRHDT-----PKSMLKLYDNCIMFDRNERPV
Raf_Spur LPYQNIKHKDQIIW--MVGRGYLQPDLSKVRNDT-----PKALKRLITDCYALNRDERPL
ARAF_Mmus LPYSHIGSRDQIIF--MVGRGYLSPDLSKIFSNC-----PKAMRRLLTDCLKFQREERPL
BRAF_Mmus LPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPL
RAF1_Mmus LPYAHINNRDQIIF--MVGRGYASPDLSRLYKNC-----PKAMKRLVADCVKKVKEERPL
phl_Dmel LPYGHISNKDQILF--MVGRGLLRPDMSQVRSDA-----PQALKRLAEDCIKYTPKDRPL
AqueK677_Aque LPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPL
AqueK678_Aque LPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPL
AqueK679_Aque DPKPSDLHRTG--S--LIGTLVEVPEIERRRDDIDSCDPSNPILGLSISCISNDPQERPP
* : * . . : * .* ..**
ARAF_Hsap FPQILAT-------I
RAF1_Hsap FPQILSSI-----EL
BRAF_Hsap FPQILASI-----EL
ksr-2_Cele FQQIVKRITVQMPRK
lin-45_Cele FGEVLER-------L
Raf_Spur FPVVLAA-------L
ARAF_Mmus FPQILAT-------I
BRAF_Mmus FPQILASI-----EL
RAF1_Mmus FPQILSSI-----EL
phl_Dmel FRPLL--------NM
AqueK677_Aque FHQILADL-----ES
AqueK678_Aque FHQVYNNLE----SL
AqueK679_Aque IERMCQLLS----LL
: :