ARAF_Hsap MEP-PRGPPA--------------------------------------------------
RAF1_Hsap MEH-IQGAWKTIS-----------------------------------------------
BRAF_Hsap MAA-LSGGGGG-------------------GAEPGQALFNGDMEPEAGAGAGAAASSAAD
ksr-2_Cele MSD-EKKKKRGFF--------------------------R--------------YSVLTT
lin-45_Cele MSR-INFKKSSAS------------------------------------------TTPTS
Raf_Spur MGD-RT------------------------------------------------------
ARAF_Mmus MEP-PRGPPV--------------------------------------------------
BRAF_Mmus MAA-LSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAG--AGAAASSAAD
RAF1_Mmus MEH-IQGAWKTIS-----------------------------------------------
phl_Dmel MSS-ESSTEGD--------------------------------------------SDLYD
AqueK677_Aque MES-AQF-----------------------------------------------------
AqueK678_Aque DYFIPSA-----------------------------------------------------
AqueK679_Aque MAT-DSATE---------------------------------------------------
ARAF_Hsap ------------------------------------------------------------
RAF1_Hsap ------------------------------------------------------------
BRAF_Hsap PAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLL
ksr-2_Cele SS-------------------------FSSWRRSST--SG----------SISQSSR---
lin-45_Cele PHC-------------------------------PSPRLISLP-----------------
Raf_Spur --KTEQLNVIHMHMELKKKNIEELMERFGTEQPPPPIFLEEYQDLTDQLSELQVEEQRIN
ARAF_Mmus ------------------------------------------------------------
BRAF_Mmus PAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLL
RAF1_Mmus ------------------------------------------------------------
phl_Dmel P-LAEELHNVQLVKHVTRENIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKEQELM
AqueK677_Aque ----LEVQAIRQVIRSTRTTLDEFQRSFPYGQR-TSLVVEEESELKKRLEDLMRREKELS
AqueK678_Aque ----STLHATEIANHITEINLEKSETKYINIRESPSMAAGAVEVVTNQVEEREAAK-ECV
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ------------------------------------------------------------
RAF1_Hsap ----NGFGF-----------KDAVFDGSSCISPTIV------QQFGY-QRRA--------
BRAF_Hsap ESLGNGTDFSV---SSSA-SMDTVTSSSSSSLSVLP------SSLSV-FQNP--------
ksr-2_Cele TTSKTTTSSSV---TSSN-PINAPPPTATSSSSVLP------S-----------------
lin-45_Cele --------RCA---SSSIDRKDQASPMASPSTPLYPKHSDSLHSLSG-HHSA--------
Raf_Spur NEMSNGH--------TSP-NLQTTPPPEPADLHVPYHNK---QSLAP-PHKR--------
ARAF_Mmus ------------------------------------------------------------
BRAF_Mmus ESLGNGADFSV---SSSA-SMDTVTSSSSSSLSVLP------SSLSV-FQTP--------
RAF1_Mmus ----NGFGL-----------KDAVFDGSSCISPTIV------QQFGY-QRRA--------
phl_Dmel ERLNSQDQQED---SSLV-ERFKEQPHYQNQTQIL-QQQ---RQLARVHHGNDL------
AqueK677_Aque GQG---WDSSD-----SA-EQELVSSSSPDGSDQSP------RGPLS-PRNP-LTVSHSY
AqueK678_Aque ESLVSQHRKEDCQQKECL-KIDEYGISSIS------------------------------
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ------------------------------NGAEPSRAVGTVKVYLPNKQRTVVTVRDGM
RAF1_Hsap ------------------S-D-------DGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGM
BRAF_Hsap ------------------T-D-------VARSNPKSPQKPIVRVFLPNKQRTVVPARCGV
ksr-2_Cele -----------------------------TSSEPPPPA----------------------
lin-45_Cele ------------------G-G-AG----TSDKEPPKFKYKMIMVHLPFDQHSRVEVRPGE
Raf_Spur ------------------E-F-------TNQQHPKSPLSQSVRAFLPNQQRTSVLAKSGT
ARAF_Mmus ------------------------------SGAEPSRAVGTVKVYLPNKQRTVVTVREGM
BRAF_Mmus ------------------T-D-------ASRNNPKSPQKPIVRVFLPNKQRTVVPARCGV
RAF1_Mmus ------------------S-D-------DGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGM
phl_Dmel ------------------T-DSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGV
AqueK677_Aque PLSPVRHLPPLPPVTVSIEND--T----VAPSSPVTTHAALIRAHLPEGQRTIVPIRQGV
AqueK678_Aque -----------------------------KCTTLLREKQVLIRAHLPEGQRTIVPIRQGV
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap SVYDSLDKALKVRGLNQDCCVVYRLI---KGRKT----VTAWDTAIAPLDGEELIV--EV
RAF1_Hsap SLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKA----RLDWNTDAASLIGEELQV--DF
BRAF_Hsap TVRDSLKKALMMRGLIPECCAVYRIQ---DGEKK----PIGWDTDISWLTGEELHV--EV
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele TARDAISKLLKKRNITPQLCHVNASS---DPKQESIELSLTMEEIASRLPGNELWVHSEY
Raf_Spur TLKYCLSKAMKMRELTPEMCIVYRV-----NPRM----ALSWDTDMMYLAGEEISV--EL
ARAF_Mmus SVYDSLDKALKVRGLNQDCCVVYRLI---KGRKT----VTAWDTAIAPLDGEELIV--EV
BRAF_Mmus TVRDSLKKALMMRGLIPECCAVYRIQ---DGEKK----PIGWDTDISWLTGEELHV--EV
RAF1_Mmus SLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKA----RLDWNTDAASLIGEELQV--DF
phl_Dmel RLCDALMKALKLRQLTPDMCEVSTTH---SG-RH----IIPWHTDIGTLHVEEIFV--RL
AqueK677_Aque TIQDALMKAMKTRNLTPNTCIVYA-----ESPRL----LIEWDTDTTQLSGKEVFV--EY
AqueK678_Aque TIQDALMKAMKTRNLTPNTCIVYA-----ESPRL----LIEWDTDTTQLSGKEVFV--VV
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap L-EDVPL---TMHNFV-RKTFFSLAFCDFCLKF----------LFHGFRCQTCGYKFHQH
RAF1_Hsap L-DHVPL---TTHNFA-RKTFLKLAFCDICQKF----------LLNGFRCQTCGYKFHEH
BRAF_Hsap L-ENVPL---TTHNFV-RKTFFTLAFCDFCRKL----------LFQGFRCQTCGYKFHQR
ksr-2_Cele ---SAPPRISIYHKMVPSKS--KFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKG
lin-45_Cele L-NTVSS---IKHAIV-RRTFIPPKSCDVCNNPI---------WMMGFRCEFCQFKFHQR
Raf_Spur KAQNFPAPSSISHNFV-RKTFFAIAFCDSCQKL----------LFHGFRCQTCSYKFHQR
ARAF_Mmus L-EDVPL---TMHNFV-RKTFFSLAFCDFCLKF----------LFHGFRCQTCGYKFHQH
BRAF_Mmus L-ENVPL---TTHNFV-RKTFFTLAFCDFCRKL----------LFQGFRCQTCGYKFHQR
RAF1_Mmus L-DHVPL---TTHNFA-RKTFLKLAFCDICQKF----------LLNGFRCQTCGYKFHEH
phl_Dmel L-DKFPIRTHIKHQII-RKTFFSLVFCEGCRRL----------LFTGFYCSQCNFRFHQR
AqueK677_Aque Q-KSPKLASTNHHNFV-RKTFIALAFCDVCKKL----------LFQGFRCETCGFRYHQR
AqueK678_Aque F-MAYPFLSLFHHFFV-RKTFIALAFCDVCKKL----------LFQGFRCETCGFRYHQR
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap CSSKVPTVCVDMSTNR--QQFY-HSV-----QDL--------------SGGSRQHE-APS
RAF1_Hsap CSTKVPTMCVDWSNIR--QLLL-FPN-----STI---------------GDSGVPA-LPS
BRAF_Hsap CSTEVPLMCVNYDQLD--LLFV-SKF--FEHHPIPQEEA---SLAETALTSGSSPS-APA
ksr-2_Cele CLDRVKNDCKITTQYM--GGIL-E------NAVIQ--------------SNKKQWE-KPT
lin-45_Cele CSSFAPLYCDLLQSVPKNEDLVKELFGIASQVEGPDRSVAEIVLANLAPTSGQSPAATPD
Raf_Spur CANKVPTICISTTGDN---LYK-LLL--ALRKE--DDYN---DYPDT---FPDEPE-SPS
ARAF_Mmus CSSKVPTVCVDMSTNR--RQFY-HSI-----QDL--------------SGGSRQQE-APS
BRAF_Mmus CSTEVPLMCVNYDQLD--LLFV-SKF--FEHHPVPQEEA---SFPETALPSGSS-S-APP
RAF1_Mmus CSTKVPTMCVDWSNIR--QLLL-FPN-----STV---------------GDSGVPA-PPS
phl_Dmel CANRVPMLCQPFPMDS---YYQ-LLL--AENPDN---GV---GFPG-------RGT-AVR
AqueK677_Aque CSPRVPIQCGGVDDDL---IMA-YIL--SQHPPKPDD--------------SPQPS-SPV
AqueK678_Aque CSPRVPIQCGGVDDDL---IMA-YIL--SQHPPKPDD--------------SPQPS-SPV
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap N--RPLNELLTPQG-PSPRTQHCDPEHFP----FPA--P---ANAPLQRIRSTSTPNVHM
RAF1_Hsap LTMRRMRESVSRMP-VSSQHRYSTPHAFTFNTSSPS--S---EGSLSQRQRSTSTPNVHM
BRAF_Hsap S--DSI----GPQILTSPSPSKSIPIPQPFRPADED--H---RNQFGQRDRSSSAPNVHI
ksr-2_Cele T--ASISKSLTTSP-TCSTSTTMSPAGVESMLEK-----WNKTKFLKNRENICKIENVHK
lin-45_Cele S--S------HPDLTSIKRTGGVKRHPMAVSPQNET--SQLSPSGPYPRDRSSSAPNINA
Raf_Spur -------------------SD------------DQD--F---PRNTLPRERSTSAPNICQ
ARAF_Mmus N--LSVNELLTPQG-PSPFTQQRDQEHFS----FPA--P---ANPPLQRIRSTSTPNVHM
BRAF_Mmus S--DST----GPQILTSPSPSKSIPIPQPFRPADED--H---RNQFGQRDRSSSAPNVHI
RAF1_Mmus FPMRRMRESVSRMP-ASSQHRYSTPHAFTFNTSSPS--S---EGSLSQRQRSTSTPNVHM
phl_Dmel FNMSSRSRSR-RCS-SSGSSSSSKPPSSSSGNHRQG--R---PPRISQDDRSNSAPNVCI
AqueK677_Aque -----------PH---SP----TVPLLVPTKGGDEGETH-SRFLNTSSRERSISTPNVLY
AqueK678_Aque -----------PH---SP----TVPLLVPTKGGDEGETH-SRFLNTSSRERSISTPNVLY
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap VSTTAPM----DSNLIQLTGQS--FS----------------------------------
RAF1_Hsap VSTTLPV----DSRMIEDAIRS--HS----------------------------------
BRAF_Hsap NT-IEPVN--IDDL--------------IRDQ-----------------GFRGDGAPLNQ
ksr-2_Cele TRKLISM----TTSTLDDVT----------------------------------------
lin-45_Cele INDEATVQH--NQRIL-DALEAQRLEEESRDKTGSLLSTQARHRPHFQSGHILSGARMNR
Raf_Spur NAVNVPG----Q--QFDSE--A--FSRFAFPV----------KSSLNPNGHTASA-AV--
ARAF_Mmus VSTTAPM----DSSLMQFTAQS--FS----------------------------------
BRAF_Mmus NT-IEPVN--IDEKFPEVELQD--QRDLIRDQ-----------------GFRGDGAPLNQ
RAF1_Mmus VSTTLHV----DSRMIEDAIRS--HS----------------------------------
phl_Dmel NN-IRSVTSEVQRSLIMQ------------------------------------------
AqueK677_Aque NS---PAN--YDPYPTT--TED--NREFLGPM-----------------PFSSV------
AqueK678_Aque NS---PAN--YDPYPTT--TED--NREFLGPM-----------------PFSSV------
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ----------TD-A---AGS----------------------------------------
RAF1_Hsap ----------ES-A---SPS----------------------------------------
BRAF_Hsap LMRCL--RKYQS-R---TPSPLLHSVPSEIVFDFEPGPVF--------------------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele LHPLVDCTPLGS-N---SPSSTCSSPPGGLIGQ---------------------------
Raf_Spur -------NIHGAHGGGHGKVLTPNSAVQDGVFDYDPTNIANDGHTASAAVNIHGAHG---
ARAF_Mmus ----------TD-A---AG-----------------------------------------
BRAF_Mmus LMRCL--RKYQS-R---TPSPLLHSVPSEIVFDFEPGPVF--------------------
RAF1_Mmus ----------ES-A---SPS----------------------------------------
phl_Dmel ------------------------------------------------------------
AqueK677_Aque ---------SGS-Y---VDNHLSHSTEYNSVFDYNVSSSGNSSRDAPIAHPPHSRRGLCG
AqueK678_Aque ---------SGS-Y---VDNHLSHSTEYNSVFDYNVSSSGNSSRDAPIAHPPHSRRGLCG
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ------------------------------------------------------RG----
RAF1_Hsap ------------------------------------------------------------
BRAF_Hsap ------------------------------------------------------RGSTT-
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele ------------------------------------------------------------
Raf_Spur -------------------------GGHGKVLTPNSAVQD----GVFDYDPTNIANGLAS
ARAF_Mmus ------------------------------------------------------RG----
BRAF_Mmus ------------------------------------------------------RGSTT-
RAF1_Mmus ------------------------------------------------------------
phl_Dmel ------------------------------------------------------------
AqueK677_Aque RGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKER------RNSTE-
AqueK678_Aque RGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKER------RNSTE-
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap G-----------------------SDGTPRGSPSPASVS---------------------
RAF1_Hsap A-----------------------------LSSSPNNLSP--------------------
BRAF_Hsap G-----------------------LSATPPA-SLPGSLT---------------------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele ----------------------------PTLGQSPN-VSGST----TSSLVAAHLHTLPL
Raf_Spur S-----------------------LPNTRNLIHSPKRESG--------------------
ARAF_Mmus ------------------------GDGAPRGSPSPASVS---------------------
BRAF_Mmus G-----------------------LSATPPA-SLPGSLT---------------------
RAF1_Mmus A-----------------------------LSSSPNNLSP--------------------
phl_Dmel --------------------------ARPPL-PHPCTDH---------------------
AqueK677_Aque GRSPMERRLHSSSERHRHRSLERRSSSGDRTSATPDSMSP-SYSTGQS---------PLQ
AqueK678_Aque GRSPMERRLHSSSERHRHRSLERRSSSGDRTSATPDSMSP-SYSTGQS---------PLQ
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ------------------------SGRKSPHSKSPAEQ-RERK----SLADDKKKVKN--
RAF1_Hsap ------------------------TGWSQPKTPVPA-Q-RERAPV--SGTQEKNKIRP--
BRAF_Hsap ------------------------NVKALQKS--PGPQ-RERKSS--SSSEDRNRMKT--
ksr-2_Cele --------------------------------------------T--FNSEINEEMDE--
lin-45_Cele TPPQ----------------------SAPPQKISPGFF-RNRSRS--PGERLDAQRPR--
Raf_Spur -------------------------SHSSQPS--PTHQPRWKDVLPGS-DSKDNKIKPPT
ARAF_Mmus ------------------------SGRKSPHSKLPSEQ-RERK----SLADEKKKVKN--
BRAF_Mmus ------------------------NVKALQKS--PGPQ-RERKSSSSSSSEDRSRMKT--
RAF1_Mmus ------------------------TGWSQPKTPVPA-Q-RERAPG--SGTQEKNKIRP--
phl_Dmel ----------------------SNSTQASPTSTLKH-N-RPRARS---ADESNKNLLL--
AqueK677_Aque TPTGSKPPLQTSLSSGDSGLGGSRSSTSYSSSTLPS-Q-RRRQRT---SSEDKRA--K--
AqueK678_Aque TPTGSKPPLQTSLSSGDSGLGGSRSSTSYSSSTLPS-Q-RRRQRT---SSEDKRALQK--
AqueK679_Aque ------------------------------------------------------------
ARAF_Hsap ------LGYRDSGYYWEVPPSEVQ-LLKRIGTGSFGTVFRGRWHGDVAV-KVLKV-----
RAF1_Hsap ------RGQRDSSYYWEIEASEVM-LSTRIGSGSFGTVYKGKWHGDVAV-KILKV-----
BRAF_Hsap ------LGRRDSSDDWEIPDGQIT-VGQRIGSGSFGTVYKGKWHGDVAV-KMLNV-----
ksr-2_Cele ------ETVLMTWEDVTIKLTDVD-VMTKIGDGRFGSVYFGGYHGNAAV-RFVNM-----
lin-45_Cele ------PPQKPHHEDWEILPNEFI-IQYKVGSGSFGTVYRGEFFGTVAI-KKLNV-----
Raf_Spur TLLGHRRTRRDSNDDWEIPTEEIR-LGSRIGAGSFGTVFSGQWHGSVAV-KRLNV-----
ARAF_Mmus ------LGYRDSGYYWEVPPSEVQ-LLKRIGTGSFGTVFRGRWHGDVAV-KVLKV-----
BRAF_Mmus ------LGRRDSSDDWEIPDGQIT-VGQRIGSGSFGTVYKGKWHGDVAV-KMLNV-----
RAF1_Mmus ------RGQRDSSYYWEIEASEVM-LSTRIGSGSFGTVYKGKWHGDVAV-KILKV-----
phl_Dmel ------RDAKSSEENWNILAEEIL-IGPRIGSGSFGTVYRAHWHGPVAV-KTLNV-----
AqueK677_Aque ------VKCKDSSDVWEIPYNEIE-VGERIGSGSFGTVYKGKWHGPVAV-KKLNV-----
AqueK678_Aque ------VKCKDSSDVWEIPYNEIE-VGERIGSGSFGTVYKGKWHGPVAV-KKLNV-----
AqueK679_Aque --------------DGEFKFRQVTILKETLGNGAYGVVYKAKCDELICAAKYMHPIFFAL
. :. : :* * :* *: . . : ::
ARAF_Hsap -SQPTAE--QAQAFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLY
RAF1_Hsap -VDPTPE--QFQAFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLY
BRAF_Hsap -TAPTPQ--QLQAFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLY
ksr-2_Cele -NYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQ--HNTLY
lin-45_Cele -VDPTPS--QMAAFKNEV-AVLKKTRHLNVLLFMGWVREP---EIAIITQWCE--GSSLY
Raf_Spur -KDPTPS--QLQAFKNEV-AVLRKTRHANILLFMGCTSKP---QLAIVTQWCE--GSSLY
ARAF_Mmus -AQPTAE--QAQAFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLY
BRAF_Mmus -TAPTPQ--QLQAFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLY
RAF1_Mmus -VDPTPE--QLQAFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLY
phl_Dmel -KTPSPA--QLQAFKNEV-AMLKKTRHCNILLFMGCVSKP---SLAIVTQWCE--GSSLY
AqueK677_Aque -SNPTEQ--QMQAFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLF
AqueK678_Aque -SNPTEQ--QMQAFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLF
AqueK679_Aque SEDPAVNVVATDKFKKEC-QLLSRLKHPNIVQYLGTHEVN---GIDTVVLLMELMDSSLH
: * .* . :* :: : * :. : .:*.
ARAF_Hsap HHLHVA-DTR--FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGD
RAF1_Hsap KHLHVQ-ETK--FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGD
BRAF_Hsap HHLHII-ETK--FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGD
ksr-2_Cele HRIHEQLSED--FDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPN-RVVVTD
lin-45_Cele RHIHVQ-EPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGD
Raf_Spur KHLHVL-DTK--LVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDL-TVKIGD
ARAF_Mmus HHLHVA-DTR--FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGD
BRAF_Mmus HHLHII-ETK--FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGD
RAF1_Mmus KHLHVQ-ETK--FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGD
phl_Dmel KHVHVS-ETK--FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDL-SVKIGD
AqueK677_Aque SHIHVL-EDR--FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGD
AqueK678_Aque SHIHVL-EDR--FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGD
AqueK679_Aque AYLHAHVDSP--LPFHQEINISLDVARALDYLHVNNIHHRDLSAKNILMLGDY-RAKVSD
:* . : ::: : . .:.*** :.* ***: ::**:: . : *
ARAF_Hsap FGLATVKTRWS--GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYA
RAF1_Hsap FGLATVKSRWS--GSQQVEQPTGSVLWMAPEV-----------IRMQDNNPFSFQSDVYS
BRAF_Hsap FGLATVKSRWS--GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYA
ksr-2_Cele FALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYS
lin-45_Cele FGLATVKTKWTVNGGQQQQQPTGSILWMAPEV-----------IRMQDDNPYTPQSDVYS
Raf_Spur FGLATVKSRWS--GSQQFEQPSGSILWMAPEV-----------IRMRDTNPYSFQSDVYA
ARAF_Mmus FGLATVKTRWS--GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYA
BRAF_Mmus FGLATVKSRWS--GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYA
RAF1_Mmus FGLATVKSRWS--GSQQVEQPTGSVLWMAPEV-----------IRMQDDNPFSFQSDVYS
phl_Dmel FGLATAKTRWS--GEKQANQPTGSILWMAPEV-----------IRMQELNPYSFQSDVYA
AqueK677_Aque FGLATVKTRWD--GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYS
AqueK678_Aque FGLATVKTRWD--GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYS
AqueK679_Aque FGQSKLRNPNG--GFSSNSPCPGNILYMPPET-----------LKVP--PDFAPTLDEFS
*. . . : ::..* : . :: * ::
ARAF_Hsap YGVVLYELMTGSLPYSHIGCRDQIIF--MVGRGYLSPDLSKISSNC-----PKAMRRLLS
RAF1_Hsap YGIVLYELMTGELPYSHINNRDQIIF--MVGRGYASPDLSKLYKNC-----PKAMKRLVA
BRAF_Hsap FGIVLYELMTGQLPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMA
ksr-2_Cele FGTIFFELLLRRMPTG-CDSWDQKLYAKMCGQKAALQRLDAQLQKI-----DGKLHELLL
lin-45_Cele FGICMYEILSSHLPYSNINNRDQILF--MVGRGYLRPDRSKIRHDT-----PKSMLKLYD
Raf_Spur FGVVLFELVTQSLPYQNIKHKDQIIW--MVGRGYLQPDLSKVRNDT-----PKALKRLIT
ARAF_Mmus YGVVLYELMTGSLPYSHIGSRDQIIF--MVGRGYLSPDLSKIFSNC-----PKAMRRLLT
BRAF_Mmus FGIVLYELMTGQLPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMA
RAF1_Mmus YGIVLYELMAGELPYAHINNRDQIIF--MVGRGYASPDLSRLYKNC-----PKAMKRLVA
phl_Dmel FGIVMYELLAECLPYGHISNKDQILF--MVGRGLLRPDMSQVRSDA-----PQALKRLAE
AqueK677_Aque FGVVVYELISGQLPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCI
AqueK678_Aque FGVVVYELISGQLPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCI
AqueK679_Aque FGIVTIQIMSRKDPKPSDLHRTG--SL--IGTLVEVPEIERRRDDIDSCDPSNPILGLSI
:* ::: * * . . : *
ARAF_Hsap DCLKFQREERPLFPQILATIELLQRSLPKIE-----------------------------
RAF1_Hsap DCVKKVKEERPLFPQILSSIELLQHSLPKIN-----------------------------
BRAF_Hsap ECLKKKRDERPLFPQILASIELLARSLPKIH-----------------------------
ksr-2_Cele ECWSSQPEKRPSFQQIVKRITV---QMPR-------------------------------
lin-45_Cele NCIMFDRNERPVFGEVLERLRDI--ILPKLT-----------------------------
Raf_Spur DCYALNRDERPLFPVVLAALESLARQLPKIH-----------------------------
ARAF_Mmus DCLKFQREERPLFPQILATIELLQRSLPKIE-----------------------------
BRAF_Mmus ECLKKKRDERPLFPQILASIELLARSLPKIH-----------------------------
RAF1_Mmus DCVKKVKEERPLFPQILSSIELLQHSLPKIN-----------------------------
phl_Dmel DCIKYTPKDRPLFRPLLNMLENMLRTLPKIH-----------------------------
AqueK677_Aque KCCQFEKDDRPLFHQILADLESLSDSMPKIK-----------------------------
AqueK678_Aque KCCQFEKDDRPLFHQVYNNLESLSDSMPKIK-----------------------------
AqueK679_Aque SCISNDPQERPPIERMCQLLSLLKNT-SQYKKSAMGLSSSSDEGKENVHPFEDYGEVLIV
.* ..** : : : .:
ARAF_Hsap ------------------------------------------------------------
RAF1_Hsap ------------------------------------------------------------
BRAF_Hsap ------------------------------------------------------------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele ------------------------------------------------------------
Raf_Spur ------------------------------------------------------------
ARAF_Mmus ------------------------------------------------------------
BRAF_Mmus ------------------------------------------------------------
RAF1_Mmus ------------------------------------------------------------
phl_Dmel ------------------------------------------------------------
AqueK677_Aque ------------------------------------------------------------
AqueK678_Aque ------------------------------------------------------------
AqueK679_Aque ELNENDTHYSSKIDDLTRTIKDKENLLKDQSNILELRNKQLLQKSNIIDKYKLQLEEKES
ARAF_Hsap -------------------------------RSASE------------------------
RAF1_Hsap -------------------------------RSASE------------------------
BRAF_Hsap -------------------------------RSASE------------------------
ksr-2_Cele --------------------------------KESN------------------------
lin-45_Cele -------------------------------RSQSA------------------------
Raf_Spur -------------------------------RSASE------------------------
ARAF_Mmus -------------------------------RSASE------------------------
BRAF_Mmus -------------------------------RSASE------------------------
RAF1_Mmus -------------------------------RSASE------------------------
phl_Dmel -------------------------------RSASE------------------------
AqueK677_Aque -------------------------------RSNSE------------------------
AqueK678_Aque -------------------------------RSNSE------------------------
AqueK679_Aque EDAEADKKKSQLEIYNLELETKVSELKDQLNRKESEVIEKEKQLMEKEEQLRRKEEAIVA
. *
ARAF_Hsap ---------------------------------------------------------PS-
RAF1_Hsap ---------------------------------------------------------PS-
BRAF_Hsap ---------------------------------------------------------PS-
ksr-2_Cele ---------------------------------------------------------KQ-
lin-45_Cele ---------------------------------------------------------PN-
Raf_Spur ---------------------------------------------------------PS-
ARAF_Mmus ---------------------------------------------------------PS-
BRAF_Mmus ---------------------------------------------------------PS-
RAF1_Mmus ---------------------------------------------------------PS-
phl_Dmel ---------------------------------------------------------PN-
AqueK677_Aque ---------------------------------------------------------PT-
AqueK678_Aque ---------------------------------------------------------PN-
AqueK679_Aque QQVSSDERYSICVSELEQLRAELDHLQAEQAAKTPDSPFSLEPPFLSQPVPFEDNKQPRI
ARAF_Hsap ------------------------------------------------LHRTQ--A----
RAF1_Hsap ------------------------------------------------LHRAA-HT----
BRAF_Hsap ------------------------------------------------LNRAGFQT----
ksr-2_Cele ------------------------------------------------KRRSTAH-----
lin-45_Cele ------------------------------------------------VLHLDSQY----
Raf_Spur -----------------------------------------------SLNRARLHS----
ARAF_Mmus ------------------------------------------------LHRTQ--A----
BRAF_Mmus ------------------------------------------------LNRAGFQT----
RAF1_Mmus ------------------------------------------------LHRAA-HT----
phl_Dmel ------------------------------------------------LTQSQLQN----
AqueK677_Aque -----------------------------------------------TLCYAGLSY----
AqueK678_Aque ------------------------------------------------LIKQNIQN----
AqueK679_Aque PKKPKQLDLKWQTRKQSPVAFQPQSSMAVACMDKIYITYCNYSRSEGKIYEYSLSTDTWT
ARAF_Hsap ----------------------------------------------DEL-----------
RAF1_Hsap ----------------------------------------------EDI-----------
BRAF_Hsap ----------------------------------------------EDF-----------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele ----------------------------------------------SVM---------DA
Raf_Spur ----------------------------------------------DDF-----------
ARAF_Mmus ----------------------------------------------DEL-----------
BRAF_Mmus ----------------------------------------------EDF-----------
RAF1_Mmus ----------------------------------------------EDI-----------
phl_Dmel ----------------------------------------------DEF-----------
AqueK677_Aque ----------------------------------------------QEE-----------
AqueK678_Aque ----------------------------------------------QKY-----------
AqueK679_Aque QLPLLRKSEFSLAVVNNDYIVAVGGSAALRKSGSILKYLSASSKWVKEFPDMPTPRSFPS
ARAF_Hsap ------------------------------------------------------------
RAF1_Hsap ------------------------------------------------------------
BRAF_Hsap ------------------------------------------------------------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele VMRSQ-------------------------------------------------------
Raf_Spur ------------------------------------------------------------
ARAF_Mmus ------------------------------------------------------------
BRAF_Mmus ------------------------------------------------------------
RAF1_Mmus ------------------------------------------------------------
phl_Dmel ------------------------------------------------------------
AqueK677_Aque ------------------------------------------------------------
AqueK678_Aque ------------------------------------------------------------
AqueK679_Aque CVTVGNYLVVAGGEVNSEPVPVVEILDVTKMTWHFVLPFPTRNISRMTVSTDGTFAYFLG
ARAF_Hsap ----------------------------------------P--ACLLSAA----------
RAF1_Hsap ----------------------------------------N--ACTLTTSP---------
BRAF_Hsap ----------------------------------------SLYACASPKTPIQA-GG---
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele -----M-------------------------------LSWSYIPPATAKTPQSA-AA---
Raf_Spur ----------------------------------------M--YCPSPKTPIQS-QF---
ARAF_Mmus ----------------------------------------P--ACLLSAA----------
BRAF_Mmus ----------------------------------------SLYACASPKTPIQA-GG---
RAF1_Mmus ----------------------------------------N--ACTLTTSP---------
phl_Dmel ------------------------------------------LYLPSPKTPVNF-NN---
AqueK677_Aque -----------------------------------------L--NKSPHTPSHN-SS---
AqueK678_Aque -----------------------------------------L-PMPSYSTPVS-------
AqueK679_Aque GFEEGSLSKLAYAVNVSRLIAETERREGKKLWLELSSLPVSGATCASIRNRILALGGYDT
ARAF_Hsap ------------------------------------------------------------
RAF1_Hsap ------------------------------------------------------------
BRAF_Hsap ------------------------------------------------------------
ksr-2_Cele ------------------------------------------------------------
lin-45_Cele ----------------------------------------------------AAAANKKA
Raf_Spur ----------------------------------------------------A-----V-
ARAF_Mmus ------------------------------------------------------------
BRAF_Mmus ------------------------------------------------------------
RAF1_Mmus ------------------------------------------------------------
phl_Dmel ----------------------------------------------------FQ----F-
AqueK677_Aque ----------------------------------------------------ATGA--ES
AqueK678_Aque ------------------------------------------------------------
AqueK679_Aque MNKSSSDLIYEFDQIEGSWKPTGHLPRPFTRGLVAVATYESRKLLVVIGGNMTNNI--ST
ARAF_Hsap ---R-LVP
RAF1_Hsap ---RLPVF
BRAF_Hsap -YGAFPVH
ksr-2_Cele ---ENPLF
lin-45_Cele YYNVYGLI
Raf_Spur -FPFDMRG
ARAF_Mmus ---R-LVP
BRAF_Mmus -YGGFPVH
RAF1_Mmus ---RLPVF
phl_Dmel -FGSAGNI
AqueK677_Aque -AFHLVKQ
AqueK678_Aque --FLNFSF
AqueK679_Aque -ATNIAYL